Abstract: Objective To observe the therapeutic effects of the pulmonary tuberculosis patients combined with pulmonary fungal infections.Methods Thirty-five tuberculosis combined with pulmonary fungal infections patients admitted in our hospital from December 2012 to December 2014 were selected and the clinical data were retrospectively analyzed. The SPSS 16.0 software is used for statistical analysis, and the differences of before and after treatment were compared by t-test and χ²-test.Results The total effective rate was 94.29% (33/35).The mainly fungal infection was Candida albicans accounting for 28.57% (10/35). The sputum smear-negative culture-positive rate of patients before and after the treatment was 94.29% (33/35)、2.86 (1/35) respectively (χ²=164.94,P＜0.05). The white blood cell count was reduced from (5.8±1.6)×10⁹/L to (4.7±1.5)×10⁹/L (t=2.96,P＜0.05). Blood platelet count was reduced from (228.7±68.8)×10⁹/L to (178.3±58.2)×10⁹/L (t=3.30,P＜0.05). ALT and BUA values were also reduced from (22.4±5.3)U/L to (16.4±6.5)U/L (t=4.23,P＜0.05) and (585.3±185.6)μmol/L to (456.5±183.8)μmol/L (t=2.93,P＜0.05).Conclusion The patients with pulmonary tuberculosis are susceptible to invasive fungal infections, using a combination of treatment methods can achieve significant therapeutic effect.