Abstract: The incidence and mortality of lung cancer ranks first in China, and surgery operation is the only way to cure lung cancer. However, only 20%to 30% of patients are suitable for curative resection. In recent years, tumor physical targeted therapies are widely used in clinic. Tumor physical therapy targeting technology means under the minimally invasive condition, setting the tumor as the goal, to maximize the eradication of target tumor cells and normal tissue around 1cm, to ensure the radical cure and maximum protection of normal lung tissue. This technology has the advantages of minimal invasion, safe, conformal, less complications, local anesthesia, simple operation, fast recovery, repeatable, reliable effect, and is easily accepted by patients, which has been proved to be a promising therapeutic tool. At present, the lung cancer physical target includes cryoablation, radiofrequency ablation, microwave ablation and radioactive seed implantation, the status and progress of the CT-guided radiofrequency ablation in the treatment of non-small cell lung cancer was reviewed.