Abstract: Objective To analyze the anti-tuberculosis adverse drug reactions (ADRs) occurred in the patients with pulmonary tuberculosis (PTB) in Yancheng city in 2012. Methods When timely treating the anti-tuberculosis ADRs in 3842 cases of PTB patients, all institutions of tuberculosis prevention and control in Yancheng city should fill in the case table of the anti-tuberculosis ADRs,which mainly included sex,age,ADRs occurrence date,duration,severity,type,laboratory examination,measures and results, treatment outcome, and so on. And then we carried on statistical analysis. Results A total of 94 cases of the anti-tuberculosis drugs ADRs were occurred and reported. The incidence rate was 2.45%(94/3842).Male and female were 66 and 28 cases respectively. The rate was 2.4∶1.This study has following findings. First, in terms of the ADRs rate, less than 20,20-29,30-39,40-49,50-59,60-69 and 70-95 age groups were 1.64%(2/122),2.14%(11/513),2.82%(9/319),3.06％(17/556),2.94%(22/748),2.28%(19/835),1.87%(14/749)respectively. The ADRs of male and female incidence were 2.38% (66/2772) and 2.62% (28/1070).There was no statistically significant difference (χ²＝0.1800,P>0.05).The peak of male and female were in 50-59 (3.06%;17/556) and 30-39 (3.60%;4/111) age group respectively. Second, liver damage rate was 72.34% (68/94).Hepatic injury complicated with gastrointestinal reactions accounted for 31.91% (30/94). Two or more ADRs accounted for 40.43% (38/94).Third, the mean times of occurrence and duration were (35.4±28.7)d,(21.2±21.0)d. There were 87.23% (82/94)and 50.00% (47/94)of ADRs occurred within 60 days and 30 days respectively. There was 87.50% (7/8) of simple allergic reaction occurred within 10 days. There was 72.72% (8/11) of simple gastrointestinal reaction occurred within 20 days. There were 28.57% (10/35), 88.57% (31/35) of simple liver damage occurred within 30 days and 60 days respectively. Forth, there were 93.62% (88/94) of ADRs cured or completed treatment and 63.83% (60/94) of ADRs changed treatment or medication way. Conclusion The anti-tuberculosis ADRs in Yancheng city was in the low level. The liver damage, which often occurred with gastrointestinal reaction, was in a majority. The incidence rate of the ADRs was higher in 30-59 age group. The peak age group of male was higher than female.