Research progress on the mechanism of there relationship between asthma and pertussisin children

doi:10.19983/j.issn.2096-8493.20220136

Abstract

Abstract:

Bronchial asthma is a common chronic respiratory disease, and its main pathological mechanism is airway inflammation and airway remodeling, which is associated with a variety of respiratory pathogenic infections. In recent years, the relationship between pertussis and asthma has been paid more and more attention because of the recurrence of pertussis all over the world. The correlation between pertussis and asthma has been suggested by a large number of clinical studies, but the related mechanism is not yet clear. The molecular, cellular and tissue-level mechanisms involved in these two mechanisms are reviewed in this paper. Pertussis infection can cause airway inflammation and airway remodeling at the molecular level. After pertussis infection,pertussis toxin can induce cytoskeletal reorganization, and then lose the integrity of cell junctions, trigger airway inflammation, and promote airway remodeling, at the cellular level. Both pertussis toxin and tracheal cytotoxin can cause significant airway histological changes, including extrusion and destruction of ciliated respiratory epithelium by tracheal cytotoxin, leading to airway inflammation and airway remodeling.

Key words: Children, Asthma, Pneumonia

CLC Number:

Yan Jinyan, Li Xiaomin, Ma Xiang. Research progress on the mechanism of there relationship between asthma and pertussisin children[J]. Journal of Tuberculosis and Lung Disease , 2023, 4(1): 78-84. doi: 10.19983/j.issn.2096-8493.20220136

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