Respiratory manifestation and imageology in patient with hemophagocytic lymphohistiocytosis

Abstract

Abstract: Objective Hemophagocytic lymphohistiocytosis(HLH)is a nonmalignant disorder of immune re-gulation,with nonspecific symptoms and multiple organs affected. Aim of our study is to investigate the clinical and imaging charateristics of respiratory system in HLH patients so as to help to improve the early diagnosis of HLH.Methods Clinical features and radiological manifestations of confirmed HLH patients in Ruijin Hospital since 2006 were retrospectively reviewed.Results Eleven cases of HLH were enrolled in our study,whose major signs and symptoms of respiratory system are cough,dyspnea and tachypnea. Ground-glass opacities(2 cases)and nodular lesion(3 cases)were the main features of chest radiographs(3 cases totally),meanwhile ground-glass opacities(3 cases),mediastinal lymphadenectasis(5 cases),pleural effusion(7 cases)and pleural thickening(6 cases)were also the main features of chest CT(8 cases totally).Conclusion Although both clinical features and radiological changes of respiratory system are nonspecific,respiratory failure and diffused ground-glass opacity are recognized as important features in severe HLH.

TAO Lian-qin,WANG Yi-jia,SHI Guo-chao. Respiratory manifestation and imageology in patient with hemophagocytic lymphohistiocytosis[J]. Journal of Tuberculosis and Lung Health , 2013, 2(2): 86-91.

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