Abstract: The epidemic of Multi-drug resistance Tuberculosis (MDR-TB) is very serious in China. Globally China is the largest country of MDR-TB. The control and prevention of MDR-TB admits of no delay. The author reviewed the measures of programmatic treatment and management of MDR-TB issued by World Health Organization and control measures of non-MDR-TB in China, and put forward their views and recommendations for strengthening the management of MDR-TB which are of great significance in guiding the MDR-TB control and prevention in the coming period of time.