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Interpretation of WHO global tuberculosis report 2023 hu Wei, Liu Yuhong Journal of Tuberculosis and Lung Disease    2024, 5 (1): 15-19.   DOI: 10.19983/j.issn.2096-8493.2024006 Abstract （993）   HTML （89）    PDF（pc） （1076KB）（618）       Knowledge map    Save In November 2023, the World Health Organization published the Global tuberculosis report 2023, which focuses on the updated global burden of the tuberculosis epidemic, notifications, treatment outcomes, innovation, and development. The authors interpret the burden of global tuberculosis, status of diagnosis and treatment s of the Global Report and provides a reference for peers to comprehensively understand global strategies, actions, and progress on tuberculosis prevention and control. Reference | Related Articles | Metrics

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Clinical practice guidelines for early detection of pulmonary tuberculosis in general medical facilities National Center of Medical Quality Control for Respiratory Diseases , Tuberculosis Branch of Chinese Medical Association , Tuberculosis Control Branch of Chinese Antituberculosis Association , China⁃Japan Friendship Hospital Journal of Tuberculosis and Lung Disease    2024, 5 (1): 1-14.   DOI: 10.19982/j.issn.1000-6621.20230428 Abstract （436）   HTML （48）    PDF（pc） （3750KB）（404）       Knowledge map    Save The diagnosis delay of pulmonary tuberculosis not only results in aggravation and treatment challenges for patients but also leads to the continuously group spreading of tuberculosis. Early detection in general medical facilities, the main primary diagnosis healthcare contact for pulmonary tuberculosis patients, plays a crucial role in achieving the goal of “End tuberculosis strategy”. The National Center of Medical Quality Control for Respiratory Diseases, Tuberculosis Branch of Chinese Medical Association, Tuberculosis Control Branch of Chinese Antituberculosis Association, and China-Japan Friendship Hospital jointly organized experts to formulate the Clinical practice guidelines for early detection of pulmonary tuberculosis in general medical facilities based on the results of China’s tuberculosis prevention practice and the relevant guidelines of the World Health Organization and supplement relevant research evidence at home and abroad. The guideline systematically summarizes the characteristics of different diagnostic techniques for pulmonary tuberculosis and proposes tuberculosis screening strategies for different target populations seeking treatment in comprehensive medical institutions, providing evidence for improving and optimizing early detection of pulmonary tuberculosis in national and regional comprehensive medical institutions. Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Disease    2024, 5 (4): 279-282.   DOI: 10.19983/j.issn.2096-8493.2024052 Abstract （373）   HTML （12）    PDF（pc） （1106KB）（57）       Knowledge map    Save Reference | Related Articles | Metrics

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Research progress on continuous nursing of patients with chronic obstructive pulmonary disease Qu Chunjin, Peng Jiayi, Liu Xinyi, Xiao Guanchen, Gu Fen, Li Nannan Journal of Tuberculosis and Lung Disease    2024, 5 (3): 254-259.   DOI: 10.19983/j.issn.2096-8493.2024063 Abstract （320）   HTML （23）    PDF（pc） （760KB）（101）       Knowledge map    Save Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by persistent respiratory symptoms and restricted airflow. With the increasing aging population and worsening environmental pollution, the incidence and mortality of COPD are on the rise. Continuous nursing, as an effective mode of chronic disease management, realizes the transition from hospital to community and home nursing through regular follow-up, personalized education and self-management support. Therefore, continuous nursing of COPD is of great significance for improving patients’ quality of life and prognosis. The author reviewed the current status, implementation models, intervention studies and other aspects of COPD continuous nursing for patients both domestically and internationally, aiming to offer insights for the development of COPD continuous nursing tailored to the Chinese context. Reference | Related Articles | Metrics

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Research progress of tuberculosis screening and preventive treatment in senior high school students Wei Jing Ru, Chen Hui, Cheng Jun Journal of Tuberculosis and Lung Disease    2024, 5 (4): 358-363.   DOI: 10.19983/j.issn.2096-8493.2024072 Abstract （294）   HTML （9）    PDF（pc） （931KB）（135）       Knowledge map    Save Students are a high-risk group for tuberculosis, among whom senior high school students have the highest proportion of pulmonary tuberculosis patients. Carrying out tuberculosis screening and subsequent preventive treatment interventions among senior high school students is essential in reducing incidence and transmission of tuberculosis, thereby lowering the risk of school outbreaks. The authors reviewed relevant literature focused on pulmonary tuberculosis among middle school students published in 2010—2024,illustrating the current status and research progress of tuberculosis screening of senior high school students and intervention and treatment of patients with latent tuberculosis infection, aiming to provide reference and insight for tuberculosis screening and follow-up intervention treatment for senior high school students. Reference | Related Articles | Metrics

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Single nucleotide polymorphisms and related genes in Chinese children with type 2 inflammatory asthma Su XingYue, Wang Beilei, Ma Xiang Journal of Tuberculosis and Lung Disease    2024, 5 (4): 370-375.   DOI: 10.19983/j.issn.2096-8493.2024086 Abstract （270）   HTML （5）    PDF（pc） （939KB）（40）       Knowledge map    Save Bronchial asthma is a chronic inflammatory disease that significantly impacts the physical and mental health of children. It is classified into type 2 inflammatory asthma and non-type 2 inflammatory asthma based on distinct mechanisms and manifestations of inflammation. Type 2 inflammatory asthma represents a substantial proportion of pediatric asthma cases, characterized by severe symptoms and poor clinical outcomes. The pathogenesis of asthma is complex, with genetic variation playing a critical role in its onset and progression. Developing diagnostic models and individualized treatment plans from a genetic perspective is therefore of paramount importance. The authors systematically summarizes current research on gene regions and single nucleotide polymorphisms associated with type 2 asthma, aiming to elucidate the relationship between genetic factors and the development of asthma, and to provide a foundation for future predictive diagnostic models and individualized treatment strategies for asthma. Reference | Related Articles | Metrics

