Abstract: Objective To investigate the efficacy of tuberculous otitis media treated with different antituberculous drugs dropping and douching combination with nursing intervention.Methods Twenty-seven cases with tuberculous otitis media in our hospital during the Mar,2005 to the Feb, 2012 were divided randomly into 2 groups by different antituberculous drugs ear dropping and douching combination with nursing interventions, meanwhile all patients received antituberculous drugs treatment. Fifteen patients were treated with the isoniazid and rifampin ear dropping and douching in group A and 12 cases were treated with the ofloxacin ear dropping and douching in group B. Clinical efficacy were compared between groups. We adopted EpiData 3.0 software to establish database,and ana-lyzed the data with SPSS 13.0 software. Efficacy was evaluated on the basis of dry ear time, tympanic membrane closure and whether need to operate or not at the end of ear dropping and douching. The data were analyzed using four exact probability test table and the difference was statistically significant with P<0.05.Results After 2 months of treatment, there were 13 cases with dry ear in group A and 1 cases in group B. The others were ear dry in group A and group B at the 3rd month(χ²=16.3836,P＜0.05). At the end of treatment, there were 0 case required mastoid surgery in group A and 4 cases in group B(χ²=5.8696,P＜0.05). There were 6 cases with tym-panic membrane closure while 9 cases with tympanic membrane perforation in group A. But there were 0 case with tympanic membrane closure while 12 cases with tympanic membrane perforation in group B. The difference was significant statistically(χ²=6.1714,P＜0.05). Followed up for 1 year, none of 27 patients recurred.Conclusion Nursing interventions combination with antituberculous drugs ear dropping and douching are effective for tuberculous otitis media in 2 groups. According to the dry ear time, tympanic membrane closure and whether need to ope-rate, group A shows better curative effect than group B. Therefore, it is recommended that the isoniazid and rifampin ear drops in the treatment of tuberculous otitis media should be prior to application.