Research progress of animal models of emphysema

doi:10.19983/j.issn.2096-8493.20210157

Abstract

Abstract:

Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease with high morbidity and mortality. Emphysema is one of the main pathological manifestations of COPD whose development was related to protease-antiprotease imbalance, oxidative stress, cell inflammation, cell apoptosis and so on. However, the pathogenesis and mechanism of progression of emphysema have not been fully clarified. The establishment of disease animal model provides an effective and practical experimental platform for further understanding its physiological and pathological mechanism. This article reviews the established animal models of emphysema, methods and related progresses based on previous researches.

Key words: Pulmonary disease,chronic obstructive, Disease models,animal, Review literature as topic

CLC Number:

LUO Li-juan, CHEN Yan. Research progress of animal models of emphysema[J]. Journal of Tuberculosis and Lung Disease , 2022, 3(1): 60-64. doi: 10.19983/j.issn.2096-8493.20210157

Figures/Tables 1

References 51

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建模方法	优点	缺点
香烟烟雾暴露诱发的肺气肿模型	与人类吸烟诱导的发病过程相似,产生类似于人类的生理变化,包括肺气肿、气流阻塞和肺动态顺应性降低等;低成本	建模周期相对较长
香烟烟雾提取物腹腔注射诱导的肺气肿模型	操作简单,建模周期短,低成本	与人类肺气肿的发展过程不完全一致
弹性蛋白酶诱导的肺气肿模型	操作简单,建模周期短,快速起病,低成本	弹性蛋白诱导的急性起病与人类肺气肿慢性进展不完全一致
化学物质刺激诱导的肺气肿模型	操作简单,建模周期短,低成本	与人类肺气肿的发展过程不完全一致
与基因相关诱导的肺气肿模型	阐明各种不同的基因在肺气肿发病机制中的作用	技术要求及成本较高