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Current status of diagnosis and clinical treatment on co-existent pulmonary tuberculosis and lung cancer Yang Hongjie, Qi Fei, Zhang Hongmei, Wu Hongbo, Hu Aimin, Zhang Tongmei Journal of Tuberculosis and Lung Disease    2024, 5 (3): 273-278.   DOI: 10.19983/j.issn.2096-8493.2024054 Abstract （252）   HTML （11）    PDF（pc） （709KB）（109）       Knowledge map    Save Lung cancer and pulmonary tuberculosis are two major respiratory diseases that seriously endanger human health. Each disease causes about 1.6 million deaths per year worldwide. Particularly in developing countries, there are high incidences of both diseases. Epidemiological evidence suggests that pulmonary tuberculosis increases the risk of lung cancer. The clinical symptoms of pulmonary tuberculosis and lung cancer are too similar, the co-existence and mutual influence of the two diseases make it difficult to diagnose and treat them, which brings a huge burden to patients. This paper reviews the pathogenesis, diagnosis and treatment of lung cancer complicated with pulmonary tuberculosis. Reference | Related Articles | Metrics

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Research progress on influencing factors and intervention strategies of stigma in patients with pulmonary tuberculosis Zhao Jun, Yang Hongyu, Kang Xiong Journal of Tuberculosis and Lung Disease    2024, 5 (4): 364-369.   DOI: 10.19983/j.issn.2096-8493.2024080 Abstract （247）   HTML （3）    PDF（pc） （871KB）（91）       Knowledge map    Save Pulmonary tuberculosis is a chronic respiratory infectious disease that seriously threatens people’s health due to its long course of disease, strong contagiosity and high mortality. Pulmonary tuberculosis patients generally have different degrees of stigma which could make different degrees of impact on patients’ compliance behavior, disease outcome, mental state, quality of life and so on. The authors reviews the research status, assessment tools, influencing factors and intervention strategies of stigma in patients with pulmonary tuberculosis at home and abroad, in order to provide a reference for clinical intervention of stigma in patients with pulmonary tuberculosis. Reference | Related Articles | Metrics

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Research progress of comprehensive treatment for tuberculosis Liang Chen, Tang Shenjie, Lin Minggui Journal of Tuberculosis and Lung Disease    2024, 5 (1): 70-80.   DOI: 10.19983/j.issn.2096-8493.20230112 Abstract （246）   HTML （24）    PDF（pc） （1006KB）（171）       Knowledge map    Save Tuberculosis is a chronic infectious disease caused by the infection of Mycobacterium tuberculosis complex. Although the success of BCG vaccine and effective anti-tuberculosis drugs has provided effective means of tuberculosis prevention and treatment, it is still quite challenging to cure tuberculosis completely with the continuous flow of population, and continuous emergence of HIV infection, usage of immunosuppressive drugs for special diseases and drug-resistant tuberculosis, especially for that the prevalence of COVID-19 since the end of 2019 has set back the epidemic control of tuberculosis for at least 5-8 years. Curing tuberculosis patients thoroughly is still the key measure to cut off the transmission of Mycobacterium tuberculosis and eliminate disease transmission. On the basis of anti-tuberculosis chemotherapy, combined with comprehensive treatment methods such as surgical treatment, interventional therapy, immunotherapy, nutritional therapy, traditional Chinese medicine treatment, psychological therapy, and rehabilitation therapy, it is beneficial to improve the patient’s cure rate and reduce adverse reactions. Clinicians need to comprehensively evaluate the specific condition of patients and choose individualized comprehensive treatment plans in a targeted manner to achieve the optimal treatment effect. This article reviews the research progress of tuberculosis comprehensive treatment in recent years. Reference | Related Articles | Metrics

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Current status and prospects of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease Wang Lin, Zhang Zinan Journal of Tuberculosis and Lung Disease    2024, 5 (3): 191-196.   DOI: 10.19983/j.issn.2096-8493.2024056 Abstract （231）   HTML （17）    PDF（pc） （997KB）（93）       Knowledge map    Save Chronic obstructive pulmonary disease (COPD) is a common chronic disease in clinical practice, with a heavy social and economic burden. Pulmonary rehabilitation is the main non pharmacological treatment method for COPD. Currently, there is a lack of guidelines and standards for pulmonary rehabilitation, and clinical practice experience will accumulate more data for research related to pulmonary rehabilitation. The authors elaborate on the importance of pulmonary rehabilitation in patients with COPD, the difficulties in research, and future research directions, in order to enhance clinical understanding and importance of pulmonary rehabilitation in patients with COPD. Reference | Related Articles | Metrics

