嗜血细胞性淋巴组织增生症患者的呼吸系统临床及影像学表现

结核病与肺部健康杂志 ›› 2013, Vol. 2 ›› Issue (2): 86-91.

嗜血细胞性淋巴组织增生症患者的呼吸系统临床及影像学表现

陶连琴，王一佳，时国朝

200025 上海交通大学医学院附属瑞金医院呼吸科
陶连琴、王一佳为并列第一作者

收稿日期:2013-04-29 出版日期:2013-06-30 发布日期:2013-06-30
通信作者: 时国朝,Email:shiguochao@hotmail.com

Respiratory manifestation and imageology in patient with hemophagocytic lymphohistiocytosis

TAO Lian-qin,WANG Yi-jia,SHI Guo-chao

Department of Respiratory Medicine,Ruijin Hospital,Shanghai Jiao Tong University of Medicine,Shanghai 200025,China

Received:2013-04-29 Online:2013-06-30 Published:2013-06-30
Contact: SHI Guo-chao,Email:shiguochao@hotmail.com

摘要/Abstract

摘要： 目的总结与分析嗜血细胞性淋巴组织增生症(hemophagocytic lymphohistiocytosis,HLH)患者的呼吸系统临床及影像学表现,以期改善HLH的早期诊断。方法回顾性分析2006年以来在上海交通大学医学院附属瑞金医院住院、并确诊为HLH患者(11例)的临床表现及胸部影像学特征。结果HLH患者呼吸系统的症状主要表现为咳嗽(5例)、胸闷(6例)、气促(5例)。在胸部影像学检查方面,X线胸片(共3例)主要表现为肺部磨玻璃样影(2例)、结节病灶(3例);CT(共8例)主要表现为肺部磨玻璃样影(3例)、纵隔淋巴结肿大(5例)、胸腔积液(7例)、胸膜增厚(6例)等。结论HLH的呼吸系统临床症状和影像学表现不具有特征性,但呼吸衰竭和弥漫性磨玻璃样改变可能是重症HLH的呼吸系统表现,需要及时识别。

Abstract: Objective Hemophagocytic lymphohistiocytosis(HLH)is a nonmalignant disorder of immune re-gulation,with nonspecific symptoms and multiple organs affected. Aim of our study is to investigate the clinical and imaging charateristics of respiratory system in HLH patients so as to help to improve the early diagnosis of HLH.Methods Clinical features and radiological manifestations of confirmed HLH patients in Ruijin Hospital since 2006 were retrospectively reviewed.Results Eleven cases of HLH were enrolled in our study,whose major signs and symptoms of respiratory system are cough,dyspnea and tachypnea. Ground-glass opacities(2 cases)and nodular lesion(3 cases)were the main features of chest radiographs(3 cases totally),meanwhile ground-glass opacities(3 cases),mediastinal lymphadenectasis(5 cases),pleural effusion(7 cases)and pleural thickening(6 cases)were also the main features of chest CT(8 cases totally).Conclusion Although both clinical features and radiological changes of respiratory system are nonspecific,respiratory failure and diffused ground-glass opacity are recognized as important features in severe HLH.

陶连琴，王一佳，时国朝. 嗜血细胞性淋巴组织增生症患者的呼吸系统临床及影像学表现[J]. 结核病与肺部健康杂志, 2013, 2(2): 86-91.

TAO Lian-qin,WANG Yi-jia,SHI Guo-chao. Respiratory manifestation and imageology in patient with hemophagocytic lymphohistiocytosis[J]. Journal of Tuberculosis and Lung Health, 2013, 2(2): 86-91.

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