Abstract: Objective To evaluate the therapeutic effect and application value of radiofrequency ablation (RAF) for advanced non-small cell lung cancer (NSCLC).Methods From April 2004 to December 2012 1373 patients with NSCLC were treated by RAF. The early treatment results, median survival time and 1-5 year survival rates were observed.Results The effective rate (CR+PR+NC/CR+PR+NC+PD)was 92.15%(1139/1236). 672 cases survived over one year and the 1 year survival rate was 54.37% (672/1236). Two hundred and one cases survived over 2 years and the 2 year survival rate was 40.52% (201/496). Eighty-seven cases survived over three years and the 3 year survival rate was 15.10%(87/576). Twenty-two cases survived over 5 years and the 5 year survival rate was 9.61% (22/229).Conclusion The early and mid-term effects of RAF on non-small cell lung cancer is satisfactory.