Research progress on the correlation between pyroptosis and metastasis of non-small cell lung cancer

doi:10.19983/j.issn.2096-8493.2024082

Abstract

Abstract:

With the increasing incidence and mortality of non-small cell lung cancer (NSCLC), the focus and challenge of researches have been shifted towards delaying disease progression and prolonging patient survival. Metastasis is an inevitable aspect of tumor development which significantly affects patients’ median length of survival. Therefore, predicting metastasis occurrence and conducting preventive treatment are crucial for improving NSCLC prognosis. Some researchers have raised concerns about pyroptosis as a programmed cell death mode that can be expressed in both normal tissue and tumor cells, with distinctive biological effects in different types of tumor. This paper provides a summary of different activation pathways and application values of pyroptosis, focusing on its dual role in NSCLC metastasis. It suggests that pyroptosis may play an important role in targeted metastasis when considering current researches on brain metastasis of non-small cell lung cancer, offering a new approach to study the correlation between cell pyroptosis and NSCLC metastasis.

Key words: Carcinoma, non-small-cell lung, Neoplasm metastasis, Research, Pyroptosis

CLC Number:

R730.3

Chang Yuting, Zhang Xinran, Han Gaohua. Research progress on the correlation between pyroptosis and metastasis of non-small cell lung cancer[J]. Journal of Tuberculosis and Lung Disease , 2024, 5(3): 260-266. doi: 10.19983/j.issn.2096-8493.2024082

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