The new era of systematic immunology of tuberculosis

doi:10.3969/j.issn.2096-8493.2020.03.002

Abstract

Abstract:

With the breakthrough of key technologies, the achievements based on the gene knockout MTB mutant library and animal models of tuberculosis, enable the development of systematic immunology of tuberculosis (SIT). In this review, we described the data framework of SIT, and we also discussed how the SIT database will benefit the prosperity of novel vaccine and drug development against the tuberculosis disease.

Key words: Tuberculosis, Immunologic techniques, Animal models, Gene knockout techniques, Vaccines, Systematic immunology

ZHU Guo-feng, LIU Xiao-qing. The new era of systematic immunology of tuberculosis[J]. Journal of Tuberculosis and Lung Disease , 2020, 1(3): 195-212. doi: 10.3969/j.issn.2096-8493.2020.03.002

Figures/Tables 7

References 40

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领域	数据类型		数据构成	结核病比较免疫学数据贡献	价值意义
临床	结核病临床分类患者免疫数据		临床结核病体液免疫学(B细胞) 临床结核病细胞免疫学(T细胞)	临床应用	理论方面: 形成“结核病比较免疫学”
核心实验技术	结核病动物模型	猴子	猴子结核病系统免疫学		应用方面:
		豚鼠	豚鼠结核病系统免疫学	结核病比较免疫学	(1)诊断: 高敏感度免疫诊断技术
		小鼠	小鼠结核病系统免疫学	核心数据框架	(2)疫苗: 保护性免疫反应数据库
	MTB基因敲除	MTB	MTB基因敲除突变体(约4000个+野生型H37Rv)		(3)药物: 宿主免疫调控及新药物