结核病与肺部健康杂志 ›› 2014, Vol. 3 ›› Issue (2): 115-119.doi: 10.3969/j.issn.2095-3755.2014.02.009

• 论著 • 上一篇    下一篇

卡介菌和结核菌素纯蛋白衍生物在学校结核病密切接触者筛查中的结果分析

袁磊凌, 谭少清, 李家政, 吴智龙   

  1. 528000 广东省佛山市第四人民医院结核病防治质量控制科
  • 收稿日期:2013-10-29 出版日期:2014-04-20 发布日期:2014-04-20
  • 通信作者: 袁磊凌,Email:y2287958@126.com

The analysis of bacillus Calmette-Guérin purified protein derivative and tuberculin purified protein derivative in tuberculosis screening among tuberculosis close contacts in school

YUAN Lei-ling, TAN Shao-qing, LI Jia-zheng, WU Zhi-long.   

  1. Department of Tuberculosis Quality Control,the Fourth People’s Hospital of Foshan, Foshan 528000, China
  • Received:2013-10-29 Online:2014-04-20 Published:2014-04-20
  • Contact: YUAN Lei-ling,Email:y2287958@126.com

摘要: 目的 分析不同纯蛋白衍生物(PPD)试剂在学校结核病密切接触者筛查中的结果,为学校结核病密切接触者结核病筛查工作提供参考依据。方法 按照学校结核病患者发现的顺序,用卡介菌纯蛋白衍生物(BCG-PPD)和结核菌素纯蛋白衍生物(TB-PPD)分别对11间和5间学校的结核病密切接触者进行了PPD试验(共计1098名)。72h后观察结果,皮肤硬结平均直径≥5mm为阳性,≥15mm或局部有水泡、坏死、淋巴管炎为强阳性,<5mm为阴性。阳性率、强阳性率和阴性率的差异性比较采用SPSS 16.0统计软件进行χ2检验,P<0.05为差异有统计学意义。结果 846名密切接触者接受了BCG-PPD试验,阳性574名,阳性率为67.85%;强阳性178名,强阳性率为21.04%;阴性94名,阴性率为11.11%;强阳性者检出活动性肺结核2例,检出率为1.12%。252名接触者接受了TB-PPD试验,阳性68名,阳性率为26.98%;强阳性13名,强阳性率为5.16%;阴性171名,阴性率为67.86%,强阳性者检出活动性肺结核1例,检出率为7.69%。两组不同PPD的试验结果包括阳性率、强阳性率和阴性率差异有统计学意义(阳性率、强阳性率和阴性率的χ2值分别为133.53、34.08、341.47,P值均<0.05),强阳性者活动性肺结核检出率差异无统计学意义(χ2=0.47,P>0.05)。结论 不同PPD试剂的试验结果差异较大,在开展学校结核病密切接触者筛查工作中应该从防止漏检的角度出发择优选择PPD试剂。

Abstract: Objective Analyzed the different varieties of purified protein derivative(PPD) used in screening of tuberculosis for tuberculosis close contacts in school, providing reference for school TB screening.Methods According to the sequences of tuberculosis cases found in school, purified protein derivative bacillus Calmette-Guérin(BCG-PPD) and purified protein derivative of tuberculin(TB-PPD) tests for tuberculosis close contacts were carried out respectively in 11 and 5 schools(1098 cases).The results were observed after 72 hours. Skin induration ≥5 mm is positive, ≥15 mm or partially blisters, necrosis, lymphangitis were strongly positive, <5 mm were negative. The difference between the resistant rates was compared with χ2 test, and the significance level was set at P<0.05.Results 846 contacts had received BCG-PPD test, 574 were positive with positive rate of 67.85%; 178 were strong positive with the strong positive rate of 21.04%, 94 were negative with the negative rate of 11.11%.; 2 cases of active pulmonary tuberculosis were detected in Strong positive students, with the detection rate of 1.12%. 252 contacts had accepted TB-PPD test, 68 were positive with the positive rate of 26.98%; 13 were strong positive with the strong positive rate of 5.16%, 171 were negative with the negative rate of 67.86%.; 1 cases of active pulmonary tuberculosis were detected in strong positive students with the detection rate of 7.69%. Result rates of the two groups had significant statistical differences (The positive rate, positive rate and the negative rate of χ2=133.53, 34.08, 341.47, P<0.05). The detection rate of active pulmonary tuberculosis among strong positive population were not statistically significant different(χ2=0.47,P>0.05).Conclusion Different reagents for PPD test results varied, In school TB close contacts screening, PPD selection should from the perspective of preventing the undetected TB patients.