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Construction and prospects of tuberculosis prevention and control service system in China during the new era Chen Wei, Sun Huijuan, Zhao Yanlin Journal of Tuberculosis and Lung Disease    2024, 5 (2): 95-100.   DOI: 10.19983/j.issn.2096-8493.2024025 Abstract （217）   HTML （22）    PDF（pc） （1101KB）（92）       Knowledge map    Save The service system of tuberculosis prevention and control in China has been continuously adjusted and transformed with the changes in epidemic levels and the development of the economy and society. Since 2011, China has gradually implemented the new tuberculosis prevention and control service system. In the new era, how to better improve and perfect the tuberculosis prevention and control service system is a major issue facing tuberculosis prevention and control work. The authors systematically summarized the evolution of China’s tuberculosis prevention and control service system; described the current operation status of the tuberculosis prevention and control service system; analyzed the existing problems and challenges; and put forward the working opinions and suggestions on the construction of the tuberculosis prevention and control service system in the future. Table and Figures | Reference | Related Articles | Metrics

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Progress in tuberculosis infection screening, diagnosis and treatment of female infertility patients before in vitro fertilization-embryo transfer Li Yabo, Fan Lijuan, Sun Xiuli, Gou Liangzhi, Ren Beiying, Shi Juanzi, Wang Fang, Ma Xiaoling, Xie Yonghong, Liu Xin, Wu Qianhong Journal of Tuberculosis and Lung Disease    2024, 5 (4): 352-357.   DOI: 10.19983/j.issn.2096-8493.2024053 Abstract （211）   HTML （4）    PDF（pc） （934KB）（40）       Knowledge map    Save In vitro fertilization-embryo transfer (IVF-ET) is an effective method for treating female infertility. During IVE-ET course, patients with female reproductive system tuberculosis have certain risk of activating tuberculosis to recurrent, which leads to low success rate of IVF-ET and high incidence of adverse events. In China, large number of patients have active tuberculosis disease or tuberculosis latent infection. Screening for tuberculosis infection before IVF-ET in infertile women and then taking necessary intervention can improve the success rate of IVF-ET and reduce the incidence of adverse events. At present, there is no conclusion on standard treatment before IVE-ET for infertile women with female reproductive system tuberculosis infection. This article reviews the application of laboratory, imaging, endoscopic, and pathological examination and anti-tuberculosis treatment in screening, diagnosis and treatment of female reproductive system tuberculosis infection, in order to provide clinical reference for the screening and treatment of tuberculosis infection in infertile women before IVF-ET. Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Disease    2024, 5 (4): 376-378.   DOI: 10.19983/j.issn.2096-8493.2024022 Abstract （203）   HTML （13）    PDF（pc） （772KB）（72）       Knowledge map    Save Reference | Related Articles | Metrics

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Current situation of tuberculosis epidemic in schools and research progress in prevention and control Cao Hong, Qian Bing, Wu Jinju Journal of Tuberculosis and Lung Disease    2024, 5 (1): 88-92.   DOI: 10.19983/j.issn.2096-8493.20230115 Abstract （194）   HTML （14）    PDF（pc） （827KB）（118）       Knowledge map    Save In the special period of growth and development, unbalanced nutrition, high pressure for further education and employment, and other reasons, result in that students are at high-risk of tuberculosis (TB). Recently, TB clusters epidemic in schools have been reported, and clusters of mutidrug-resistant tuberculosis have also occurred, which seriously affected the physical and mental health of students and caused adverse social impacts. The author reviewed the current situation and prevention and control measures of TB in schools in recent years, summarized and analyzed the problems, and provided the basis for better control of TB in schools. Reference | Related Articles | Metrics

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New progress in research on the influencing factors of the severity of Mycoplasma pneumoniae pneumonia in children iu Liming, Li Ming Journal of Tuberculosis and Lung Disease    2024, 5 (1): 81-87.   DOI: 10.19983/j.issn.2096-8493.2024013 Abstract （182）   HTML （9）    PDF（pc） （871KB）（54）       Knowledge map    Save Mycoplasma pneumoniae (MP) infection is a heterogeneous disease. Clinically, in children diagnosed with Mycoplasma pneumoniae pneumonia (MPP), severe Mycoplasma pneumoniae pneumonia (SMPP), refractory Mycoplasma pneumoniae pneumonia (RMPP) and critical MPP, in addition to causing serious impacts on children’s life safety such as treatment difficulties and poor prognosis, various degrees of sequelae often exist. To explore the influencing factors and to improve the early warning indicators of MPP severity, is of great significance for early intervention, reducing the morbidity and sequelae of SMPP and RMPP, and reducing the mortality rate of SMPP and RMPP. In clinical practice, mycoplasma drug resistance, clinical manifestations, laboratory indicators, imaging manifestations, and the application of bronchoalveolar lavage (BAL) in children infected with MPP are related to the occurrence of MPP severity. This paper reviews the research progress of the above related factors. Reference | Related Articles | Metrics

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Research progress on the interaction between tuberculosis and COVID-19 He Fanyi, Lu Nihong, Du Yingrong Journal of Tuberculosis and Lung Disease    2024, 5 (4): 345-351.   DOI: 10.19983/j.issn.2096-8493.2024045 Abstract （178）   HTML （5）    PDF（pc） （1180KB）（14）       Knowledge map    Save Tuberculosis (TB) was one of the major respiratory infectious diseases threatening public health before the corona virus disease-2019 (COVID-19) pandemic. TB and COVID-19 have a common pathogenic pathway, mainly transmitted through respiratory droplets, and their clinical characteristics were similar. Co-infection of the two infectious diseases can cause a double burden, which not only aggravating the severity of COVID-19, but also worsening active TB, and even causing cytokine storms, leading to severe respiratory diseases and increasing the risk of death of patients. The COVID-19 pandemic also posed a serious challenge to the public health care system, significantly interfering with the health care services provided for TB patients, and further increasing the incidence and mortality of TB patients globally. Therefore, the authors provides a review of the research progress on the interactions between COVID-19 and TB, with the aim of providing reference for clinical research, diagnosis and treatment. Table and Figures | Reference | Related Articles | Metrics

