Research progress on the role of interleukin-24 in lung-related diseases

doi:10.19983/j.issn.2096-8493.20250019

Abstract

Abstract:

Interleukin-24 (IL-24), a key member of the IL-10 cytokine family, is widely expressed in immune system-related tissues and cells. In response to inflammatory conditions or external micro-environmental stimuli, IL-24 activates signaling pathways such as STAT, ERK, and SOCS, through binding to receptors either intracellularly or extracellularly after secretion. This activation promotes immune cells chemotaxis and expression, thereby contributing to the pathophysiological processes of various pulmonary diseases. Expression levels of IL-24 are associated with non-small cell lung cancer, pulmonary fibrosis, asthma and other lung-related disorders. Targeting IL-24 and its receptors has shown potential to mitigate disease progression and improve prognosis. This review highlights the latest research progress on IL-24 in pulmonary diseases, aiming to provide valuable insights into its mechanisms and therapeutic applications.

Key words: Interleukin-24 (IL-24), Immune regulation, Lung disease, Summarize

CLC Number:

R393.12
R563

Zhu Mengyang, Xiao Li, Zhang Tao. Research progress on the role of interleukin-24 in lung-related diseases[J]. Journal of Tuberculosis and Lung Disease , 2025, 6(4): 472-476. doi: 10.19983/j.issn.2096-8493.20250019

Figures/Tables 1

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