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[1]	Elchert JA, Mansoor E, Abou-Saleh M, et al. Epidemiology of Whipple’s Disease in the USA Between 2012 and 2017: A Population-Based National Study. Dig Dis Sci, 2019, 64(5):1305-1311. doi:10.1007/s10620-018-5393-9.
[2]	Boumaza A, Ben Azzouz E, Arrindell J, et al. Whipple’s disease and Tropheryma whipplei infections: from bench to bedside. Lancet Infect Dis, 2022, 22(10):e280-e291. doi:10.1016/S1473-3099(22)00128-1. pmid: 35427488
[3]	Hannachi N, Arregle F, Lepidi H, et al. A Massive Number of Extracellular Tropheryma whipplei in Infective Endocarditis: A Case Report and Literature Review. Front Immunol, 2022, 13:900589. doi:10.3389/fimmu.2022.900589.
[4]	Abu Al Ghanam O, Mudhar HS, Spiteri-Cornish K, et al. Chronic Bilateral Uveitis as the Presenting Manifestation of Ocular Whipple’s Disease Confirmed by Vitreous PCR. Ocul Immunol Inflamm, 2025, 33(10):2577-2580. doi:10.1080/09273948.2025.2588212.
[5]	Marth T, Moos V, Müller C, et al. Tropheryma whipplei infection and Whipple’s disease. Lancet Infect Dis, 2016, 16(3):e13-e22. doi:10.1016/S1473-3099(15)00537-X.
[6]	Zhang WM, Xu L. Pulmonary parenchymal involvement caused by Tropheryma whipplei. Open Med (Wars), 2021, 16(1):843-846. doi:10.1515/med-2021-0297.
[7]	林嘉萍, 欧旸, 俞晓玲, 等. 惠普尔养障体肺炎1例报告并文献复习. 临床肺科杂志, 2024, 29(2):317-322. doi:10.3969/j.issn.1009-6663.2024.02.031.
[8]	Sun X, Gong Q. A case report of AIDS complicated by Pneumocystis jirovecii and Tropheryma whipplei mixed pulmonary infection identified via metagenomic next-generation sequencing. Front Med (Lausanne), 2025, 12:1599261. doi:10.3389/fmed.2025.1599261.
[9]	Winberg CD, Rose ME, Rappaport H. Whipple’s disease of the lung. Am J Med, 1978, 65(5):873-880. doi:10.1016/0002-9343(78)90809-4. pmid: 81613
[10]	Deng Y, Zhang H, Lu J, et al. Whipple’s disease of the respiratory system: A case report. Exp Ther Med, 2024, 27(4):133. doi:10.3892/etm.2024.12421. pmid: 38414785
[11]	Zhou JJ, Ding WC, Liu YC, et al. Diagnostic Value of Metagenomic Next-Generation Sequencing for Pulmonary Infection in Intensive Care Unit and Non-Intensive Care Unit Patients. Front Cell Infect Microbiol, 2022, 12:929856. doi:10.3389/fcimb.2022.929856.
[12]	Lin M, Wang K, Qiu L, et al. Tropheryma whipplei detection by metagenomic next-generation sequencing in bronchoalveolar lavage fluid: A cross-sectional study. Front Cell Infect Microbiol, 2022, 12:961297. doi:10.3389/fcimb.2022.961297.
[13]	Song X, Duan R, Duan L, et al. Current knowledge of the immune reconstitution inflammatory syndrome in Whipple disease: a review. Front Immunol, 2023, 14:1265414. doi:10.3389/fimmu.2023.1265414.
[14]	Günther U, Moos V, Offenmüller G, et al. Gastrointestinal diagnosis of classical Whipple disease: clinical, endoscopic, and histopathologic features in 191 patients. Medicine (Baltimore), 2015, 94(15):e714. doi:10.1097/MD.0000000000000714.
[15]	Grover SB, Grover H, Antil N, et al. Imaging Approach to Pulmonary Infections in the Immunocompromised Patient. Indian J Radiol Imaging, 2022, 32(1):81-112. doi:10.1055/s-0042-1743418.
[16]	Fang Z, Liu Q, Tang W, et al. Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series. Heliyon, 2023, 9(6):e17132. doi:10.1016/j.heliyon.2023.e17132.
[17]	尹辛大, 许明玲. 惠普尔养障体重症肺炎1例报告. 中国感染控制杂志, 2022, 21(8):812-815. doi:10.12138/j.issn.1671-9638.20222183.
[18]	池锐彬, 黎小红, 谢咏怡, 等. 惠普尔养障体致重症肺炎并肺脓肿及脓胸1例. 中国感染控制杂志, 2025, 24(8):1147-1149. doi:10.12138/j.issn.1671-9638.20252030.
[19]	Shi J, Liu R, Qiu J, et al. Pulmonary infection caused by Tropheryma whipplei: a case report and review of the literature. J Med Case Rep, 2024, 18(1):613. doi:10.1186/s13256-024-04936-y.
[20]	Boumaza A, Mezouar S, Bardou M, et al. Tumor Necrosis Factor Inhibitors Exacerbate Whipple’s Disease by Reprogramming Macrophage and Inducing Apoptosis. Front Immunol, 2021, 12:667357. doi:10.3389/fimmu.2021.667357.
[21]	Caillet Portillo D, Puéchal X, Masson M, et al. Diagnosis and treatment of Tropheryma whipplei infection in patients with inflammatory rheumatic disease: Data from the French Tw-IRD registry. J Infect, 2024, 88(2):132-138. doi:10.1016/j.jinf.2023.12.010. pmid: 38141787
[22]	Feurle GE, Moos V, Bläker H, et al. Intravenous ceftriaxone followed by 12 or three months of oral treatment with trimethoprim-sulfamethoxazole in Whipple’s disease. J Infect, 2013, 66(3): 263-270. doi:10.1016/j.jinf.2012.12.004.
[23]	Moos V, Krüger J, Allers K, et al. Oral treatment of Whipple’s disease with doxycycline and hydroxychloroquine versus intravenous therapy with ceftriaxone followed by oral trimethoprim-sulfamethoxazole in Germany: a phase 2/3, prospective, open-label, randomised, controlled, non-inferiority trial. Lancet Infect Dis, 2025, 25(7): 788-800. doi:10.1016/S1473-3099(24)00797-7.

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