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Current status and nursing research progress of long-term oxygen therapy for patients with chronic obstructive pulmonary disease Zhang Yidan, Gu Fen, Li Nannan Journal of Tuberculosis and Lung Disease    2024, 5 (3): 249-253.   DOI: 10.19983/j.issn.2096-8493.2024064 Abstract （176）   HTML （23）    PDF（pc） （686KB）（88）       Knowledge map    Save Chronic obstructive pulmonary disease (COPD) is the most common chronic airway disease characterized by airflow limitation and the third leading cause of death worldwide, imposing a significant health and economic burden worldwide. As the disease progresses, patients tend to develop hypoxemia, resulting in impaired cardiopulmonary function. Long-term oxygen therapy is an important measure to delay the progression of disease in patients with COPD, and the standardization of its development has not yet formed a unified standard. Therefore, this paper reviews and discusses the implementation status and nursing management plans of long-term oxygen therapy nursing for patients with COPD, so as to provide a reference for better long-term oxygen therapy nursing for COPD patients in the future. Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Disease    2024, 5 (3): 187-190.   DOI: 10.19983/j.issn.2096-8493.2024047 Abstract （170）   HTML （18）    PDF（pc） （1037KB）（71）       Knowledge map    Save Reference | Related Articles | Metrics

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Analysis of the epidemic characteristics of pulmonary tuberculosis in Shijingshan District, Beijing from 2012 to 2022 Zhang Yajing, Ren Lijun, Wang Mingliang, Jiang Ying, Zhou Lin, Tang Guiqin Journal of Tuberculosis and Lung Disease    2024, 5 (2): 158-163.   DOI: 10.19983/j.issn.2096-8493.2024023 Abstract （169）   HTML （9）    PDF（pc） （887KB）（60）       Knowledge map    Save Objective: To analyze the epidemiological characteristics of pulmonary tuberculosis in Shijingshan District of Beijing from 2012 to 2022, and provide scientific basis for better tuberculosis prevention and control in the future. Methods: The relevant data of tuberculosis patients in Shijingshan District from 2012 to 2022, including gender, age, occupation, etiology, current address, etc., were collected through the Tuberculosis Information Management System, a subsystem of the China Disease Prevention and Control Information System, and were analyzed by descriptive epidemiological methods. Results: A total of 1954 cases of pulmonary tuberculosis were reported in Shijingshan District from 2012 to 2022, with an annual reported incidence rate of 28.60/100000. The reported incidence rate of pulmonary tuberculosis decreased from 35.70/100000 (231 cases) in 2012 to 21.85/100000 (123 cases) in 2022, showing a general downward trend ($χ^{2}_{趋势}=40.035$, P<0.001). Among the reported pulmonary tuberculosis patients, the sex ratio of male and female was 1.93∶1 (1288∶666). The reported incidence rate of male (37.44/100000, 1288/3440000) was significantly higher than that of women (19.63/100000, 666/3392000)(χ2=189.416, P<0.001). The reported incidence rates of pulmonary tuberculosis of the three age groups of 0-14 years old, 15-64 years old, ≥65 years old and above were 2.76/100000 (19/688973), 25.69/100000 (1372/5341527) and 69.21/100000 (563/813409), respectively. The incidence rate in the age group of 65 years and above was significantly higher than those in the age groups of 0-14 years and 15-64 years (χ2=647.183, P<0.001). The top 5 occupational distribution groups were retirees (33.88%, 662/1954), household and unemployed (21.19%, 414/1954), cadres and staff (9.88%, 193/1954), workers (8.55%, 167/1954), and students and teachers (6.14%, 120/1954). The number of tuberculosis cases reported in the second quarter was the largest (26.36%, 515/1954), followed by the fourth quarter (25.03%, 489/1954), and the lowest number was in the first quarter (23.80%, 465/1954). Conclusion: From 2012 to 2022, the reported incidence rate of pulmonary tuberculosis in Shijingshan District showed a general downward trend. People aged 65 and above are the key population for tuberculosis prevention and control in Shijingshan District. Effective measures should be taken to make the detection and treatment for the elderly patients as soon as possible. Table and Figures | Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Disease    2024, 5 (4): 379-380.   DOI: 10.19983/j.issn.2096-8493.2024055 Abstract （166）   HTML （3）    PDF（pc） （762KB）（38）       Knowledge map    Save Reference | Related Articles | Metrics

