Abstract: Objective To study clinical characteristics and methods of diagnosis of elderly pulmonary tuberculosis with fungi infection.Methods Seventy-five paitents with elderly pulmonary tuberculosis complicated with fungi infection from 2008 to 2011 in Hospital for Chronic Diseases of Gaozhou were enrolled, including 48 male and 27 female patients, with aged 61-81 years old,and the average age was(71.5±10.5) years old.All patients had a long history of using antibiotic therapy and basis diseases.Results of clinical characteristics,the radiographic manifestations on lung lesions, using antibiotic therapy, fungus culture and drug-resistance were analyzed.ResultsThe common fungal pathogen was Candida albicans 68.0%(51/75),Glabrata 10.7%(8/75), C.tropicalis 6.7%(5/75) and Candida krusei 5.3%(4/75) in elderly patients with elderly pulmonary tuberculosis complicated with fungi infection. The resistant rates were low in Candida albicans. Ten(13.3%,10/75) patients had less than 1 field lesion, 13(17.3%,13/75) patients had 2 lung fields lesion,52(69.3%,52/75) patients had more than 3 lung fields lesion. The patients with pulmonary tuberculosis complicated with fibrosis were easily infected by fungi 78.7%(59/75). The overall clinical cure rate was 88.0%(66/75),the improvement rate was 9.3%(7/75),the death rate was 2.7%(2/75) after treatment.Conclusion The lung lesion areas were quite extensive with destroyed lobes or lung segments. The incidence of fungi infection will be higher with the increasing of lung lesion areas. We should take efforts to reduce the rate of fungi infection and resistance rate, which will be contribute to tuberculosis control and reduce death rate.