Transient receptor potential channels proteins and the pathogenesis of pulmonary hypertension

doi:10.3969/j.issn.2095-3755.2017.03.000

Abstract

Abstract: Pulmonary hypertension is one of the diseases that seriously threaten to human health with significant mortality and disability rate. It is vital to explore the mechanism of pathogenesis of pulmonary hypertension for its prevention and treatment. The increase in Ca2+ concentration of pulmonary artery smooth muscles cells enhances cell proliferation and consequent causes occurrence of pulmonary hypertension, which plays a core role in the pathogenesis of pulmonary hypertension. The Ca2+ concentration of cells is regulated by calcium channels on cell membrane. The transient receptor potential channel C (TRPC) is the main component of calcium channels, and TRPC1/4/6 are involved in pathogenesis of pulmonary hypertension. In the present article, we reviewed the pathogenesis of pulmonary hypertension in detail.

XU Lei, FU Xiu-hua. Transient receptor potential channels proteins and the pathogenesis of pulmonary hypertension[J]. Journal of Tuberculosis and Lung Health , 2017, 6(3): 279-293. doi: 10.3969/j.issn.2095-3755.2017.03.000

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