非结核分枝杆菌相关研究新进展

doi:10.3969/j.issn.2095-3755.2015.01.014

摘要/Abstract

摘要： 非结核分枝杆菌在自然界中广泛存在,部分可引起人类疾病。因非结核分枝杆菌对多种抗结核药物耐药,且诊断困难、患者预后较差,使非结核分枝杆菌感染性疾病逐渐成为医学界十分关注的研究课题。作者从非结核分枝杆菌种类及感染率、非结核分枝杆菌耐药情况及耐药机制研究、非结核分枝杆菌感染特点及治疗方案、非结核分枝杆菌检测方法及环境水非结核分枝杆菌污染研究等方面综述了非结核分枝杆菌相关的研究进展。其耐药机制及传播机制尚未阐明,需要进行深入研究。

Abstract: Nontuberculous mycobacteria exist in nature widely, but only some of them cause diseases in human. As some nontuberculous mycobacteria are resistant to some anti-tuberculosis drugs, and it is difficult to diagnose and with poor treatment outcome, the nontuberculous mycobacterial infectious diseases have become the concerned research topic in medical field gradually. This article reviewed the progress of study on nontuberculous mycobacteria by summarizing the species and infection rate, drug resistance mechanisms and detection methods, the cha-racteristics of nontuberculous mycobacterial infection and treatment regimens, and the research on water pollution of nontuberculous mycobacterial. The drug-resistance and transmission mechanisms of nontuberculous mycobacteria have not been elucidated, further research is needed.

王春花,庞学文,傅衍勇. 非结核分枝杆菌相关研究新进展[J]. 结核病与肺部健康杂志, 2015, 4(1): 61-64. doi: 10.3969/j.issn.2095-3755.2015.01.014

WANG Chun-hua, PANG Xue-wen, FU Yan-yong. Research progresses of nontuberculous mycobacteria[J]. Journal of Tuberculosis and Lung Health, 2015, 4(1): 61-64. doi: 10.3969/j.issn.2095-3755.2015.01.014

