苏州市结核病链霉素耐药情况分析

doi:10.3969/j.issn.2095-3755.2013.04.016

结核病与肺部健康杂志 ›› 2013, Vol. 2 ›› Issue (4): 292-295.doi: 10.3969/j.issn.2095-3755.2013.04.016

苏州市结核病链霉素耐药情况分析

叶志坚,唐佩军,施美华,沈兴华,吴妹英,肖玉梅

215007 苏州市第五人民医院呼吸科

收稿日期:2013-04-24 出版日期:2013-11-30 发布日期:2013-11-30
通信作者: 肖玉梅,Email:liaohua1963@126.com
基金资助:
苏州市科技支撑计划(SS201241);苏州市科技发展项目(SWKQ0824)

Analysis of streptomycin resistance of Mycobacterium tuberculosis situation in Suzhou city

YE Zhi-jian, TANG Pei-jun, SHI Mei-hua, SHEN Xing-hua, WU Mei-ying, XIAO Yu-mei

Department of Respiration, Fifth Hospital,Soochow University, Suzhou 215007, China

Received:2013-04-24 Online:2013-11-30 Published:2013-11-30
Contact: XIAO Yu-mei,Email:liaohua1963@126.com

摘要/Abstract

摘要： 目的了解苏州市肺结核(pulmonary tuberculosis, PTB)患者对抗结核药物链霉素的耐药情况。方法回顾性分析2008年9月至2011年5月的苏州市肺结核患者1749例对链霉素的耐药情况,以及其与异烟肼、利福平和乙胺丁醇耐药组合及其在耐多药结核病中的构成情况,并对各组构成率采用卡方检验进行统计学分析,P<0.05为差异有统计学意义。结果苏州市近3年间结核病患者对链霉素的总体耐药率为24.7%(432/1749),其在耐多药患者中的比率为87.4%(160/183);复治患者对链霉素的耐药率为44.3%(160/361),明显高于初治患者19.6％(272/1388),差异有显著统计学意义(χ²=94.16,P<0.01);并且复治患者较初治患者对链霉素耐药占耐多药患者中的比率[分别为93.5％(87/93)、81.1％(73/90)]差异也有统计学意义(χ²=6.44,P<0.05)。结论苏州市结核病患者的单药耐药率链霉素最高,且对链霉素的耐药率在耐多药初治结核病患者和复治患者中所占比例均较高。

Abstract: Objective To investigate the streptomycin resistance of anti-TB drugs in patients with pulmonary tuberculosis (PTB) in Suzhou city. Methods Retrospectively analysis were carried out on the 1749 patients with PTB of Suzhou city between September 2008 and May 2011 to investigate the streptomycin-resistance rate and the incidence of resistance rate of streptomycin combination with isoniazid, rifampicin or ethambutol and the streptomycin resistance rate’s composition in the multidrug-resistant TB(MDR-TB). The Chi-square test was used for statistical analysis, P<0.05 is considered statistically significant. Results In recent 3 years in Suzhou city, the total streptomycin-resistance rate was 24.7%(432/1749) and 87.4%(160/183) of MDR-TB cases were streptomycin-resistant. The streptomycin-resistance rate in retreatment cases was 44.3%(160/361), which is significantly higher than 19.6%(272/1388) in new cases (χ²=94.16,P<0.01). 93.5％(87/93)of patients in retreatment cases were streptomycin-resistant, which is also significantly higher than 81.1％(73/90)in new cases (χ²=6.44,P<0.05). Conclusion The streptomycin-resistance rate had highest single drug resistance in patients with PTB in Suzhou city, and streptomycin-resistance rate were high both in new and retreatment of MDR-TB patients.

叶志坚,唐佩军,施美华,沈兴华,吴妹英,肖玉梅. 苏州市结核病链霉素耐药情况分析[J]. 结核病与肺部健康杂志, 2013, 2(4): 292-295. doi: 10.3969/j.issn.2095-3755.2013.04.016

YE Zhi-jian, TANG Pei-jun, SHI Mei-hua, SHEN Xing-hua, WU Mei-ying, XIAO Yu-mei. Analysis of streptomycin resistance of Mycobacterium tuberculosis situation in Suzhou city[J]. Journal of Tuberculosis and Lung Health, 2013, 2(4): 292-295. doi: 10.3969/j.issn.2095-3755.2013.04.016

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苏州市结核病链霉素耐药情况分析

Analysis of streptomycin resistance of Mycobacterium tuberculosis situation in Suzhou city

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