结核病与肺部健康杂志 ›› 2017, Vol. 6 ›› Issue (3): 204-207.doi: 10.3969/j.issn.2095-3755.2017.03.000

• 专论 • 上一篇    下一篇

实验动物结核病病变程度的评价

包容   

  1. 430071武汉大学动物实验中心 ABSL-3实验室,病理室
  • 收稿日期:2017-05-17 出版日期:2017-09-30 发布日期:2017-09-30
  • 作者简介:包容
  • 基金资助:
    国家“十二五”科技重大专项(2013ZX10003009-003)

Evaluation of tuberculosis in experimental animals

BAO Rong   

  1. Pathology Laboratory, Center for Animal Experiment/Animal Biosafety Level 3 Laboratory, Wuhan University School of Medicine, Wuhan430071, China
  • Received:2017-05-17 Online:2017-09-30 Published:2017-09-30

摘要: 结核病病变程度是对结核病疫苗及抗结核化学药物安全性、有效性进行评价时非常需要确定的问题,可以反映结核病动物模型干预因素(如药物、疫苗、菌株毒力等)的效果,这对于相关药物、疫苗的研发具有重要参考意义。结核病病变程度的量化可以为结核病疫苗、药物筛选提供更为可靠的方法。

Abstract: The lesion of tuberculosis is important for safety and efficacy evaluation of vaccine and drug against tuberculosis, it could indicate the effect of drug, vaccine and strain virulence in tuberculosis (TB) animal model, which is very important for related investigation. Evaluation of tuberculosis may provide a reliable method for vaccine and drug development against anti-tuberculosis.