Progress in diagnosis and treatment of bronchial asthma

Abstract

Abstract: In recent year, with the development of the etiology and pathogenesis of bronchial asthma, its diagnosis and treatment has made great progress. New diagnostic examinations emerged including analysis of exhaled NO and exhaled breath condensate component, airway remodelling imaging evaluation and phenotypic analysis. New treatment technologies developed including bronchial thermoplasty, the application of inflammatory mediators’ antagonists, sublingual specific immunotherapy, as well as vitamin D, anti-fungal therapy and the application of proton pump inhibitors. These developments in diagnosis and treatment provide more choices for asthma prevention and control.

SHI Guo-chao, WANG Lin-lin. Progress in diagnosis and treatment of bronchial asthma[J]. Journal of Tuberculosis and Lung Health , 2012, 1(1): 27-31.

References

[1] Taylor DR, Pavord ID. Biomarkers in the assessment and management of airways diseases. Postgrad Med J, 2008, 84(998):628-634.
[2] Jrres RA. Modelling the production of nitric oxide within the human airways.Eur Respir J, 2000, 16 (3):555-560.
[3] Barnes PJ, Dweik RA, Gelb AF, et al. Exhaled nitric oxide in pulmonary diseases: a comprehensive review. Chest, 2010, 138(3):682-692.
[4] Smith AD, Cowan JO, Brassett KP, et al. Exhaled nitric oxide: a predictor of steroid response. Am J Respir Crit Care Med, 2005, 172 (4): 453-459.
[5] Zacharasiewicz A, Wilson N, Lex C, et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med, 2005, 171 (10): 1077-1082.
[6] Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med,2011, 184(5):602-615.
[7] Kostikas K, Papaioannou AI, Tanou K, et al. Exhaled NO and exhaled breath condensate pH in the evaluation of asthma control. Respir Med, 2011, 105(4):526-532.
[8] Murugan A, Prys-Picard C, Calhoun WJ. Biomarkers in asthma. Curr Opin Pulm Med, 2009, 15(1):12-18.
[9] Caballero Balanzá S,Martorell Aragonés A,Cerdá Mir JC, et al. Leukotriene B4 and 8-isoprostane in exhaled breath condensate of children with episodic and persistent asthma. J Investig Allergol Clin Immunol, 2010, 20(3):237-243.
[10] Teng Y, Sun P, Zhang J, et al. Hydrogen peroxide in exhaled breath condensate in patients with asthma: a promising biomarker? Chest, 2011, 140(1):108-116.
[11] Gupta S, Siddiqui S, Haldar P, et al. Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax,2010, 65(9):775-781.
[12] Gupta S, Siddiqui S, Haldar P, et al. Qualitative analysis of high-resolution CT scans in severe asthma. Chest, 2009, 136(6):1521-1528.
[13] Brillet PY, Attali V, Nachbaur G, et al. Multidetector row computed tomography to assess changes in airways linked to asthma control. Respiration, 2011, 81(6):461-468.
[14] Soja J, Grzanka P, Sladek K, et al. The use of endobronchial ultrasonography in assessment of bronchial wall remodeling in patients with asthma. Chest, 2009, 136(3):797-804.
[15] Fahy JV. Identifying clinical phenotypes of asthma: steps in the right direction. Am J Respir Crit Care Med, 2010, 181(4):296-297.
[16] Cowan DC, Cowan JO, Palmay R, et al. Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax, 2010, 65(5):384-390.
[17] Woodruff PG, Modrek B, Choy DF,et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med, 2009, 180(5):388-395.
[18] Gentile DA, Skoner DP. New asthma drugs: small molecule inhaled corticosteroids. Curr Opin Pharmacol, 2010, 10(3):260-265.
[19] Vogelmeier CF, Hering T, Lewin T, et al. Efficacy and safety of ciclesonide in the treatment of 24 037 asthmatic patients in routine medical care. Respir Med, 2011, 105(2):186-194.
[20] Peters SP, Kunselman SJ, Icitovic N, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med, 2010, 363(18):1715-1726.
[21] Novembre E, Galli E, Landi F, et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol, 2004, 114(4):851-857.
[22] Calamita Z, Saconato H, Pelá AB, et al. Efficacy of sublingual immunotherapy in asthma: systematic review of rando-mized-clinical trials using the Cochrane Collaboration method. Allergy, 2006, 61(10):1162-1172.
[23] Marogna M, Spadolini I, Massolo A, et al. Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study. J Allergy Clin Immunol, 2010, 126(5):969-975.
[24] Spector S. Omalizumab:efficacy in allergic disease. Panminerva Med, 2004, 46(2):141-148.
[25] Holgate S, Casale T, Wenzel S, et al. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. J Allergy Clin Immunol, 2005, 115(3): 459-465.
[26] Costello RW, Long DA, Gaine S, et al. Therapy with omalizumab for patients with severe allergic asthma improves asthma control and reduces overall healthcare costs. Ir J Med Sci, 2011, 180(3):637-641.
[27] Castro M, Mathur S, Hargreave F, et al. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med, 2011, 184(10):1125-1132.
[28] Gauvreau GM, Boulet LP, Cockcroft DW, et al. Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. Am J Respir Crit Care Med, 2011, 183(8):1007-1014.
[29] Corren J, Busse W, Meltzer EO, et al. A randomized, controlled, phase 2 study of AMG 317, an IL-4 Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med, 2010, 181(8):788-796.
[30] Castro M, Rubin A, Laviolette M, et al. Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma. Ann Allergy Asthma Immunol,2011, 107(1):65-70.
[31] Castro M, Rubin AS, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med,2010, 181(2):116-124.
[32] Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol, 2010, 105(3):191-199.
[33] Hollams EM, Hart PH, Holt BJ, et al. Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study. Eur Respir J, 2011, 38(6):1320-1327.
[34] Denning DW, O’Driscoll BR, Powell G, et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization:The Fungal Asthma Sensitization Trial (FAST) Study. Am J Respir Crit Care Med, 2009, 179(1):11-18.
[35] Cheung TK, Lam B, Lam KF, et al. Gastroesophageal reflux disease is associated with poor asthma control, quality of life, and psychological status in Chinese asthma patients. Chest,2009,135(5):1181-1185.