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Correlation analysis of physical activity levels and symptom clusters in lung cancer chemotherapy patients during hospitalization Chen Xinxin, Liu Guofeng, Yang Yingzi, Hu Yachen, Jin Ying, Li Yumei Journal of Tuberculosis and Lung Disease    2024, 5 (3): 197-206.   DOI: 10.19983/j.issn.2096-8493.2024048 Abstract （165）   HTML （10）    PDF（pc） （746KB）（80）       Knowledge map    Save Objective: Investigate the patients’ willingness to engage in exercise and level of physical activity with patients with lung cancer undergoing chemotherapy, and analyze the correlation between their physical activity level and symptom clusters. Methods: A cross-sectional survey was conducted from June to August 2022 among 232 lung cancer chemotherapy patients hospitalized at the Department of Respiratory Medicine, Shanghai Pulmonary Hospital, using a general questionnaire, the International Physical Activity Questionnaire (IPAQ), the revised version of the lung cancer module of the M.D. Anderson Symptom Inventory (MDASI-LC). A total of 229 valid questionnaires were collected, with an effective recovery rate of 98.71%. Exploratory factor analysis was employed to identify the categories of symptom clusters, and Spearman’s rank correlation analysis was used to examine the correlation between their physical activity level and symptom clusters. Results: Six symptom clusters were identified in patients with lung cancer undergoing chemotherapy: respiratory symptom cluster, sleep-related symptom cluster, psychological symptom cluster, gastrointestinal symptom cluster, lung cancer-specific symptom cluster and cachexia symptom cluster. Moderate-intensity physical activity was negatively associated with psychological and cachexia symptoms (r=-0.153, -0.159; both P<0.05), while walking activity was negatively correlated with respiratory, sleep-related, psychological, and lung cancer-specific symptom clusters (r=-0.257, -0.222, -0.284, -0.181; all P<0.05). Total physical activity level was also negatively correlated with the respiratory, sleep-related, psychological, and cachexia symptom clusters (r=-0.252, -0.218, -0.304, -0.132; all P<0.05). Conclusion: The level of physical activity in lung cancer chemotherapy patients was negatively correlated with symptom clusters, with higher activity levels corresponding to lower symptom burden. It is recommended to design personalized exercise prescriptions, health education, and exercise guidance based on patients’ activity levels and symptom load, aiming to increase physical activity and alleviate symptom burden. Table and Figures | Reference | Related Articles | Metrics

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Meta-analysis of the impact of low-dose CT screening on population lung cancer-specific mortality and all-cause mortality Zi Xiaohui, Wu Peng, Zheng Sufei, Sun Nan, He Jie Journal of Tuberculosis and Lung Disease    2024, 5 (2): 106-112.   DOI: 10.19983/j.issn.2096-8493.2024027 Abstract （164）   HTML （11）    PDF（pc） （1791KB）（42）       Knowledge map    Save Objective: To systematically evaluate the effectiveness of low-dose computed tomography screening (LDCT) in reducing lung cancer-specific mortality and all-cause mortality among screened populations. Methods: A comprehensive search was conducted in databases such as PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Data Knowledge Service Platform for prospective studies on LDCT lung cancer screening, published domestically and internationally from January 2000 to August 2023. Data extraction and quality assessment were performed on studies meeting the inclusion criteria. The primary outcome was lung cancer-specific mortality, while secondary outcomes included all-cause mortality and the number need to be screened (NNBS) to prevent one lung cancer death or death from all causes. Meta-analysis was conducted using R software version 4.3.1. Results: Nine studies with a prospective design were included, covering 123880 individuals screened, aged 40-75 years. The median follow-up time of the studies ranged from 3.6 to 13.0 years. Meta-analysis results showed that compared to non-LDCT screening groups, LDCT screening reduced lung cancer-specific mortality by 16% (RR=0.84, 95%CI: 0.78-0.91, P<0.001). There was no significant difference in the all-cause mortality (RR=0.93, 95%CI: 0.84-1.03, P=0.151). Subgroup analysis indicated that the specific subcategories of the non-LDCT screening group (control group) were related to the reduction in lung cancer mortality. Meta-regression results showed that the median follow-up time was related to the reduction in all-cause mortality. To prevent one death caused by lung cancer through LDCT screening, 139 people were estimated to be screened in the non-imaging prevention/general population; to prevent one death caused by all-cause, 81 people were estimated to be screened. Conclusion: LDCT screening significantly reduces lung cancer-specific mortality in the 40-75 age group, underlining its important public health significance for specific age groups and risk populations. Table and Figures | Reference | Related Articles | Metrics

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Epidemiological characteristics analysis of hospitalized patients with extrapulmonary tuberculosis in Xinjiang Uygur Autonomous Region from 2018 to 2022 Niu Peixuan, A Ertai, Li Yuanyuan, Guan Wenlong, Zheng Tian, Su Dongdong, Du Qingqing, Du Caiyun Journal of Tuberculosis and Lung Disease    2024, 5 (1): 51-57.   DOI: 10.19983/j.issn.2096-8493.2024014 Abstract （162）   HTML （9）    PDF（pc） （840KB）（32）       Knowledge map    Save Objective: To analyze the epidemiological characteristics of hospitalized patients with extrapulmonary tuberculosis in Xinjiang Uygur Autonomous Region from 2018 to 2022. Methods: A retrospective study was conducted to collect the information of 4520 inpatients with extrapulmonary tuberculosis from the medical record system of the Eighth Affiliated Hospital of Xinjiang Medical University from January 1, 2018 to December 31, 2022, including gender, age, nationality, occupation, address, admission diagnosis, cumulative location of the focus, etiology examination results, clinical symptoms, discharge diagnosis, etc. Descriptive analysis was used to analyze the sociodemographic and clinical characteristics, and the risk factors for multiple types of extrapulmonary tuberculosis were analyzed using multivariate logistic regression model. Results: Among the 4520 patients with extrapulmonary tuberculosis, the most patients were admitted in the second quarter (April to June), with a total of 1327cases (29.4%); there were 2844 (62.9%) female patients and 1676 (37.1%) male patients; the number of patients aged 25-34 was the highest (n=1026, 22.7%); the most patients were cadres and staff (n=853, 18.9%); there were 2237 (49.5%) Uyghur patients; 1510 (33.4%) patients were from the southern Xinjiang and 2387 (52.8%) patients were from the northern Xinjiang. Among patients with extrapulmonary tuberculosis, lymph node tuberculosis was the most common, with a total of 1326 (29.3%) cases; 1031 patients (22.8%) had two or more types of extrapulmonary tuberculosis. Multivariate logistic regression analysis showed that, with simple extrapulmonary tuberculosis as a reference, male (OR(95%CI)=1.207 (1.046-1.393)) and fever (OR(95%CI)=1.185 (1.016-1.381)) were risk factors for the combination of multiple extrapulmonary tuberculosis. Conclusion: The proportion of lymph node tuberculosis in extrapulmonary tuberculosis in Xinjiang is the highest, and there are more female patients, more patients were young and middle-aged, and more patients were in southern Xinjiang. In clinical practice, we should focus on early screening and standardized diagnosis and treatment, and extrapulmonary tuberculosis should be included in China’s tuberculosis prevention and control planning and management as soon as possible, and then gradually form a systematic and perfect diagnosis, treatment and prevention system according to local conditions. Table and Figures | Reference | Related Articles | Metrics

