Journal of Tuberculosis and Lung Disease ›› 2022, Vol. 3 ›› Issue (1): 27-32.doi: 10.19983/j.issn.2096-8493.20210138
• Original Articles • Previous Articles Next Articles
CAI Jun-li1, JING Rui1, ZHANG Wen-qian1, WU Hong-yan1, LIU Xiao-hua2()
Received:
2021-10-29
Online:
2022-02-20
Published:
2022-02-24
Contact:
LIU Xiao-hua
E-mail:2006liuxiaohua@sina.com
CLC Number:
CAI Jun-li, JING Rui, ZHANG Wen-qian, WU Hong-yan, LIU Xiao-hua. Drug-resistant tuberculosis among patients in Ji’nan from 2016 to 2020[J]. Journal of Tuberculosis and Lung Disease , 2022, 3(1): 27-32. doi: 10.19983/j.issn.2096-8493.20210138
Add to citation manager EndNote|Ris|BibTeX
URL: http://www.jtbld.cn/EN/10.19983/j.issn.2096-8493.20210138
年份 | 培养阳 性例数 | 总耐药[例 (耐药率,%)] | 单耐药[例 (耐药率,%)] | 耐多药[例 (耐药率,%)] | 准广泛耐药[例 (耐药率,%)] | 其他耐药[例 (耐药率,%)] |
---|---|---|---|---|---|---|
2016 | 92 | 46(50.00) | 13(14.13) | 28(30.43) | 5(5.43) | 0(0.00) |
2017 | 64 | 32(50.00) | 10(15.62) | 16(25.00) | 6(9.38) | 0(0.00) |
2018 | 135 | 33(24.44) | 12(8.89) | 11(8.15) | 2(1.48) | 8(5.93) |
2019 | 359 | 58(16.16) | 33(9.19) | 11(3.06) | 3(0.84) | 11(3.06) |
2020 | 454 | 105(23.13) | 44(9.69) | 19(4.19) | 1(0.22) | 41(9.03) |
合计 | 1104 | 274(24.82) | 112(10.14) | 85(7.70) | 17(1.54) | 60(5.43) |
人口学特征 | 例数(1104例) | 耐药例数(274例) | 耐药率(%) | χ2值 | P值 |
---|---|---|---|---|---|
性别 | 0.120 | 0.729 | |||
男性 | 805 | 202 | 25.09 | ||
女性 | 299 | 72 | 24.08 | ||
年龄组(岁) | 10.177 | 0.017 | |||
14~20 | 48 | 3 | 6.25 | ||
21~40 | 359 | 98 | 27.30 | ||
41~60 | 290 | 70 | 24.14 | ||
61~95 | 407 | 103 | 25.31 | ||
职业 | 10.714 | 0.057 | |||
农民和民工 | 582 | 138 | 23.71 | ||
工人 | 119 | 29 | 24.37 | ||
行政事业单位人员 | 102 | 32 | 31.37 | ||
离退休人员 | 77 | 21 | 27.27 | ||
学生 | 72 | 9 | 12.50 | ||
其他 | 152 | 45 | 29.61 | ||
居住地 | 21.625 | 0.001 | |||
主城区 | 400 | 113 | 28.25 | ||
长清区 | 107 | 29 | 27.10 | ||
章丘区 | 158 | 51 | 32.28 | ||
莱芜区 | 199 | 31 | 15.58 | ||
济阳区 | 81 | 18 | 22.22 | ||
钢城区 | 51 | 6 | 11.76 | ||
郊区两县 | 108 | 26 | 24.07 | ||
患者分类 | 40.843 | <0.001 | |||
初治患者 | 950 | 204 | 21.47 | ||
复治患者 | 154 | 70 | 45.45 |
变量 | β值 | $\bar{x}±s$值 | Wald χ2值 | P值 | OR值 | 95%CI值 | ||
---|---|---|---|---|---|---|---|---|
上限 | 下限 | |||||||
年龄组(岁) | ||||||||
14~20 | 1.000 | |||||||
21~40 | 1.480 | 0.612 | 5.857 | 0.016 | 4.394 | 1.325 | 14.570 | |
41~60 | 0.011 | 0.173 | 0.008 | 0.959 | 0.985 | 0.669 | 1.527 | |
61~95 | 0.199 | 0.186 | 1.080 | 0.316 | 1.213 | 0.827 | 1.800 | |
地区分布 | ||||||||
主城区 | 1.000 | |||||||
长清区 | -0.349 | 0.264 | 1.742 | 0.187 | 0.706 | 0.420 | 1.184 | |
章丘区 | -0.221 | 0.326 | 0.460 | 0.498 | 0.802 | 0.424 | 1.518 | |
莱芜区 | -0.433 | 0.293 | 2.180 | 0.140 | 0.648 | 0.365 | 1.152 | |
济阳区 | 0.529 | 0.308 | 2.948 | 0.086 | 1.697 | 0.928 | 3.103 | |
钢城区 | 0.177 | 0.363 | 0.239 | 0.625 | 1.194 | 0.586 | 2.432 | |
郊区两县 | 0.863 | 0.501 | 2.969 | 0.085 | 2.371 | 0.888 | 6.329 | |
患者分类 | ||||||||
初治患者 | 1.000 | |||||||
复治患者 | 1.187 | 0.189 | 39.615 | <0.001 | 3.276 | 2.264 | 4.740 |
[1] |
Molie T, Teklemariam Z, Klinkenberg E, et al. Intensive phase treatment outcome and associated factors among patients treated for multi drug resistant tuberculosis in Ethiopia: a retrospective cohort study. BMC Infect Dis, 2019, 19(1):818. doi: 10.1186/s12879-019-4411-7.
