Screening and follow-up of tuberculosis among undergraduate freshmen in Haidian District, Beijing, 2011—2015

doi:10.3969/j.issn.2096-8493.2020.01.011

Abstract

Abstract:

Objective To analyze the tuberculosis (TB) screening situation of undergraduate freshmen and follow-up during undergraduate study in Haidian District of Beijing from 2011 to 2015. Methods A total of 266770 undergraduate freshmen from 30 universities in Haidian District of Beijing from 2011 to 2015 were selected as the survey objects. All the TB screening work was carried out in Haidian District, Beijing. The basic information and TB screening information were collected and analyzed, including tuberculin pure protein derivative (PPD) test results, chest X-ray examination results and follow-up information. Results Of the 266770 respondents, 263021 completed TB screening. Among 262742 who completed PPD screening, the strong positive rate of PPD was 5.46% (14357/262742). A total of 189 cases with TB were detected in the freshmen who received TB screening, and the detection rate was 71.86/100000 (189/263021). During the 4 years of undergraduate education, 423 cases were diagnosed with TB cumulatively, with a cumulative incidence rate of 158.68/100000 (423/266581). Freshmen with a strong positive PPD test for admission screening had the highest cumulative incidence (576.00/100000 (82/14236)) during the undergraduate period. During the undergraduate period, there were 28 cases of tuberculosis clustering epidemic, 4751 close contacts were screened, 69 patients were detected, and the recurrence rate was 1.45% (69/4751). Conclusion Universities should strengthen the mobilization of TB screening for freshmen, improve the completion rate of TB screening for freshmen, strengthen the symptom monitoring of strong PPD positive students in school, strengthen the management of rest and resumption of school for patients with confirmed tuberculosis, and timely screen close contacts.

Key words: Tuberculosis, pulmonary, Universities, Tuberculin test, Incidence, Contact tracing

LIU Xi, LI Jie. Screening and follow-up of tuberculosis among undergraduate freshmen in Haidian District, Beijing, 2011—2015[J]. Journal of Tuberculosis and Lung Disease , 2020, 1(1): 49-54. doi: 10.3969/j.issn.2096-8493.2020.01.011

Figures/Tables 3

References 12

[1]	郭建丽, 徐勤, 刘玉清. 北京市海淀区33所大学新生的结核感染状况调查. 中华预防医学杂志, 2006,40(5):355-358.
[2]	孙闪华, 高志东, 李亚敏, 等. 2005—2014年北京市肺结核流行特征分析. 公共卫生与预防医学, 2016,27(4):6-9.
[3]	张华君. 2014—2018年江苏宜兴市学生肺结核疫情分析. 公共卫生与预防医学, 2020,31(2):102-104. doi: 10.3969/j.issn.1006-2483.2020.02.025.
[4]	陈卉, 夏愔愔, 张灿有, 等. 2014—2018年全国学生肺结核疫情变化趋势及特征分析. 中国防痨杂志, 2019,41(6):662-668. doi: 10.3969/j.issn.1000-6621.2019.06.013.
[5]	肖筱, 陈静, 李向群, 等. 2009—2017年上海市学生肺结核疫情特征分析. 中国防痨杂志, 2020,42(5):498-502. doi: 10.3969/j.issn.1000-6621.2020.05.015.
[6]	刘梦阳, 张英杰, 马圆, 等. 北京市空气质量指数与结核病发病关系的时间序列研究. 中华流行病学杂志, 2018,39(12):1565-1569. doi: 10.3760/cma.j.issn.0254-6450.2018.12.006.
[7]	王文琴, 梁日成, 余小华, 等. 大学生群体肺结核患病的流行病学研究,以广西大学大学生为研究案例. 基因组学与应用生物学, 2017,36(6):2248-2254. doi: 10.13417/j.gab.036.002248.
[8]	梁瑞英, 徐伟, 吴春萍. 北京市朝阳区2013—2015年高校新生结核菌潜伏感染现状及发病情况. 中国学校卫生, 2019,40(9):1373-1375,1379. doi: 10.16835/j.cnki.1000-9817.2019.09.026.
[9]	李阳, 周昌明, 郑亦慧, 等. 在结核病患者儿童/青少年密切接触者中开展结核病预防性治疗的可行性定性研究. 上海预防医学, 2018,30(3):170-175. doi: 10.19428/j.cnki.sjpm.2018.18663.
[10]	谭守勇. 重视学校复学肺结核患者管理. 中国防痨杂志, 2020,42(2):85-87.doi: 10.3969/j.issn.1000-6621.2020.02.001.
[11]	钱冰, 王莉丽, 曹红, 等. 2013—2017年合肥市肺结核流行特征分析. 现代预防医学, 2020,47(3):528-531.
[12]	张晓龙, 蒋骏, 傅颖, 等. 江苏省苏州市学校结核病聚集性疫情接触者筛查分析. 中国热带医学, 2020,20(2):139-141,151. doi: 10.13604/j.cnki.46-1064/r.2020.02.10.

