Abstract: Objective To probe the mechanism of the tuberculosis wound repairing, through detect the Epidermal growth factor( EGF) and Basic fibroblast growth factor (bFGF ) in the wound fluid, compare those contents in the normal infected wound, to direct clinical practice. Methods Respectively, we divide 30 cases of tuberculosis wound & 30 cases of normal infected wound in experimental group & comparison group. We collect the wound fluid, detect the contents of EGF、bFGF, and record the entire heal time. We use the t-test and Pearson relation test process the data. Results The contents of EGF、bFGF in the experimental group in the 7d（ng/ml）: 0.200±0.019 ；0.021±0.003 evidently less than the control group in the 7d（ng/ml）:0.533 ± 0.023；0.069±0.003 (t＝6.725,P<0.05；t＝5.783，P<0.05) ; During the experimental group the contents of EGF 、bFGF in the late stage the 42d（ng/ml）：0.300±0.018,0.062±0.003, are much more than those in the early stage the 7d（ng/ml）： 0.200±0.019,0.021±0.003,（t’＝0.813， P＝0.015）(t’＝0.655，P＝0.110). The average heal time of between the two groups is （133.170±81.390）d and （21.000±1.900）d（t＝8.414，P＜0.05）, it has statistical difference. Conclusion There are less EGF、bFGF in the tuberculosis wound micro-environment. It’s the important reason of the delay healing of wound, adjust the contents of EGF、bFGF can improve the healing of wound.