doi: 10.1186/s12879-019-4411-7 URL |
[2] |
Conradie F, Diacon AH, Ngubane N, et al. Treatment of Highly Drug-Resistant Pulmonary Tuberculosis. N Engl J Med, 2020, 382(10):893-902. doi: 10.1056/NEJMoa1901814.
doi: 10.1056/NEJMoa1901814 URL |
[3] |
MacPherson DW, Gushulak BD. Balancing prevention and screening among international migrants with tuberculosis: population mobility as the major epidemiological influence in low-incidence nations. Public Health, 2006, 120(8):712-723. doi: 10.1016/j.puhe.2006.05.002.
doi: 10.1016/j.puhe.2006.05.002 pmid: 16828821 |
[4] |
王美花, 张文茜, 景睿, 等. 2010—2019年济南市肺结核流行特征分析. 结核与肺部疾病杂志, 2020, 1(3):262-264. doi: 10.3969/j.issn.2096-8493.2020.03.011.
doi: 10.3969/j.issn.2096-8493.2020.03.011 |
[5] | 赵雁林, 逄宇. 结核病实验室检验规程. 北京: 人民卫生出版社, 2015. |
[6] |
中国防痨协会. 耐药结核病化学治疗指南(2019年简版). 中国防痨杂志, 2019, 41(10):1025-1073. doi: 10.3969/j.issn.1000-6621.2019.10.001.
doi: 10.3969/j.issn.1000-6621.2019.10.001 |
[7] | 全国第五次结核病流行病学抽样调查技术指导组, 全国第五次结核病流行病学抽样调查办公室. 2010年全国第五次结核病流行病学抽样调查报告. 中国防痨杂志, 2012, 34(8):485-508. |
[8] |
Kumar P, Kumar P, Balooni V, et al. Genetic mutations associated with rifampicin and isoniazid resistance in MDR-TB patients in North-West India. Int J Tuberc Lung Dis, 2015, 19(4):434-439. doi: 10.5588/ijtld.14.0596.
doi: 10.5588/ijtld.14.0596 pmid: 25859999 |
[9] |
李永文, 李新旭, 耿红, 等. 山东省结核分枝杆菌的耐药流行状况. 中华结核和呼吸杂志, 2013, 36(9):667-670. doi: 10.3760/cma.j.issn.1001-0939.2013.09.007.
doi: 10.3760/cma.j.issn.1001-0939.2013.09.007 |
[10] |
王忠东, 张华强, 薛白, 等. 青岛地区耐药结核病流行现状及危险因素分析. 中国公共卫生, 2015, 31(9):1222-1224. doi: 10.11847/zgggws2015-31-09-35.
doi: 10.11847/zgggws2015-31-09-35 |
[11] |
Tao NN, He XC, Zhang XX, et al. Trends and characteristics of drug-resistant tuberculosis in rural Shandong, China. Int J Infect Dis, 2017, 65:8-14. doi: 10.1016/j.ijid.2017.09.019.
