Research progress of chronic myeloid leukemia complicated with tuberculosis

doi:10.19983/j.issn.2096-8493.20220108

Abstract

Abstract:

Chronic myeloid leukemia is the first hematological malignancy found to be associated with genetic alterations. It can be functionally cured by targeted therapy with tyrosine kinase inhibitors. However, there are some problems that limit the treatment, and tuberculosis is one of the important factors. Anti-tuberculosis drugs can affect the pharmacokinetics of other drugs by altering the metabolism of liver enzymes and challenge the targeted treatment of chronic myeloid leukemia drugs. In the future, further research and special randomized controlled trials are still needed to formulate more clear and sufficient treatment guidelines, to improve the therapeutic efficacy of such patients.

Key words: Leukemia, myelogenous, chronic, Tuberculosis, Comorbidity, Pharmacokinetics

CLC Number:

R551
R52

Liu Yukun, Guo Zhi. Research progress of chronic myeloid leukemia complicated with tuberculosis[J]. Journal of Tuberculosis and Lung Disease , 2022, 3(4): 325-327. doi: 10.19983/j.issn.2096-8493.20220108

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