矽肺纤维化研究热点和趋势的文献计量学分析

doi:10.19983/j.issn.2096-8493.20250104

摘要/Abstract

摘要：

目的: 分析矽肺纤维化领域研究发展脉络、研究热点演进规律,为后续研究方向和思路提供数据支撑。方法: 以 Web of Science(WoS) 核心合集作为主数据库,检索2000—2025年矽肺纤维化相关文献;鉴于矽肺在中国的高疾病负担特征,辅以中国知网(CNKI)同期中文文献补充检索。利用CiteSpace 6.4.R1(2023)、VOSviewer 1.6.20(2023)、Pajek 6.01(2025)、Charticulator 1.4.0(2021)等软件对所纳入文献的发文量、作者、国家、期刊、关键词等进行可视化分析。结果: 共纳入2005篇文献(WoS:961篇;CNKI:1044篇)。全球数据显示,2000—2014年间该领域发文量稳步增长,2015年后进入快速增长期,于2023年达到高峰。中国是发文量最多的国家,累计539篇(56.09%)。研究主要集中在Toxicology(毒理学)、Pharmacology& Pharmacy(药理学与药学)等学科,形成以陈杰、倪春辉、田琳、陈卫红、姚三巧、巢杰、王婧、刘和亮、杨方、徐洪、郝长付、姚武、叶俏、贾强等作者为主的合作关系。南京医科大学是被引次数最多的机构,累计被引1753次。国内外数据均显示华北理工大学是发文量最多的机构,分别累计发文234篇和71篇。国内外文献主要发表在《中国职业医学》《中国工业医学杂志》和Ecotoxicology and Environmental Safety等期刊上。关键词共现分析结果显示,国内外研究主要围绕矽肺、炎症、肺部纤维化等主题展开,早期(2000—2010年)聚焦疾病定义与暴露关联,中期(2011—2018年)深入炎症、凋亡及分子机制,近期(2019年至今)转向铁死亡等前沿靶点,TNF(肿瘤坏死因子)、CT(计算机体层摄影)、NLRP3 Inflammasome(NLRP3炎症小体)等是该领域爆发强度较大的关键词。结论: 矽肺纤维化领域的研究热点和趋势存在明显的时间演进轨迹,呈现出从暴露因素识别到免疫调控和信号通路再到多因素交互作用机制研究的特征。

关键词: 矽肺, 纤维化, 文献计量学, 可视化

Abstract:

Objective: To analyze the research hotspots and trend in silicosis fibrosis, providing a data-driven foundation for future research directions and strategies. Methods: The Web of Science (WoS) Core Collection was used as the primary database to retrieve literature from 2000—2025. Given the high disease burden of silicosis in China, the China National Knowledge Infrastructure (CNKI) was used to supplement the search with Chinese literature from the same period. CiteSpace 6.4.R1 (2023), VOSviewer 1.6.20 (2023), Pajek 6.01 (2025), and Charticulator 1.4.0 (2021) were used to conduct visual analysis of the publications, authors, countries, journals, and keywords of the included literature. Results: A total of 2005 articles were included (WoS: 961; CNKI: 1044). Global publications increased steadily from 2000—2014, followed by rapid growth in 2015, peaking in 2023. China contributed the most publications (539 articles, 56.09%). Research primarily focused on Toxicology and Pharmacology & Pharmacy, with collaborative networks centered on authors including, Chen Jie, Ni Chunhui, Tian Lin, Chen Weihong, Yao Sanqiao, Chao Jie, Wang Jing, Liu Heliang, Yang Fang, Xu Hong, Hao Changfu, Yao Wu, Ye Qiao, and Jia Qiang. Nanjing Medical University was the most cited institution, with a total of 1753 citations. North China University of Science and Technology was identified as the most prolific institution in both domestic and international databases (234 and 71 articles, respectively). The literature was mainly published in Chinese Journal of Occupational Medicine, Chinese Journal of Industrial Hygiene and Occupational Diseases, and Ecotoxicology and Environmental Safety. Keyword co-occurrence analysis revealed that research focused on silicosis, inflammation, and pulmonary fibrosis. Early studies (2000—2010) emphasized disease definition and exposure association. The middle stage (2011—2018) explored inflammation, apoptosis, and molecular mechanisms. Recent studies (2019—present) shifted to ferroptosis. TNF (Tumor Necrosis Factor), CT (Computed Tomography), and NLRP3 Inflammasome were burst keywords. Conclusion: The research hotspots and trends in silicosis fibrosis showed a clear temporal evolution, presenting a shift from exposure factor identification to immunomodulation and signaling pathways, and then to the study of multi-factor interaction mechanisms.