doi: 10.1016/j.ijid.2017.09.019 URL |
[12] |
范大鹏, 岳永宁, 张艳, 等. 2014—2018年杭州市肺结核患者的耐药情况及其影响因素分析. 中国防痨杂志, 2021, 43(1):72-79. doi: 10.3969/j.issn.1000-6621.2021.01.014.
doi: 10.3969/j.issn.1000-6621.2021.01.014 |
[13] |
蔡春葵, 吕欣桐, 李刚, 等. 2012—2018年大连市肺结核患者耐药状况分析. 结核病与肺部健康杂志, 2019, 8(4):265-271. doi: 10.3969/j.issn.2095-3755.2019.04.007.
doi: 10.3969/j.issn.2095-3755.2019.04.007 |
[14] |
白桦, 郭婧玮, 胡培磊, 等. 2014—2018年湖南省耐药监测点结核分枝杆菌耐药监测结果分析. 中国防痨杂志, 2021, 43(4):365-369. doi: 10.3969/j.issn.1000-6621.2021.04.012.
doi: 10.3969/j.issn.1000-6621.2021.04.012 |
[15] |
Ahmed S, Shukla I, Fatima N, et al. Profile of drug-resistant-conferring mutations among new and previously treated pulmonary tuberculosis cases from Aligarh region of Northern India. Int J Mycobacteriol, 2018, 7(4):315-327. doi: 10.4103/ijmy.ijmy_98_18.
doi: 10.4103/ijmy.ijmy_98_18 URL |
[16] |
程曦, 李亚斐, 饶英, 等. 2271例结核病患者耐药情况的流行病学特征分析. 重庆医学, 2015, 44(12):1635-1637. doi: 10.3969/j.issn.1671-8348.2015.12.016.
doi: 10.3969/j.issn.1671-8348.2015.12.016 |
[17] |
Wu B, Yu Y, Du C, et al. Epidemiology of drug-resistant tuberculosis in Chongqing, China: A retrospective observational study from 2010 to 2017. PLoS One, 2019, 14(12):e0216018. doi: 10.1371/journal.pone.0216018.
doi: 10.1371/journal.pone.0216018 URL |
[18] |
Tripathy S, Kumar R, Singh SD. Prevalence of Multidrug Resistant Pulmonary Tuberculosis in North Bihar. J Clin Diagn Res, 2015, 9(11): LC09-12. doi: 10.7860/JCDR/2015/14024.6793.
doi: 10.7860/JCDR/2015/14024.6793 |
[19] |
Chan-Yeung M, Kam KM, Leung CC, et al. Population-based prospective molecular and conventional epidemiological study of tuberculosis in Hong Kong. Respirology, 2006, 11(4):442-448. doi: 10.1111/j.1440-1843.2006.00871.x.
doi: 10.1111/j.1440-1843.2006.00871.x pmid: 16771914 |
[20] |
杜巧丽, 杜昌廷, 杨健, 等. 2016—2018 年中国西部地区结核分枝杆菌耐药率及影响因素分析. 疾病监测, 2021, 36(5):495-500. doi: 10.3784/jbjc.202010290446.
doi: 10.3784/jbjc.202010290446 |
[21] |
Lin M, Zhong Y, Chen Z, et al. High incidence of drug-resis-tant Mycobacterium tuberculosis in Hainan Island, China. Trop Med Int Health, 2019, 24(9):1098-1103. doi: 10.1111/tmi.13285.
doi: 10.1111/tmi.13285 URL |
[22] |
Huai P, Huang X, Cheng J, et al. Proportions and Risk Factors of Developing Multidrug Resistance Among Patients with Tuberculosis in China: A Population-Based Case-Control Study. Microb Drug Resist, 2016, 22(8):717-726. doi: 10.1089/mdr.2015.0186.
doi: 10.1089/mdr.2015.0186 URL |
[23] |
闫莉, 关福源, 钟明浩, 等. 2018年结核病耐药情况及影响因素分析. 中国实验诊断学, 2020, 24(4):539-542. doi: 10.3969/j.issn.1007-4287.2020.04.001.
