The role of IL-17 in immune response to tuberculosis

doi:10.3969/j.issn.2095-3755.2014.01.013

Abstract

Abstract: Along with the discovery of new CD4⁺ T-cell subsets has the concepts of immune response to tuberculosis renewed. T helper cell (Th) 17 that secretes interleukin (IL)-17, which is a novel subset of CD4⁺ T-cell different from Th1, Th2 and other regulatory t cells. It is found recently that there is a wide spectrum of Th17 phenotypes with differences in their cytokine production and effector functions. Early study suggests IL-17 and Th17 play critical roles in autoimmune diseases. Recent data suggest they play important roles in fighting Mycobacterium tuberculosis (Mtb) infection, but whether protective immunity or mediate immunopathology in response to Mtb infection is still controversial. In this review, we summarize the roles and the regulations of immune response of IL-17 and Th17 to tuberculosis. Understanding these mechanisms will enable us to develop specific immunotherapy against Mtb infection.

LI De-xian^*, ZHANG Tian-tuo, TAN Shou-yong. The role of IL-17 in immune response to tuberculosis[J]. Journal of Tuberculosis and Lung Health , 2014, 3(1): 60-63. doi: 10.3969/j.issn.2095-3755.2014.01.013

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