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Analysis of treatment outcome and influencing factors of 308 patients with multidrug-resistant pulmonary tuberculosis Xue Jianhang, Cao hong, Li Lu, Liu Xunrui, Ma Guilin, Zheng Rongrong, Ke Ran Journal of Tuberculosis and Lung Disease    2024, 5 (1): 44-50.   DOI: 10.19983/j.issn.2096-8493.20230085 Abstract （160）   HTML （11）    PDF（pc） （1202KB）（56）       Knowledge map    Save Objective: To screen and evaluate the factors affecting treatment outcomes in patients with multidrug-resistant pulmonary tuberculosis (MDR-PTB). Methods: Treatment outcome data of 308 patients with MDR-PTB in Xiamen from 2010 to 2019 were collected through the “Tuberculosis Information Management System”, a subsystem of the “China Disease Prevention and Control Information System”, then risk factors affecting the treatment outcome were analyzed, and the prediction model was built. Results: Of 226 (73.38%) out of these 308 patients were successfully treated. There were 82 cases (26.62%) getting adverse outcomes, including 52 cases (16.88%) with treatment failure, 17 cases (5.52%) died, and 13 cases (4.22%) getting adverse outcome with other causes. Factors influencing the treatment outcome were: male (OR=2.877, 95%CI: 1.356-6.104), age ≥50 years old (OR=1.833, 95%CI: 1.011-3.323), housewife/without a job (OR=0.352, 95%CI: 0.196-0.631), retreatment (OR=6.357, 95%CI: 1.842-21.944), sputum culture negative at 3 month (OR=0.162, 95%CI: 0.063-0.416). The area under ROC curve of the predictive model was 0.909 (95%CI: 0.871-0.938) based on combined predictors to predict the outcome of MDR-TB patients. Conclusion: Male, age ≥50 years old, retreatment patients and sputum culture positive at month 3 were risk factors for adverse outcomes in MDR-PTB patients, housewife/without a job were protective factor for adverse outcomes in MDR-PTB patients. The combined predictor model had fairly strong ability to predict adverse outcomes in patients with MDR-PTB after treatment. Table and Figures | Reference | Related Articles | Metrics

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Analysis of influencing factors on treatment failure in initially treated patients with bacterial positive pulmonary tuberculosis Jiang Ruoxi, Zhong Da, Dou Xiaojie Journal of Tuberculosis and Lung Disease    2024, 5 (3): 236-243.   DOI: 10.19983/j.issn.2096-8493.2024031 Abstract （158）   HTML （9）    PDF（pc） （701KB）（38）       Knowledge map    Save Objective: To analyze the influencing factors of treatment failure in initially treated patients with bacterial positive pulmonary tuberculosis, and provide evidence for improving the treatment success rate. Methods: A retrospective study was conducted to collect the clinical data of 392 new patients with positive bacteria results, who were registered from January to December 2020 in Tianjin Tuberculosis Control Center and completed a one-year follow-up. The data was extracted from Hospital Information System of Tianjin Tuberculosis Control Center. The data included sex, age, marriage, occupation, education level, income, living conditions, smoking and alcohol history, body mass index, basic diseases, symptomatic visits, whether regular physical examination, delayed visits, delayed diagnosis, adverse drug reactions, whether regular drug use, drug resistance of Mycobacterium tuberculosis, and imaging examination results. Single- and multi-variable logistic regression models were used to analyze the factors associated with treatment failure. Results: Among 392 patients, the failure rate of pulmonary tuberculosis treatment was 8.16% (32/392). The multivariate logistic regression analysis showed that the presence of adverse drug reactions (OR=3.109, 95%CI: 1.186-8.151), delayed visits (OR=2.028, 95%CI: 1.742-5.541), delayed diagnosis (OR=3.231, 95%CI: 1.213-8.604), Mycobacterium tuberculosis resistance (OR=8.478, 95%CI: 2.111-34.055), and irregular medication use (OR=1.825, 95%CI: 1.185-2.810) were risk factors for treatment failure, while regular health examinations (OR=0.568, 95%CI: 0.357-0.904) was protective factor for treatment failure in new bacterial positive patients. Conclusion: Improving regular health examinations to detection of potential patients as early as possible, promoting of patients with suspected tuberculosis symptoms to seek medical service and receiving timely diagnosis, carrying out self-management awareness of drug resistance testing, active handling of adverse drug reactions during treatment, strengthening medication safety guidance, guiding patients to improve their own lifestyle habits and medication compliance can all improve the success rate of treatment for new bacterial positive pulmonary tuberculosis patients. Table and Figures | Reference | Related Articles | Metrics

