Abstract: Objective To investigate the mental health status of floating population with tuberculosis in order to provide evidence-based psychological treatment and health education.Methods We investigated the mental health status of 173 cases of floating population with tuberculosis by the symptom checklist (SCL-90), and made comparison with 1388 cases of national norm. EpiData 3.0 software is used for setting up the database and data entry. PASW 18.0 is used for statistical analysis.Results SCL-90 shows the experimental group has lower scores in somatic(score 1.24±0.36), compulsive (score 1.40±0.36), depressed (score 1.36±0.33) and psychotic symptoms factor (1.15±0.26) compared to the domestic norm(scores respectively 1.37±0.48, 1.62±0.52, 1.50±0.59, 1.29±0.42). The differences are statistically significant (t values is －5.20, －8.71, －5.95, －7.83, P<0.01). Score in interpersonal sensitivity, anxiety, and hostile factor (respectively 1.71±0.48, 1.57±0.54, 1.56±0.54) is higher than domestic norm(respectively 1.65±0.61, 1.39±0.43, 1.46±0.55). The differences are statistically significant (t values is 2.24, 4.58, 2.73, P<0.01). By using multivariate analysis, we find that interpersonal sensitivity is related to annual income, patient category and with or without lung cavity (patients with annual incomes between 5000 to 10000 yuan, Wald χ²=20.916,P<0.001,OR=0.035,95%CI:0.008-0.147; patients with annual incomes of between 10000 to 15000 yuan, Wald χ²=1.146,P=0.284,OR=0.393,95%CI＝0.071-2.171; patients with annual incomes of 15000 to 20000 yuan, Wald χ²=0.317,P=0.573,OR=0.731,95%CI＝0.246-2.174; patients with annual incomes of more than 20000 yuan, Wald χ²=6.145,P=0.013,OR=0.247,95%CI＝0.081-0.746; for previously treated patients, Wald χ²=4.321,P=0.038,OR=0.248,95%CI＝0.067-0.924; for patients with lung cavities, Wald χ²=4.123,P=0.042,OR=2.321,95%CI＝1.030-5.232). The anxiety factor is related to annual income (annual income between 5000-10000 yuan, Wald χ²=14.047, P<0.001, OR=0.016,95%CI: 0.002-0.130; annual income of 15000-20000 yuan, Wald χ²=1.650, P=0.199, OR=2.083,95%CI＝0.680-6.370; annual income of more than 20000 yuan, Wald χ²=4.934, P=0.026, OR=0.253,95%CI＝0.075-0.850).Conclusion Migrant patients’ mental health status is relevant to patients’ illness condition, patient category and annual income. In general, the mental health status of floating population with tuberculosis is relatively low. Therefore, mental therapy should be provided.