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Journal of Tuberculosis and Lung Disease ›› 2023, Vol. 4 ›› Issue (2): 98-109.doi: 10.19983/j.issn.2096-8493.20230025

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Structure, substrate and function of mycobacterium type Ⅶ secretory system

Jiang Zhiyong, Xie Jianping()   

  1. Institute of Modern Biology and Medicine, School of Life Sciences, Southwest University, Chongqing 400715, China
  • Received:2023-02-04 Online:2023-04-20 Published:2023-04-07
  • Contact: Xie Jianping, Email:


Bacterial secretion system is very important for bacterial development, intraspecific and interspecific competition, nutrition acquisition, virulence, physiology, genetics and ecology. Bacteria use the secretion system to secrete proteins outside the cell, which is also necessary for bacteria to adapt to the environment. Mycobacterium type Ⅶ secretory system and its substrate are closely related to the pathogenesis of Mycobacterium tuberculosis. This article introduces the composition, structure, substrate and function of type Ⅶ secretion system, especially its function in interaction with host, hoping to provide a basis for the research and development of new control measures for tuberculosis.

Key words: Mycobacterium, Ⅶ Secretory system, Bacterial proteins

CLC Number: