早期肺癌诊疗新进展

结核病与肺部健康杂志 ›› 2012, Vol. 1 ›› Issue (1): 22-26.

早期肺癌诊疗新进展

支修益

100053 北京,首都医科大学肺癌诊疗中心首都医科大学肿瘤学系首都医科大学宣武医院胸外科

收稿日期:2012-07-16 出版日期:2012-07-20 发布日期:2012-07-20

Progress of early lung cancer diagnosis and treatment

ZHI Xiu-yi

Lung Cancer Center & Department of Clinical Oncology, Capital Medical University; Department of Thoracic Surgery, Xuanwu Hospital, Beijing 100053,China

Received:2012-07-16 Online:2012-07-20 Published:2012-07-20

摘要/Abstract

摘要： 外科手术是早期肺癌治疗方式的首选。早期肺癌的标准手术方式是肺叶切除加淋巴结清扫。近年来以胸腔镜为代表的微创外科技术在临床广泛开展,胸腔镜肺叶切除的安全性已得到认可。近年来,随着医学影像技术的进步,临床发现了更多的早期肺癌,对于直径小于2cm的早期周围型肺癌,肺段切除或楔形切除能否取代肺叶切除成为此类型肺癌的标准手术方式,还有待于新的证据的出现。

Abstract: The surgery is the first choice for early lung cancer treatment. The standard approach is lobectomy plus lymph node dissection. In recent years, thoracoscopic minimally invasive surgical technique is widely carried out clinically; the safety of thoracoscopic lobectomy has been recognized. With the advances in medical imaging techno-logy, more cases of early lung cancer has been detected, for early peripheral lung cancer with the carcinoma less than 2cm in diameter, whether pulmonary segmentectomy or wedge resection could replace lobectomy as the standard operation of this type of lung cancer yet to the emergence of new evidence.

支修益. 早期肺癌诊疗新进展[J]. 结核病与肺部健康杂志, 2012, 1(1): 22-26.

ZHI Xiu-yi. Progress of early lung cancer diagnosis and treatment[J]. Journal of Tuberculosis and Lung Health, 2012, 1(1): 22-26.

参考文献

[1] Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin,2010,60(5):277-300.
[2] International Early Lung Cancer Action Program Investigators,Henschke CI,Yankelevitz DF,et al.Survival of patients with stage I lung cancer detected on CT screening. N Engl J Med,2006,355(17):1763-1771.
[3] Welch HG, Woloshin S, Schwartz LM, et al. Overstating the evidence for lung cancer screening: the International Early Lung Cancer Action Program (I-ELCAP) study.Arch Intern Med,2007,167(21):2289-2295.
[4] National Lung Screening Trial Research Team, Aberle DR, Adams AM,et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med,2011,365(5):395-409.
[5] Eberhardt R, Anantham D, Herth F, et al. Electromagnetic navigation diagnostic bronchoscopy in peripheral lung lesions. Chest, 2007,13l(6):1800-1805.
[6] Eberhardt R, Anantham D, Ernst A, et al. Multimodality bronchoscopic diagnosis of peripheral lung lesions:a randomized controlled trial. Am J Respir Crit Care Med, 2007,176(1):36-41.
[7] Silvestri GA, Gould MK, Margolis ML, et al. Noninvasive staging of non-small cell lung cancer: ACCP evidenced-based clinical practice guidelines (2nd edition). Chest,2007,132(3 Suppl):178S-201.
[8] Gould MK, Kuschner WG, Rydzak CE,et al.Test perfor-mance of positron emission tomography and computed tomography for mediastinal staging in patients with non-small-cell lung cancer: a meta-analysis. Ann Intern Med,2007,139(11):879-892.
[9] Yasufuku K, Nakajima T, Fujiwara T,et al. Role of endobronchial ultrasound-guided transbronchial needle aspiration in the management of lung cancer. Gen Thorac Cardiovsac Surg,2008,56(6):268-276.
[10] Lee HS,Lee GK,Lee HS,et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal staging of non-small cell lung cancer:how many aspirations per target lymph node station? Chest,2008,134(2):368-374.
[11] Hwangbo B,Kim SK,Lee HS,et al. Application of endobronchial ultrasound-guided transbronchial needle aspiration following integrated PET/CT in mediastinal staging of potentially operable non-small cell lung cancer. Chest,2009,135(5):1280-1287.
[12] Szlubowski A,Kuzdzal J,Kolodziej M,et al. Endobronchial ultrasound-guided needle aspiration in the non-small cell lung cancer staging. Eur J Cardiothorac Surg,2009,35(2):332-336.
[13] Detterbeck FC, Jantz MA, Wallace M,et al. Invasive mediastinal staging of lung cancer:ACCP evidence-based clinical practice guidelines (2nd edition). Chest,2007,132(3 Suppl):202S-220.
[14] Ettinger DS, Akerley W, Bepler G, et al. Non-small cell lung cancer. J Natl Compr Canc Netw,2008,6(3):228-269.
[15] LeBlanc JK,Devereaux BM,Imperiale TF,et al.Endoscopic ultrasound in non-small cell lung cancer and negative mediastinum on computed tomography.Am J Respir Crit Care Med,2005,171(2):177-182.
[16] Kirby TJ, Mack MJ, Landreneau RJ, et al. Initial experience with video-assisted thoracoscopic lobectomy. Ann Thorac Surg, 1993,56(6):1248-1253.
[17] McKenna RJ Jr,Houck W,Fuller CB.Video-assisted thoracic surgery lobectomy:experience with 1100 cases.Ann Thorac Surg,2006,81(2):421-426.
[18] Ginsberg RJ, Rubinstein LV. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg,1995,60(3):615-623.
[19] Koike T, Togashi K, Shirato T, et al. Limited resection for noninvasive bronchioloalveolar carcinoma diagnosed by intraoperative pathologic examination. Ann Thorac Surg,2009,88(4):1106-1111.
[20] Higaki F,Okumura Y,Sato S,et al.Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor. Ann Nucl Med,2008,22(3):157-163.
[21] Zhu JC,Yan TD,Morris DL.A systematic review of radiofrequency ablation for lung tumors. Ann Surg Oncol, 2008,15(6):1765-1774.
[22] Lencioni R,Crocetti L,Cioni R,et al.Response to radiofrequency ablation of pulmonary tumors:a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study).Lancet Oncol, 2008,9(7):621-628.
[23] Dupuy DE, DiPetrillo T, Gandhi S, et al. Radiofrequency ablation followed by conventional radiotherapy for medically inoperable stage Ⅰ non-small cell lung cancer. Chest,2006,129(3):738-745.
[24] Naruke T. Significance of lymph node metastases in lung can-cer. Semin Thorac Cardiovasc Surg,1993,5(3):210-218.