特征	行PPD筛查者(名)	强阳性(名)	强阳性率(%)	χ²值	P值
性别				46.10	<0.01
男	126883	6538	5.15
女	135859	7819	5.76
年龄组(岁)				16.92	<0.01^b
<17	4646	225	4.84
17~	39599	1890	4.77
18~	150463	7626	5.07
19~	50436	3281	6.51
20~	17598	1335	7.59
民族				121.33	<0.01
汉族	228201	12036	5.27
少数民族	34541	2321	6.72
生源地区^a				125.16	<0.01
东部	124630	6160	4.94
中部	68115	3799	5.58
西部	66502	4061	6.11
户籍所在地				6.7	0.010
北京市	50320	2631	5.23
非北京市	212422	11726	5.52
年份				56.13	<0.01^b
2011	48444	4028	8.31
2012	54756	5120	9.35
2013	57214	2388	4.17
2014	52886	1473	2.79
2015	49442	1348	2.73

特征	行筛查者(名)	检出患者(例)	检出率(/10万)	χ²值	P值
性别				2.92	0.090
男	127004	103	81.10
女	136017	86	63.23
年龄组(岁)				2.37	0.009^b
<17	4649	3	64.53
17~	39627	30	75.71
18~	150631	94	62.40
19~	50492	35	69.32
20~	17622	27	153.22
民族				13.62	<0.01
汉族	228430	147	64.35
少数民族	34591	42	121.42
生源地区^a				30.71	<0.01
东部	124776	54	43.28
中部	68163	57	83.62
西部	66585	74	111.14
户籍所在地				21.73	<0.01
北京市	50398	11	21.83
非北京市	212623	178	83.72
年份				0.02	0.890^b
2011	48459	41	84.61
2012	54769	36	65.73
2013	57293	44	76.80
2014	52987	29	54.73
2015	49513	39	78.77

特征	行筛查者(名)	检出患者(例)	累积发病率(/10万)	χ²值	P值
性别				60.46	<0.01
男	128855	282	218.85
女	137726	141	102.38
民族				25.61	<0.01
汉族	231564	330	142.51
少数民族	35017	93	265.59
生源地区^a				54.04	<0.01
东部	126765	135	106.50
中部	68889	120	174.19
西部	67327	167	248.04
户籍所在地				21.73	<0.01
北京市	51447	33	64.14
非北京市	215134	390	181.28
PPD试验				14.40	<0.01^b
阴性	205604	223	108.46
阳性	42742	111	259.70
强阳性	14236	82	576.00