Key words: Silicosis, Fibrosis, Bibliometrics, Visualization

中图分类号:

李悦, 刘科良, 吕向裴, 王焕强. 矽肺纤维化研究热点和趋势的文献计量学分析[J]. 结核与肺部疾病杂志, 2026, 7(1): 59-72. doi: 10.19983/j.issn.2096-8493.20250104

Li Yue, Liu Keliang, Lyu Xiangpei, Wang Huanqiang. Bibliometric analysis of research hotspots and trends in silicosis fibrosis[J]. Journal of Tuberculosis and Lung Disease, 2026, 7(1): 59-72. doi: 10.19983/j.issn.2096-8493.20250104

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基于WoS的矽肺纤维化领域前25位参考文献

顺位	题目	第一作者	出现时间	突现强度	突现开始年份	突现结束年份
1	Basic pathogenetic mechanisms in silicosis: current understanding	Rimal B	2005	8.91	2007	2010
2	Silica binding and toxicity in alveolar macrophages	Hamilton RF Jr	2008	10.48	2009	2013
3	The Nalp3 inflammasome is essential for the development of silicosis.	Cassel SL	2008	8.18	2010	2013
4	Silicosis	Leung CC	2012	34.53	2013	2017
5	Silica induces NLRP3 inflammasome activation in human lung epithelial cells	Peeters PM	2013	7.41	2013	2018
6	Silica: A lung carcinogen	Steenland K	2014	10.81	2015	2019
7	A mechanistic review of silica-induced inhalation toxicity	Kawasaki H	2015	9.33	2016	2020
8	Silica, Silicosis, and Autoimmunity	Pollard KM	2016	17.76	2017	2021
9	Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy	Liu HJ	2016	10.44	2017	2021
10	Cell-Based Therapy for Silicosis	Lopes-Pacheco M	2016	7.61	2017	2021
11	BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis	Liu HJ	2017	10.84	2018	2021
12	Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis	Liu Y	2017	7.33	2018	2019
13	Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice	Li C	2017	10.07	2019	2022
14	Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy	Du ST	2019	8.58	2020	2023
15	Artificial stone-associated silicosis: a rapidly emerging occupational lung disease	Hoy RF	2018	7.14	2020	2023
16	Silica-related diseases in the modern world	Hoy RF	2020	19.91	2022	2025
17	Silica-associated lung disease: An old-world exposure in modern industries	Barnes H	2019	14.90	2022	2025
18	Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages	Song MY	2022	8.12	2022	2025
19	Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2	Pang JL	2021	7.64	2022	2025
20	Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017	Shi P	2020	7.13	2022	2023
21	New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis	Adamcakova J	2021	15.80	2023	2025
22	Current global perspectives on silicosis—Convergence of old and newly emergent hazards	Hoy RF	2022	9.45	2023	2025
23	Early Identification, Accurate Diagnosis, and Treatment of Silicosis	Tian L	2022	9.45	2023	2025
24	Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration	Wang MY	2022	8.77	2023	2025
25	Silicosis: An Update and Guide for Clinicians	Krefft S	2020	7.33	2023	2025

