Abstract: Objective To study the influence of family support on treatment compliance and cure rate of MDR-TB patients. Methods A total of 44 MDR-TB patients were registered who finished the full course treatment in the Guangzhou Chest-Disease Hospital from Jan. 2010 to Jun. 2013. The patients were interviewed by the self-designed questionnaires and the relationship between family support,treatment compliance and cure rate were analyzed. All questionnaires were returned. At same time, we analyzed treatment compliance and cure rate between different family support by Chi-square statistics test, P<0.05 was considered statistically significant. Results The family support can improve the MDR-TB patients’ treatment compliance and cure rate. patients with good family support had good treatment compliance(90.9%,30/33) and cure rate (81.8%,27/33). But the treatment comp-liance and cure rate were 54.5%(6/11) and 45.5% (5/11)respectively in patients with low family support. The two groups were significantly different in treatment compliance and cure rate (corrected χ²=5.09, 3.82, P<0.05). Conclusion The family support is very important to the treatment results of MDR-TB patients. We should pay attention to the health education for MDR-TB cases’ family members and ensure the patients to get the high quality family support.