[1]	DAI Zhi-song, LIN Shu-fang, WEI Shu-zhen, ZHOU Yin-fa. Analysis of epidemiological characteristics of pulmonary tuberculosis in Fujian Province from 2011 to 2019 [J]. Journal of Tuberculosis and Lung Disease, 2020, 1(3): 249-255.
[2]	WANG Mei-hua, ZHANG Wen-qian, JING Rui, ZHANG Guang-li. Analysis of epidemiological characteristics of pulmonary tuberculosis in Ji’nan from 2010 to 2019 [J]. Journal of Tuberculosis and Lung Disease, 2020, 1(3): 262-264.
[3]	ZENG Yu-huan, CHEN Jian-ren, YAO Zheng-gang, ZHANG Chen-chen, WEN Wen-pei. Investigation of a tuberculosis outbreak in an university in Yangjiang prefecture, Guangdong Province [J]. Journal of Tuberculosis and Lung Disease, 2020, 1(2): 154-158.
[4]	DAI Zhi-song, LIN Shu-fang, WEI Shu-zhen, CHEN Dai-quan.. Analysis of the reported incidence of pulmonary tuberculosis among students in Fujian Province from 2011 to 2019 [J]. Journal of Tuberculosis and Lung Disease, 2020, 1(2): 159-164.
[5]	JING Rui, WANG Mei-hua, CAI Jun-li, ZHANG Wen-qian, REN Wen. Analysis of screening results of close contacts of tuberculosis patients in schools in Ji’nan in 2018 [J]. Journal of Tuberculosis and Lung Health, 2020, 9(1): 64-67.
[6]	LI Hong-xing, LIU Dong-qin, YANG Chun-xia, CHEN Guang-qing, LI Zhang-yu, LI Jie. Analysis of the results of two skin tests of tuberculin for different reasons [J]. Journal of Tuberculosis and Lung Disease, 2020, 1(1): 93-95.
[7]	WANG Xi-jiang,WANG Sen-lu,ZHAO Zhen,ZHANG Jing, ,TAI Xin-rong,CUI Yan.. Analysis of epidemic features of smear-positive pulmonary tuberculosis in Xinjiang Uygur Autonomous Region from 2010 to 2017 [J]. Journal of Tuberculosis and Lung Health, 2019, 8(3): 209-217.
[8]	LIU An-heng,GUO Chao,HUANG Zheng-qin,CAI Ling-ling. Analysis on epidemic characteristics of pulmonary tuberculosis among students in Tengchong City of Yunnan Province, 2014—2018 [J]. Journal of Tuberculosis and Lung Health, 2019, 8(3): 229-231.
[9]	Xiao-ting CAI,Yu-hua DU,Jing ZHONG,Gang HE,Kun-hong JIANG. Epidemiological characteristics of tuberculosis patients in Haizhu District of Guangzhou from 2014 to 2018 [J]. Journal of Tuberculosis and Lung Health, 2019, 8(2): 100-105.
[10]	Qian WANG,Bin LUO,Xiu-lei ZHANG,Xiao-yan GUO. Analysis of the incidence of pulmonary tuberculosis among students in Shandong Province from 2011 to 2016 [J]. Journal of Tuberculosis and Lung Health, 2019, 8(2): 86-89.
[11]	Jin LI,Li-ping LU,Xiao-qin GUO,Yong LI,Jin-yan ZOU. Analysis on tuberculosis epidemical situation and screening results of close contacts in schools of Songjiang District of Shanghai in 2018 [J]. Journal of Tuberculosis and Lung Health, 2019, 8(2): 94-99.
[12]	Juan WANG,Xiang XU,Jing JIANG,Mei-xia. YANG. Analysis on registration and outcome of diabetes mellitus complicated with pulmonary tuberculosis patients in Xuhui District of Shanghai from 2013 to 2017 [J]. Journal of Tuberculosis and Lung Health, 2019, 8(1): 29-32.
[13]	Zhi ZHANG,Wei WANG,Guo-qin ZHANG,Wen-liang WEI. Analysis of tuberculosis case-finding and incidence in prisoners in Tianjin Prison System during 2011 to 2017 [J]. Journal of Tuberculosis and Lung Health, 2018, 7(4): 275-278.
[14]	Bi-bo ZHANG,Hong-hai LI. Analysis of epidemic situation of senile pulmonary tuberculosis in Heilongjiang Province from 2011 to 2017 [J]. Journal of Tuberculosis and Lung Health, 2018, 7(4): 293-297.
[15]	Wen-jie ZHOU,Li ZHONG,Xing-neng LUO. Epidemiology of tuberculosis in the elderly in Shapingba District in Chongqing, 2008—2017 [J]. Journal of Tuberculosis and Lung Health, 2018, 7(3): 171-175.