Abstract:

Objective: To analyze the epidemiological characteristics and treatment outcomes of pulmonary tuberculosis (PTB) with positive etiology in Tongzhou, Beijing, and to provide scientific evidence for the formulation of PTB prevention and control measures. Methods: The clinical data of PTB patients registered in Tongzhou, Beijing from 2012 to 2021 were collected from Tuberculosis Management Information System of China Information System for Disease Control and Prevention. A total of 4996 cases of PTB patients were registered, among which 1926 cases were positive in etiological examination. The information of PTB patients with positive etiology were collected, including household registration, gender, age, ethnicity, occupation, cases source, treatment classification, complication and treatment outcomes, etc. The epidemiological characteristics of the population were analyzed, and the seasonal effect of time series was analyzed using seasonal index. Results: From 2012 to 2021, a total of 1926 PTB patients with positive etiology were registered in Tongzhou, Beijing, accounting for 38.55% (1926/4996). The registration rate of PTB patients with positive etiology showed an upward trend, increasing from 7.35/100000 (95/1.292 million) in 2012 to 15.41/100000 (284/1.843 million) in 2021, the difference was significant ($\chi_{\text {trend}}^2$=52.668, P=0.000). The positive rate of etiology in PTB patients also showed an upward trend, increasing from 28.19% (95/337) in 2012 to 50.18% (284/566) in 2021, and the difference was also significant ($\chi_{\text {trend}}^2$=36.652, P=0.000). The male-female ratio of patients was 2.10:1 (1304/622). The main age group was 15-44 years (55.61%, 1071/1926), the main occupation was housekeepers/unemployed people (38.84%, 748/1926), the main source of patients was due to referral from general hospitals (69.52%, 1339/1926), the visit delay were common (44.29%, 853/1926), and 59.40% (1144/1926) of patients with non-local residence registration. The prevalence of PTB with positive etiology was from June to September per year, and the seasonal indexes were 123.99,110.28,120.25 and 132.09, respectively. The overall treatment success rate was 91.07% (1754/1926). Of the patients, 47 (2.44%) were defaulted, 55 (2.86%) died, and 43 (2.23%) transferred to multidrug-resistant PTB. Conclusion: The registration rate and positive rate in etiology of PTB patients with positive etiology in Tongzhou, Beijing increased and showed seasonal variation from 2012 to 2021. The patients are mainly male, young adults, non-local, housekeepers/unemployed, with delayed visit and regional distribution, corresponding prevention and control strategies should be formulated according to the epidemiological characteristics.

Key words: Tuberculosis, pulmonary, Epidemiological studies, Treatment outcome