Abstract: Objective In order to provide evidence for improving the quality of tuberculosis (TB) treatment service in Guangxi, a investigation of patients satisfaction with TB treatment was conducted among pulmonary TB (PTB) patients.Methods Six counties with different models of TB control were selected as the investigation sites, including 2 counties implementing the CDC Model, 2 counties implementing the TB designated hospital model, 1 county implementing the TB hospital model and 1 county implementing the independent TB dispensary model. In each country, 5% of each type of notified PTB patients (i.e. new smear-positive, new smear-negative and retreatment smear-positive PTB patients) was enrolled in this study. A self-designed questionnaire was used for the face to face interviews to the enrolled patients. Constitute ratios of patients satisfaction were calculated; Chi-square test and fisher’s exact test were used to analyze the patients satisfaction with treatment costs, a value of P<0.05 was regarded as a significant difference.Results A total of 102 PTB patients were enrolled in this study. All those patients received complete interview and all questionnaires were valid for analysis. The effective response rate was 100.0%. The degrees of patients satisfaction with five items which were investigated were as follows (from high to low): attitude of health workers (94.1%, 96/102), health education on TB (92.2%, 94/102), environment of TB clinic (81.4%, 83/102), procedures of diagnosis and treatment (78.4%, 80/102), as well as the total treatment costs (41.2%, 42/102); the overall patients satisfaction with treatment was 77.5% (395/510). The patients satisfaction with the total treatment costs was different in counties implementing different TB control models: it was 35.7% (10/28) in the CDC model counties, 30.8% (8/26) in the TB designated hospital model counties, 33.3% (9/27) in the TB hospital model county and 71.4% (15/21) in the independent TB dispensary model county; a significant difference (χ²=10.128, P=0.018) was showed, and the patients in the TB designed hospital model counties had the lowest satisfaction with the total treatment costs (30.8%, 8/26).Conclusion TB patients were more satisfied with the health workers’ attitude and the health education on TB that was provided by the health workers. Howe-ver, the TB clinic environment and the procedures of diagnosis and treatment need to be improved; measures for reducing the financial burden of TB patients need to be explored.