Abstract: Objective We summarized the treatment experience of spontaneous pneumothorax (SP) in patients diagnosed with TB.Methods We retrospectively collected and analyzed the medical records of 49 patients with TB and secondary SP treated in our hospital between July, 2008 and July, 2013.Results During the study period, a total of 850 patients with SP were treated in our hospital, 49 of whom had SP secondary to TB. Also during this period, 2179 cases of active TB were treated. Of the 49 cases with secondary SP, 21 presented with active TB at the moment of producing SSP and 28 had inactive TB. With regard to pleural drainage (PD) as a treatment for SSP, forty one (83.7%) patients needed one PD, four (8.1%) needed two, and two (4.1%) needed three. A decision to wait was made in two patients (4.1%), and the evolution of their SSP was favourable during their stay. The mean stay for PD was (12.5±11.1) days. The treatment for these recurrences was to perform another PD in 6 (18.3%) cases, 1 (4.1%)of them occurred contra laterally, and 5 (8.1%)patients needed surgery. VATS was performed in 14 (28.6%) patients for persistent air leakage after PD and relapses, There were 3 (21.4%) posto-perative complications: persistent air leaks for >5 days in 1 case, pneumonia in 1 case and surgical wound infection in 1. The hospital length of stay was (15.02±13.07) days.Conclusion The treatment of SP secondary to TB with PD is usually a sound response, with a good general prognosis and a low percentage of cases that require another PD and surgical treatment.