doi: 10.3969/j.issn.1007-4287.2020.04.001 |
[1] | ZHAO Guang-qiang, WANG Bin, CHEN Yun-ting, LIANG Wen-xiao, LIANG Gui-lin, LIN Rong. Clinical efficacy and safety evaluation of cryointerventional therapy under electronic bronchoscope for patients with bronchial tuberculosis [J]. Journal of Tuberculosis and Lung Disease, 2022, 3(1): 14-18. |
[2] | CHEN Zhuang-hao, LIN Jian-xiong, ZENG Li-xiang. Clinical effect of short-term regimen containing levofloxacin in the treatment of newly diagnosed bacteria-positive pulmonary tuberculosis [J]. Journal of Tuberculosis and Lung Disease, 2022, 3(1): 19-21. |
[3] | LI Yong, LU Li-ping, LI Jin, ZOU Jin-yan. Analysis of willingness and effect of tuberculosis assistant APP and electronic kit in pulmonary tuberculosis patients [J]. Journal of Tuberculosis and Lung Disease, 2022, 3(1): 22-26. |
[4] | REN Hui-li, PAN Jing-jie, ZHANG Hong, LIANG Rui-run, FANG Wei-jun. CT features of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis patients with different Traditional Chinese Medicine syndromes [J]. Journal of Tuberculosis and Lung Disease, 2022, 3(1): 4-8. |
[5] | DONG Hang, DU Ying-rong. Progress in clinical research on comorbidity of pulmonary tuberculosis and diabetes mellitus [J]. Journal of Tuberculosis and Lung Disease, 2022, 3(1): 65-69. |
[6] | LIU Hui-min, TIAN Yao, BEI Cheng-li, FU Man-jiao. Application and prospect of immunological detection technology for active pulmonary tuberculosis [J]. Journal of Tuberculosis and Lung Disease, 2022, 3(1): 70-74. |
[7] | TAO Tao, WU Peng, BAO Xiao-li, TANG Nan. The diagnostic value of ultrasound-guided pleural biopsy and medical thoracoscopy on detecting tuberculous pleurisy [J]. Journal of Tuberculosis and Lung Disease, 2022, 3(1): 9-13. |
[8] | SUN Shan-hua, LI Yan-yuan, TAO Li-ying, GAO Zhi-dong, ZHANG Hong-wei, XU Yan, CHEN Xi. Characteristics of report, registration and epidemiolog from children pulmonary tuberculosis in Beijing during 2011-2020 [J]. Journal of Tuberculosis and Lung Disease, 2021, 2(4): 305-310. |
[9] | XIAO Xiao, CHEN Jing, RAO Li-xin, JIANG Yue, LI Jin, ZHAO Ya-meng, SHEN Xin. A study of detection methods of latent Mycobacterium tuberculosis infection in close contacts of active tuberculosis patients among college students [J]. Journal of Tuberculosis and Lung Disease, 2021, 2(4): 311-316. |
[10] | OU Qing-ye, ZHANG Wei-hua, ZHAO Wen-jun, KUANG Jun-rong. Investigation on knowledge,attitude,practice of tuberculosis among students in secondary vocational school in Zhuhai City [J]. Journal of Tuberculosis and Lung Disease, 2021, 2(4): 317-321. |
[11] | GUO Qiang, MA Ling, LI Jiang-hong, ZHANG Lei-lei, SHAO Fu-rong, ZHANG Lan, YANG Shu-min. Investigation and analysis of the implementation status of tuberculosis prevention and control in schools in Gansu Province during 2015 to 2020 [J]. Journal of Tuberculosis and Lung Disease, 2021, 2(4): 322-325. |
[12] | HAO Rui-xia, LI Bing, LIU Min, BAI Jun, QI Dan. Analysis of epidemiological characteristics of pulmonary tuberculosis among students in Ordos, Inner Mongolia Autonomous Region from 2010 to 2019 [J]. Journal of Tuberculosis and Lung Disease, 2021, 2(4): 326-329. |
[13] | WEI Jian-hua, GUO Tao, GAO Xiao-na, WU Wei, GUO Lei. Clinical characteristics and treatment outcome of 151 hospitalized students with tuberculosis [J]. Journal of Tuberculosis and Lung Disease, 2021, 2(4): 330-335. |
[14] | CHEN Jing, ZHAO Peng. Analysis of risk factors of anti-tuberculosis drug-induced liver injury in 7043 tuberculosis patients in Guiyang [J]. Journal of Tuberculosis and Lung Disease, 2021, 2(4): 335-339. |
[15] | FANG Lan-jun, WU Hui-zhong, ZHOU Fang-jing, SU Jing, WEN Wen-pei, ZHOU Lin, CHEN Liang. Investigation of tuberculosis screening and core knowledge among elderly people in elderly care institutions [J]. Journal of Tuberculosis and Lung Disease, 2021, 2(4): 340-346. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||