Abstract: Objective To analyze the clinical and etiological characteristics of sepsis induced by pneumonia and to evaluate antibiotic susceptibility of the pathogens.Methods A prospective study was conducted on sepsis patients induced by pneumonia in ICU of People’s Hospital of Guizhou Province. The sputum and blood samples were collected for culture and bacteria were isolated and identified using conventional methods and the antimicrobial susceptibility against bacteria by Kirby-Bauer method was tested.Results There were 110 patients with 88 strains of isolated pathogenic bacteria. The most common pathogen was Klebsiella pneumonia (34.1%,30/88),the second and the third were Pseudomonas aeruginosa (28.4%,25/88) and Escherichia coli (15.9%,14/88),respectively. In severe sepsis with pneumonia, Klebsiella pneumonia was the most isolated pathogens and Staphylococcus aureus was the major isolated gram positive coccus pathogen. The resistant rate of isolates from severe sepsis with pneumonia patients were 11.53%(6/52), 11.53%(6/52),9.61%(5/52) to ceftazidime,cefotaxime sodium and ceftriaxone respectively, which were significantly higher than isolates from sepsis(P<0.05).Conclusion Gram negative bacteria plays an important role in severe sepsis induced by pneumonia, and the degree of drug resistance to antibiotics from sepsis are higher than those isolated from severe sepsis.