Abstract: Objective To analyze the clinical characteristics of patients with nasopharyngeal tuberculosis.Methods A retrospective analysis was made on clinical manifestations, test results, misdiagnosis, treatment and outcome of 15 cases of biopsy confirmed nasopharyngeal tuberculosis registered in Wuhan Medical Care Center from 2003 to 2012.Results Two cases of 15 showed low fever and night sweat. Six cases showed enlargement of neck lymph nodes, among them, two showed initial neck mass. Fourteen cases had purified protein derivative tuberculin (PPD) positive result, 10 strong positive and 1 negative. One case had Mycobactcrium tuberculosis sputum culture positive result and 14 were negative. Thirteen cases of 15 had different degrees of misdiagnosis, 10 cases were misdiagnosed as nasopharyngeal carcinoma, 2 cases were misdiagnosed as nasopharyngitis, 1 case were misdiagnosed as sleep apnea hypopnea syndrome (SAHS). Through the standard and systematic anti-tuberculosis treatment, the clinical symptoms of all patients were relieved.Conclusion The clinical manifestation of nasopharyngeal tuberculosis is untypical and it is easily misdiagnosed.Doctors should raise awareness of nasopharyngeal tuberculosis and do pathological examination early and repeatedly for early treatment.