Abstract: Objective To study the adverse reactions of 1200 children aged between 6-15 years old on rifapentine (L) and isoniazid (H) for TB preventive treatment.Methods A total of 1200 cases of children aged 6-15 at Xinmi from 2012—2014, whose tuberculin test were strongly positive, were selected. To observe the adverse reaction through the blood and liver function tests before and 1, 2 and 3 months after the treatment onset.Results (1) The adverse reaction incidence rate was 7.0% (84/120) in the first month, for boys and girls respectively 7.2% (44/614) and 6.8% (40/586), no significant difference (χ²=0.05, P>0.05). Among them 1.2% (14/1200) of gastrointestinal reactions, 2.8% (33/1200) of hepatic dysfunction, 3.1% (37/1200) of decreased white blood cell. (2) The adverse reaction incidence rate was 7.1% (34/482) in the second month, for boys and girls respectively 7.5% (19/254) and 6.6% (15/228), no significant difference (χ²=0.15, P>0.05). Among them 0.6% (3/482) of gastrointestinal reactions, 2.5% (12/482) of hepatic dysfunction, 3.9% (19/482) of decreased white blood cell. (3) The adverse reaction incidence rate was 6.2% (27/439) in the third month, for boys and girls respectively 7.2% (16/228) and 5.2％ (11/211), no significant difference (χ²=0.62, P>0.05). Among them 1.4% (6/439) of hepatic dysfunction, 4.8% (21/439) of decreased white blood cell. (4) The average monthly incidence of adverse reactions was 6.8％ (145/2121), 7.2% (79/1096) and 6.4% (66/1025) respectively for boys and girls, no significant difference (χ²=0.49, P>0.05). (5) Adverse reaction incidence in children aged 6－15 years old in turn was 11.6% (13/112), 9.1% (17/187), 7.2% (11/152), 5.4% (7/129), 6.7% (8/119), 3.3% (3/92), 7.1% (10/141), 7.1% (8/112), 5.7% (3/53) and 3.9% (4/103) respectively, there was no statistically significant difference in the incidence of adverse reactions by age (χ²=7.86, P>0.05).Conclusion The adverse reaction incidence rate of L+H regimen for preventive treatment for children aged between 6－15 years old are in normal level, but we need to perform periodic liver function and blood test during treatment so as to avoid severe reaction.