Abstract: Objective By comparing the clinical features of pulmonary tuberculosis (PTB) and TB pleurisy patients among local and floating population registered from 2008 to 2012 in Panyu Guangzhou to identify the difference between the two groups, and provide the basis for formulation of targeted control measures.Methods We collected the data of 8031 PTB and TB pleurisy patients from all levels TB institutions of Guangzhou, among them 3931 are local patients and 4100 are from floating population. According to the requirement of TB special report of ‘China Disease Control Information System’, patient’s information were checked and validated monthly, excel table were downloaded, and converted into the Foxpro data table. The chi-square test was used for categorical data statistics and t test for measurement data. α=0.05 is used as standard to determine if the difference is statistically significant.Results For local patients, the male to female ratio was 2.27∶1(2730/1201); primarily middle-aged and young, and above 60 years old were also not rare, the median age was 37.41 years old; farmers, others, workers and students patients constituted larger proportion, they occupied 34.09%(1340/3931), 20.96%(824/3931), 19.59%(770/3931), 10.68%(420/3931) respectively; patients were mainly previously untreated (92.50%,3630/3931) and secondary PTB(96.11%,3778/3931), 25.38%(998/3931) of patients had cavity and 49.22%(1935/3931) was smear positive; Most patients are found through referral and passive identification, the treatment delay rate was 52.66%(2070/3931), the average number of days from symptom onset to seeking care was 76.39d, to TB diagnosis confirmation was 105.75d. For patients of floating population, the male to female ratio was 1.92∶1(2696/1404); primarily middle-aged and young, and above 60 years old were rare, the median age was 29.03 years old; workers, others and unemployed patients constituted larger proportion, they occupied 73.46%(3012/4100),17.39%(713/4100)and 4.88%(200/4100) respectively; patients were mainly previously untreated (97.22%,3986/4100) and secondary PTB(93.76%,3844/4100), less patients had cavity (17.05%,699/4100) or smear positive(28.80%, 1181/4100); Most patients are found through referral and physical examination, the treatment delay rate was 48.46%(1987/4100), the average number of days from symptom onset to seeking care was 51.55d, to TB diagnosis confirmation was 63.17d. Comparing the two groups, there was statistically significant difference in sex ratio,average age, the age structure, the occupational structure, sputum smear-positive rate, new and retreatment ratio, constituent of disease type, proportion of patients with cavity, constituent of ways of case detection, proportion of treatment delay, the average number of days from symptom onset to seeking care, proportion of TB diagnosis delay, the average number of days from symptom onset to TB diagnosis confirmation, the statistical values were 12.48, 26.27, 890.52, 1440.73, 352.38, 92.65, 31.13, 83.74, 1422.02, 14.12, 3.27, 13.91, 4.66 respectively(the average age, the average number of days from symptom onset to seeking care, the average number of days from symptom onset to TB diagnosis confirmation using t test, other using χ² test),P<0.05.Conclusion The two groups were significantly different in gender, age, occupation, disease type, new treatment and retreatment ratio, whether infectious, with cavity or not, seeking care delay, days from symptom onset to seeking care, diagnosis delay, days from symptom onset to TB diagnosis confirmation. Local and floating population patients all have their own features, therefore it is necessary to take the different and more focused control measures.