Research progress of desensitization therapy and cutaneous adverse drug reactions induced by rifampicin and isoniazid

doi:10.3969/j.issn.2095-3755.2018.04.019

Abstract

Abstract:

Rifampicin and isoniazid, as the core drugs for the treatment of tuberculosis, can cause delayed allergic reactions, even severe adverse reactions such as Stevens-Johnson syndrome (SJS), drug-induced hypersensitivity syndrome (DIHS) and other severe allergic systemic symptoms, threatening the life safety of patients. Identification of allergenic drugs and implementation of desensitization therapy have become the key to safe and effective anti-tuberculosis therapy. In this article, we made a comprehensive literature review, and analyzed and summarized the sensitizing mechanisms of rifampicin and isoniazid in skin anaphylaxis, the common clinical manifestations, the detection of sensitizing drugs and the desensitization therapeutic scheme, so as to provide references for the desensitization treatment of these two drugs.

Key words: Rifampin, Isoniazid, Drug hypersensitivity, Hypersensitivity, delayed-type, Desensitization, immunology, Review

Chao-gang XIONG,Fei REN,Xiao-hui LYU,Lei-peng REN,Jun ZHOU,Ying LI. Research progress of desensitization therapy and cutaneous adverse drug reactions induced by rifampicin and isoniazid[J]. Journal of Tuberculosis and Lung Health , 2018, 7(4): 323-327. doi: 10.3969/j.issn.2095-3755.2018.04.019

Figures/Tables 2

References 35

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时间(d)	时间点	利福平(mg)	配置液
1	9:00am	0.0003(1ml配置液)	300mg溶解于1000000ml水中
	6:00pm	0.0009(3ml配置液)	300mg溶解于1000000ml水中
2	9:00am	0.003(1ml配置液)	300mg溶解于100000ml水中
	6:00pm	0.009(3ml配置液)	300mg溶解于100000ml水中
3	9:00am	0.03(1ml配置液)	300mg溶解于10000ml水中
	6:00pm	0.09(3ml配置液)	300mg溶解于10000ml水中
4	9:00am	0.3(1ml配置液)	300mg溶解于1000ml水中
	6:00pm	0.9(3ml配置液)	300mg溶解于1000ml水中
5	9:00am	3(1ml配置液)	300mg溶解于100ml水中
	6:00pm	6(3ml配置液)	300mg溶解于100ml水中
6	9:00am	12(4ml配置液)	300mg溶解于100ml水中
	6:00pm	24(8ml配置液)	300mg溶解于100ml水中
7	9:00am	30(1ml配置液)	300mg溶解于10ml水中
	6:00pm	60(2ml配置液)	300mg溶解于10ml水中
8	9:00am	90(3ml配置液)	300mg溶解于10ml水中
	6:00pm	120(4ml配置液)	300mg溶解于10ml水中
9	9:00am	150(5ml配置液)	300mg溶解于10ml水中
	6:00pm	180(6ml配置液)	300mg溶解于10ml水中
10	9:00am	210(7ml配置液)	300mg溶解于10ml水中
	6:00pm	240(8ml配置液)	300mg溶解于10ml水中
11	9:00am	240(8ml配置液)	300mg溶解于10ml水中
	6:00pm	240(8ml配置液)	300mg溶解于10ml水中
12~13	9:00am	300	300mg/片
14	9:00am	450	450mg/片