Abstract: Objective To describe the drug resistant profile among the diagnosed tuberculosis cases, identify the risk factors in terms of their socio-demographic and clinical characteristics in Zigong city, Sichuan province and to provide the knowledge evidence for anti-TB strategies.Methods The subjects of the study were all the diagnosed TB patients registered in 6 districts of Zigong city within one year between 2010 and 2011, including 235 patients with new cases and retreatment cases. Of 232 eligible cases enrolled within the study period, 25 were resistant to at least one of 4 drugs (isoniazid, rifampicin, ethambutol, streptomycin) and 25 were simultaneously resistant to INH and RFP or referred to multidrug-resistant tuberculosis (MDR-TB). The Questionnaire interview was conducted by the trained interviewers to acquire the subjects’ socio-demographic and clinical information.Results Among 232 eligible subjects analyzed the socio-economic and clinical factors, MDR-TB was observed in 21.4% (9/42) female patients and 8.4% (16/190) male patients(OR＝2.72; 95%CI＝1.062-6.957). The population with an-nual income less than 4200 RMB had the significantly high proportion of MDR-TB compared to those with annual income more than 4200 RMB (35.1% vs 10.0%; OR＝4.87; 95%CI＝2.278-10.784). The previously treated patients were in higher risk of developing MDR than newly treated patients. Moreover, among the previously treated patients, the patient with previous treatment more than once were more likely to develop MDR-TB than the patients with previous treatment once (46.2% vs 23.1%; χ²=9.39, P=0.009).Conclusion Female, previously treated TB patients and those with low income were at a higher risk of developing MDR-TB and it should be concerned as the emphasis for the anti-MDR-TB activities in Zigong, Sichuan province.