参考文献

[1] Falkinham JO 3rd. Nontuberculous mycobacteria in the environment. Clin Chest Med,2002,23(3):529-551.
[2] 张贺秋,赵雁林.现代结核病诊断技术. 北京:人民卫生出版社,2013.
[3] von Reyn CF, Arbeit RD, Horsburgh CR, et al. Sources of disseminated Mycobacterium avium infection in AIDS. J Infect, 2002,44(3):166-170.
[4] 梅建.非结核分枝杆菌与非结核分枝杆菌病.澳门医学杂志,2001, 1(3):245-252.
[5] 全国结核病流行病学抽样调查技术指导组,全国结核病流行病学抽样调查办公室.2000年全国结核病流行病学抽样调查资料汇编.北京:人民卫生出版社, 2003:60-65.
[6] 全国第五次结核病流行病学抽样调查技术指导组,全国第五次结核病流行病学抽样调查办公室. 2010年全国第五次结核病流行病学抽样调查报告. 中国防痨杂志, 2012,34(8): 485-508.
[7] Herdman AV, Steele JC Jr. The new mycobacterial species—emerging or newly distinguished pathogens. Clin Lab Med, 2004,24(3):651-690.
[8] Ngan GJ,Ng LM,Jureen R,et al. Development of multiplex PCR assays based on the 16S-23S rRNA internal transcribed spacer for the detection of clinically relevant nontuberculous mycobacteria.Lett Appl Microbiol,2011,52(5):546-554.
[9] Shojaei H,Heidarieh P,Hashemi A,et al.Species identification of neglected nontuberculous mycobacteria in a developing country.Jpn J Infect Dis,2011,64(4):265-271.
[10] 李艳冰,张媛媛,黄明翔,等.hsp65和rpoB PCR-RFLP用于龟/脓肿分枝杆菌复合群种的快速鉴定.中国人畜共患病学报,2012,28(7):645-652.
[11] 王桂荣,付育红,梁倩,等.应用多重PCR方法快速鉴定结核分枝杆菌复合群与非结核分枝杆菌的研究. 中国防痨杂志,2013,35(9):686-689.
[12] 林世平,林一曼,石晓路,等.非结核分枝杆菌耐药性特征及聚合酶链式反应检测方法的建立.热带医学杂志,2014,14(3):304-307.
[13] 李国利,赵铭,张灵霞,等.免疫层析法检测MPT64蛋白在结核与非结核分枝杆菌鉴定中的临床应用价值.中国医药导报,2012, 9(31):152-153.
[14] 白广红,李耀军,焦向阳.胶体金法快速检测结核分枝杆菌和非结核分枝杆菌的研究.国际检验医学杂志,2013,34(10):1274-1276.
[15] 卢峰岳,黄艳君,刘春平,等.γ-干扰素释放试验诊断活动性结核病的临床评价. 实用医学杂志,2013,29(23):3827-3829.
[16] 王爱平,涂平,陈伟,等.皮肤非结核分枝杆菌感染三例.实用皮肤病学杂志, 2014, 7(1):7-9.
[17] 陈兴年,叶志坚,吴妹英. 非结核分枝杆菌肺病血清中细胞因子的检测及临床意义. 临床肺科杂志,2014,19(3):499-504.
[18] Brown-Elliott BA, Nash KA, Wallace RJ Jr. Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria. Clin Microbiol Rev, 2012, 25(3):545-582.
[19] 吴龙章,陈素颖,曾少芳,等.广州市12年间分枝杆菌菌型与药物敏感性结果变迁的分析.中华预防医学杂志,2011,45(1):26-29.
[20] 吴龙章,谭守勇,谭耀驹,等. 1819株非结核分枝杆菌行药物敏感性试验的结果分析.中国防痨杂志,2012,34(12):821-824.
[21] 陈华,陈品儒,苏铎华,等.非结核分枝杆菌分布特点与耐药性分析.中华医院感染学杂志,2012,22(23):5419-5421.
[22] 邹远妩,周祎,高漫,等.54 例非结核分枝杆菌感染者对二线抗结核药的耐药分析.中华实验和临床感染病杂志(电子版), 2014,8(1):36-38.
[23] Hernández-Garduo E, Elwood RK. Demographic risk factors of pulmonary colonization by non-tuberculous mycobacteia. Int J Tuberc Lung Dis,2010,14(1):106-112.
[24] Silva PE, Bigi F, Santangelo MP,et a1.Characterization of P55,a multidrug efflux pump in Mycobacterium bovis and Mycobacterium tuberculosis.Antimicrob Agents Chemother,2001, 45(3):800-804.
[25] Li XZ, Zhang L, Nikaido H. Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Antimicrob Agents Chemother,2004,48(7):2415-2423.
[26] De Rossi E,Arrigo P,Bellinzoni M, et a1. The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.Mol Med,2002,8(11):714-724.
[27] Diagnosis and treatment of disease caused by nontuberculous mycobacteria. This official statement of the American Thora-cic Society was approved by the Board of Directors, March 1997. Medical Section of the American Lung Association. Am J Respir Crit Care Med, 1997, 156(2 Pt 2):S1-25.
[28] Latshang TD,Lo Cascio CM,Russi EW.Nontuberculous mycobacterial infections of the lung [Article in German].Ther Umsch,2011,68(7):402-406.
[29] Cox R, deBorja K, Bach MC.A pseudo-outbreak of Mycobaterium chelonae infections related to bronchoscopy. Infect Control Hosp Eopidemiol, 1997,18(2):136-137.
[30] 吴晓光,高孟秋,马丽萍.非结核分枝杆菌病50例临床分析.中国防痨杂志,2009,31(8):481-483.
[31] Griffith DE, Aksamit T, Brown-Elliott BA, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med, 2007, 175(4):367-416.
[32] 周昌明,蓝如束,廖光付,等.291 例 HIV/AIDS 患者合并分枝杆菌感染情况分析. 广西医学,2013,35(1):29-31.
[33] 刘雅琼,林辉,于磊,等.类获得性免疫缺陷(阴性 HIV)“患者”的流行病学调查.第三军医大学学报, 2013,35(5): 369-375.
[34] 鲍容,胡必杰,周昭彦,等.ICU自来水非结核分枝杆菌污染状况调查.中华医院感染学杂志,2013,23(8):1858-1862.
[35] 郭军,徐国纲,周长喜,等.老年机械通气患者非结核分枝杆菌肺病的临床分析(附4例报告).北京医学,2014,36(3):180-183.
[36] 陈超,徐鹏,李静,等.城市生活饮用水中非结核分枝杆菌调查.微生物与感染,2008,3(4):215-218.
[37] Crago B, Ferrato C, Drews SJ, et al.Surveillance and molecular characterization of non-tuberculous mycobacteria in a hospital water distribution system over a three-year period. J Hosp Infect, 2014,87(1):59-62.
[38] Velayati AA, Farnia P, Mozafari M, et al.Molecular epidemiology of nontuberculous mycobacteria isolates from clinical and environmental sources of a metropolitan city. PLoS One,2014,9(12):e114428.