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参考文献 30

[1]	Leung CC, Ignatius TSY, Chen WH, et al. Silicosis. Lancet, 2012, 379(9830):2008-2018. doi:10.1016/S0140-6736(12)60235-9. pmid: 22534002
[2]	中华预防医学会劳动卫生与职业病分会职业性肺部疾病学组, 同济大学附属上海市肺科医院, 四川大学华西第四医院, 等. 尘肺病治疗中国专家共识(2024年版). 环境与职业医学, 2024, 41(1):1-21. doi:10.11836/JEOM23379.
[3]	Handra CM, Gurzu IL, Chirila M, et al. Silicosis: New Challenges from an Old Inflammatory and Fibrotic Disease. Front Biosci (Landmark Ed), 2023, 28(5):96. doi:10.31083/j.fbl2805096.
[4]	Raanan R, Zack O, Ruben M, et al. Occupational Silica Exposure and Dose-Response for Related Disorders-Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance. Int J Environ Res Public Health, 2022, 19(22):15010. doi:10.3390/ijerph192215010.
[5]	刘智, 罗长春, 李超, 等. 1990—2021年中国矽肺疾病负担研究. 公共卫生与预防医学, 2024, 35(6):16-20. doi:10.3969/j.issn.1006-2483.2024.06.004.
[6]	GBD 2021 Diseases and Injuries Collaborators. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990—2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet, 2024, 403(10440):2133-2161. doi:10.1016/S0140-6736(24)00757-8.
[7]	袁方, 孟诗迪, 吴梦云, 等. 中国人群矽肺的疾病负担分析及预测探讨. 中国工业医学杂志, 2024, 37(6):551-554,666. doi:10.13631/j.cnki.zggyyx.2024.06.001.
[8]	Chen C. CiteSpaceII: Detecting and visualizing emerging trends and transient patterns in scientific literature. J Am Soc Inf Sci Tec, 2006, 57(3):359-377. doi.org/10.1002/asi.20317. doi: 10.1002/asi.v57:3 URL
[9]	Van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2):523-538. doi:10.1007/s11192-009-0146-3. pmid: 20585380
[10]	Kirby T. Australia reports on audit of silicosis for stonecutters. Lancet, 2019, 393(10174):861. doi:10.1016/S0140-6736(19)30478-7. pmid: 30837133
[11]	IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC monographs on the evaluation of carcinogenic risks to humans. Ingested nitrate and nitrite, and cyanobacterial peptide toxins. IARC Monogr Eval Carcinog Risks Hum, 2010, 94:v-vii, 1-412.
[12]	IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Arsenic, metals, fibres, and dusts. IARC Monogr Eval Carcinog Risks Hum, 2012, 100(Pt C):11-465.
[13]	Wu N, Xue C, Yu S, et al. Artificial stone-associated silicosis in China: A prospective comparison with natural stone-associated silicosis. Respirology, 2020, 25(5):518-524. doi:10.1111/resp.13744. pmid: 31828940
[14]	Rumchev K, Hoang DV, Lee A. Case Report: Exposure to Respirable Crystalline Silica and Respiratory Health Among Australian Mine Workers. Front Public Health, 2022, 10:798472. doi:10.3389/fpubh.2022.798472.
[15]	Yang B, Liu X, Peng C, et al. Silicosis: from pathogenesis to therapeutics. Front Pharmacol, 2025, 16:1516200. doi:10.3389/fphar.2025.1516200.
[16]	Leung CC, Yew WW, Law WS, et al. Smoking and tuberculosis among silicotic patients. Eur Respir J, 2007, 29(4):745-750. doi:10.1183/09031936.00134706. pmid: 17182648
[17]	Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell, 2012, 149(5):1060-1072. doi:10.1016/j.cell.2012.03.042. pmid: 22632970
[18]	Căluţu IM, Smărăndescu RA, Raşcu A. Biomonitoring Exposure and Early Diagnosis in Silicosis: A Comprehensive Review of the Current Literature. Biomedicines, 2022, 11(1):100. doi:10.3390/biomedicines11010100.
[19]	Jiang PR, Cao Z, Qiu ZL, et al. Plasma levels of TNF-α and MMP-9 in patients with silicosis. Eur Rev Med Pharmacol Sci, 2015, 19(9):1716-1720.
[20]	Liu J, Song HY, Zhu BL, et al. The Effect of Silica Dust Exposure on the Serum Clara Cell Protein 16 Levels in Chinese Workers. Biomed Environ Sci, 2019, 32(1):47-50. doi:10.3967/bes2019.007. pmid: 30696540
[21]	Kohno N, Awaya Y, Oyama T, et al. KL-6, a mucin-like glycoprotein, in bronchoalveolar lavage fluid from patients with interstitial lung disease. Am Rev Respir Dis, 1993, 148(3):637-642. doi:10.1164/ajrccm/148.3.637.
[22]	Ohshimo S, Yokoyama A, Hattori N, et al. KL-6, a human MUC 1 mucin, promotes proliferation and survival of lung fibroblasts. Biochem Biophys Res Commun, 2005, 338(4):1845-1852. doi:10.1016/j.bbrc.2005.10.144.
[23]	Yu Q, Fu G, Lin H, et al. Influence of silica particles on mucociliary structure and MUC5B expression in airways of C57BL/ 6 mice. Exp Lung Res, 2020, 46(7):217-225. doi:10.1080/01902148.2020.1762804.
[24]	Pingle SK, Thakkar LR, Jawade AA, et al. Neopterin: A candidate biomarker for the early assessment of toxicity of aluminum among bauxite dust exposed mine workers. Indian J Occup Environ Med, 2015, 19(2):102-109. doi:10.4103/0019-5278.165332. pmid: 26500413
[25]	Ma Z, Zhao C, Chen Q, et al. Antifibrotic effects of a novel pirfenidone derivative in vitro and in vivo. Pulm Pharmacol Ther, 2018, 53:100-106. doi:10.1016/j.pupt.2018.10.006.
[26]	Su W, Liang Y, Meng Z, et al. Inhalation of Tetrandrine-hydroxypropyl-β-cyclodextrin Inclusion Complexes for Pulmonary Fibrosis Treatment. Mol Pharm, 2020, 17(5):1596-1607. doi:10.1021/acs.molpharmaceut.0c00026.
[27]	Chen MH, Chen JC, Tsai CC, et al. Sho-saiko-to prevents liver fibrosis induced by bile duct ligation in rats. Am J Chin Med, 2004, 32(2):195-207. doi:10.1142/S0192415X04001862.
[28]	Li H. Advances in anti hepatic fibrotic therapy with Traditional Chinese Medicine herbal formula. J Ethnopharmacol, 2020, 251:112442. doi:10.1016/j.jep.2019.112442.
[29]	Zhang E, Yang Y, Chen S, et al. Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibrosis potentially by attenuating Wnt/β-catenin signaling in rats. Stem Cell Res Ther, 2018, 9(1):311. doi:10.1186/s13287-018-1045-4. pmid: 30428918
[30]	Skibba M, Drelich A, Poellmann M, et al. Nanoapproaches to Modifying Epigenetics of Epithelial Mesenchymal Transition for Treatment of Pulmonary Fibrosis. Front Pharmacol, 2020, 11:607689. doi:10.3389/fphar.2020.607689.