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Analysis of drug resistance status and influencing factors in 203 aged patients with pulmonary tuberculosis combined with type 2 diabetes Ni Nan, Chen Qing, Tang Xianzhen, Zou Liping, Liang Li, Wu Guihui, Mao Li Journal of Tuberculosis and Lung Disease    2024, 5 (1): 28-36.   DOI: 10.19983/j.issn.2096-8493.2024004 Abstract （157）   HTML （11）    PDF（pc） （922KB）（40）       Knowledge map    Save Objective: To explore the characteristics and the related influencing factors of drug resistance in aged pulmonary tuberculosis patients combined with type 2 diabetes. Methods: A retrospective study was conducted to collect the drug sensitivity test results and clinical data of 203 aged pulmonary tuberculosis patients combined with type 2 diabetes who were admitted to Public Health Clinical Center of Chengdu from January 1, 2021 to December 31, 2022 and identified as Mycobacterium tuberculosis with positive sputum culture. The characteristics of drug resistance and the influencing factors of drug resistance were analyzed by univariate and multivariate logistic regression models. Results: In 203 aged pulmonary tuberculosis patients combined with type 2 diabetes, the total drug resistance rate of was 40.4% (82/203), the rate of single drug resistance was 12.3% (25/203), the rate of poly-resistant tuberculosis was 4.9% (10/203) and the rate of multi-drug resistant tuberculosis was 12.8% (26/203). The top three drug resistance rates of 14 anti-tuberculosis drugs were INH (22.7% (46/203))>RFP (15.8% (32/203))>Sm (14.8% (30/203)), and the drug resistance rates of Mfx (11.3% (23/203)) and Lfx (10.8% (22/203)) were higher. Multivariate logistic regression analysis showed that retreatment (OR=4.528, 95%CI: 2.031-10.099, P<0.001), hypoproteinemia (OR=2.106, 95%CI: 1.116-3.972, P=0.021) and CD4+T lymphocyte count <414 cell/μl (OR=1.887, 95%CI: 1.011-3.532, P=0.046) were independent risk factors for drug resistance in aged pulmonary tuberculosis patients combined with type 2 diabetes. Conclusion: The drug resistance rate of aged pulmonary tuberculosis patients combined with type 2 diabetes is high, and the drug resistance is mainly caused by first-line anti-tuberculosis drugs. Drug resistance screening should be actively carried out, and prevention and control measures should be taken as soon as possible for patients with retreatment, hypoproteinemia and CD4+T lymphocyte count <414 cell/μl. Table and Figures | Reference | Related Articles | Metrics

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Research progress of respiratory system injury caused by novel coronavirus Xu Siyun, Lu Nihong Journal of Tuberculosis and Lung Disease    2024, 5 (3): 267-272.   DOI: 10.19983/j.issn.2096-8493.2024041 Abstract （156）   HTML （7）    PDF（pc） （1578KB）（52）       Knowledge map    Save When SARS-CoV-2 infects the respiratory system, it induces a cytokine storm leading to acute inflammation, acute respiratory distress syndrome (ARDS), respiratory failure, and other clinical manifestations, potentially exerting a long-term impact on respiratory health. In severe cases, the infection may lead to pulmonary interstitial fibrosis, resulting in permanent lung damage that profoundly affects individuals’ health and quality of life. The SARS-CoV-2 is in a state of continuous mutation, giving rise to various mutant strains with enhanced transmissibility and virulence. This review primarily consolidates the pathological features, mechanisms, principal clinical manifestations, therapeutic interventions, and prognostic outcomes associated with respiratory system damage caused by SARS-CoV-2 infection. The objective of this review is to enhance the understanding of the respiratory impairments linked to SARS-CoV-2. Table and Figures | Reference | Related Articles | Metrics

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Analysis of the results of pulmonary tuberculosis screening among the elderly in Haizhu District, Guangzhou Cai Xiaoting, Jiang Kunhong, He Liqian, De Hong, Wang Ting, Lai Keng, Wu Xiaoying Journal of Tuberculosis and Lung Disease    2024, 5 (3): 244-248.   DOI: 10.19983/j.issn.2096-8493.2024075 Abstract （152）   HTML （12）    PDF（pc） （680KB）（46）       Knowledge map    Save Objective: To analyze the chest X-ray screening results and the knowledge of core information on tuberculosis among the elderly in Haizhu District, Guangzhou. Methods: From May to July 2022, a questionnaire survey, pulmonary tuberculosis symptom screening, chest X-ray screening, and health education were conducted among the elderly ≥65 years old from 9 districts in Haizhu District. Based on the data obtained from this screening, statistical analysis were conducted. Results: In 2022, a total of 4435 people aged ≥65 years old in Haizhu District, Guangzhou, completed chest X-ray screening and questionnaire. The male-to-female ratio was 0.77∶1 (male 1923,female 2512). The ages ranged from 65 to 102 years old, average age was (72.08±5.48) years old. There were 291 cases of suspected symptoms of pulmonary tuberculosis in the last month, and 490 cases of abnormal chest X-ray results. Among the abnormal chest X-ray cases, 58 cases had suspected symptoms of pulmonary tuberculosis, and 6 cases were finally diagnosed with active pulmonary tuberculosis. The detection rate of pulmonary tuberculosis was 135.29/100000. The total awareness rate of tuberculosis core information among 3633 elderly people was 78.29% (14222/18165), of which the awareness rate of “Pulmonary tuberculosis is a serious chronic infections disease” was the lowest, 56.79% (2063/3633). Conclusion: Tuberculosis screening for the elderly ≥65 years old is helpful for the early detection of elderly pulmonary tuberculosis patients; Tuberculosis publicity and education should continue to be strengthened to increase the awareness rate of tuberculosis core information. Table and Figures | Reference | Related Articles | Metrics

