Abstract:

Ninety cases of multidrug-resistant pulmonary tuberculosis admitted from May 2015 to July 2016 at Qianshan Hospital of Anshan City, Liaoning Province were selected in this study. The subjects were divided into control group and observation group by random number table method (45 cases in each group). After approval by the Ethics Committee, subjects in the control group was treated with chemotherapy alone, whereas those in the observation group received local drug administration by bronchfiberscope combined with chemotherapy. The clinical efficacy of the two groups was compared. The overall effective rate was 68.89% (31/45) in the observation group and 44.44% (20/45) in the control group; the difference was statistically significant (χ ²=5.48, P=0.019). The overall rate of improvement in lesions was 84.44% (38/45) in the observation group and 48.89% (22/45) in the control group; the difference was statistically significant (χ ²=12.80, P=0.000). The overall rate of improvement in cavitation absorption was 81.08% (30/37) in the observation group, compared with 54.29% (19/35) of the control group; the difference was statistically significant (χ ²=8.60, P=0.003). Nine months after the treatment, the rate of sputum negative conversion in the observation group was 91.11% (41/45), which was higher than 46.67% (21/45) of the control group; the difference was statistically significant (χ ²=20.74, P=0.000). The improvement rate was 75.56% (34/45) in the observation group and 44.44% (20/45) in the control group; the difference was statistically significant (χ ²=9.07, P=0.003). No serious adverse reactions occurred in the two groups during treatment. In conclusion, the clinical efficacy of local drug administration by bronchfiberscope combined with chemo-therapy in the treatment of multi-drug resistant pulmonary tuberculosis is superior to chemotherapy alone.

Key words: Tuberculosis, pulmonary, Multidrug-resistant, Bronchoscopy, Drug therapy, Comparative study