顺位	研究学科(WoS categories)	发文量(篇)
1	毒理学(toxicology)	217
2	药理学与药学(pharmacology & pharmacy)	131
3	呼吸系统(respiratory system)	122
4	公共、环境与职业健康(public, environmental & occupational health)	120
5	环境科学(environmental sciences)	111
6	医学研究与实验(medicine, research & experimental)	97
7	生物化学与分子生物学(biochemistry & molecular biology)	90
8	细胞生物学(cell biology)	76
9	免疫学(immunology)	64
10	交叉科学(multidisciplinary sciences)	43

顺位	机构	所属国家	发文量(篇)	被引频次	篇均被引频次
1	华北理工大学	中国	71	910	12.82
2	南京医科大学	中国	56	1753	31.30
3	中国医科大学	中国	43	1552	36.09
4	首都医科大学	中国	43	773	17.98
5	美国职业安全卫生研究所	美国	39	1678	43.03
6	郑州大学	中国	33	456	13.82
7	里约热内卢联邦大学	巴西	25	871	34.84
8	华中科技大学	中国	24	1363	56.79
9	新乡医学院	中国	24	285	11.88
10	东南大学	中国	23	823	35.78

顺位	国家	发文量(篇)	被引频次	篇均被引频次
1	中国	539	11194	20.77
2	美国	181	7382	40.78
3	日本	45	1179	26.20
4	巴西	44	1243	28.25
5	澳大利亚	29	919	31.69
6	加拿大	27	807	29.89
7	土耳其	24	631	26.29
8	印度	24	220	9.17
9	意大利	23	258	11.22
10	德国	21	731	34.81

顺位	期刊名称	发文量(篇)	被引频次	影响因子(2024年)
1	Ecotoxicology and Environmental Safety	44	578	6.1
2	International Immunopharmacology	26	278	4.7
3	Toxicology Letters	26	574	2.9
4	International Journal of Molecular Sciences	25	595	4.9
5	Toxicology and Applied Pharmacology	19	521	3.4
6	American Journal of Industrial Medicine	16	220	3.1
7	Plos One	16	772	2.6
8	Scientific Reports	16	508	3.9
9	Occupational and Environmental Medicine	13	361	3.1
10	Biomedicine and Pharmacology	12	211	7.5