Abstract: Objective To investigate epidemiological association of HIV (human immunodeficiency virus) and tuberculosis (TB) dual infection patients in Wenshan Zhuang and Miao Autonomous Prefecture (Wenshan Prefecture) and provide scientific basis for the development of HIV/TB dual infection prevention and control countermeasures.Methods We collected the TB patients information screened from 6230 cases of HIV/AIDS patients,and HIV/AIDS patients patients screened from 6430 cases of TB patients between 2007 and 2012 in Wenshan Prefecture. Then make a descriptive analysis.Results After screening, we detected a total of 382 cases of TB/HIV dual infection patients,and active tuberculosis detection rate in HIV/AIDS patients is 5.01% (312/6230) and HIV infection rate in TB patients is 1.09% (70/6430).Conclusion The co-infection epidemic is serious in Wenshan Prefecture. Therefore, AIDS prevention should be an important work of TB control in the future, Examination and treatment of tuberculosis should become an important area in fighting against AIDS.