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Meta-analysis of conventional hypoglycemic and anti-tuberculosis therapy combined with thymosin α1 in the treatment of pulmonary tuberculosis complicated with diabetes Li Dan, Zhang Yuhua, Chen Shengyu Journal of Tuberculosis and Lung Disease    2024, 5 (2): 148-157.   DOI: 10.19983/j.issn.2096-8493.2024005 Abstract （148）   HTML （6）    PDF（pc） （5471KB）（23）       Knowledge map    Save Objective: To evaluate the efficacy of conventional hypoglycemic and anti-tuberculosis therapy combined with thymosin α1 in pulmonary tuberculosis patients complicated with diabetes mellitus. Methods: Relevant literature was searched for in both Chinese and English from PubMed, Web of Science, Embase, CNKI, Wanfang Database, etc. from January 1, 2010 to June 30, 2022, with Chinese search terms including thymosin α1, Tα1, tuberculosis, diabetes, and the English search terms including Thymosin alpha 1, Tα1, Tuberculosis, Diabetes mellitus, Diabetes. he results of randomized controlled trial of pulmonary tuberculosis patients complicated with diabetes were collected, all the patients were treated with conventional hypoglycemic and anti-tuberculosis therapy combined with thymosin α1. Results: A total of 1117 references were retrieved, and 13 were ultimately included in the study; the 685 included patients were divided into the observation group (n=335, combined with thymosin α1) and the control group (n=350, conventional hypoglycemic and anti-tuberculosis treatment). Meta analysis showed that, of the observation group, the treatment efficacy rate (OR (95%CI)=4.08 (2.77-6.02)), sputum negative conversion rate (OR (95%CI)=4.61 (3.21-6.63)), and lesion absorption rate (OR (95%CI)=5.06 (3.19-8.04)) were significantly better than those of the control group; the CD4+T cell levels after treatment (standardized mean difference (SMD)=2.07, 95%CI: 1.37-2.77, P<0.001) and CD3+T cell levels (SMD (95%CI)=2.33 (0.98-3.67), P=0.001) were significantly better than those in the control group; after treatment, the CD8+T cell level was significantly lower than that in the control group (SMD (95%CI)=-2.21 (-2.95--1.48), P<0.001), and the CD4+/CD8+ ratio was significantly increased (SMD (95%CI)=1.25 (0.73-1.77), P<0.001). Conclusion: Conventional hypoglycemic and anti-tuberculosis combination with thymosin α1 treatment for pulmonary tuberculosis patients complicated with diabetes could improve the treatment efficiency, focus absorption rate and sputum negative conversion rate; with the treatment, the patient’s CD4+, CD3+T cell levels, and CD4+/CD8+ratio have all increased. Table and Figures | Reference | Related Articles | Metrics

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Analysis of the epidemic characteristics of pulmonary tuberculosis in Qingdao from 2008 to 2022 Sun Haiyan, Dai Xiaoqi, Song Song, Chen Meng, Xu Honghong, Wang Zhongdong, Zhang Huaqiang Journal of Tuberculosis and Lung Disease    2024, 5 (2): 164-167.   DOI: 10.19983/j.issn.2096-8493.2024015 Abstract （146）   HTML （9）    PDF（pc） （740KB）（35）       Knowledge map    Save Objective: To analyze the epidemiological characteristics of pulmonary tuberculosis in Qingdao from 2008 to 2022. Methods: A total of 38507 pulmonary tuberculosis patients registered in Qingdao from January 1, 2008 to December 31, 2022 were collected through the “Disease Surveillance Information System”,and then the epidemic characteristics of pulmonary tuberculosis were analyzed. Results: From 2008 to 2022, 38507 cases of pulmonary were totally reported in Qingdao. The average reported incidence rate was 27.63/100000, with an average annual decline rate of 3%. The highest incidence rate was reported in 2008 (33.66/100000), and the lowest incidence rate was reported in 2022 (20.78/100000). (1) Time distribution: the number of reported cases showed a clear temporal pattern from 2008 to 2019, with a higher number of reported cases from March to August each year, accounting for 55.16% (17539/31798); November and January to February were the lowest reported incidence periods, accounting for 20.46% (6505/31798). (2) Regional distribution: from 2008 to 2022, the average reported incidence rate of active pulmonary tuberculosis was the highest in Licang District (50.09/105, 3622 cases), and the lowest was in Shinan District (20.70/100000, 1719 cases). (3) Population distribution: the reported incidence rate of male was 52.97/100000 (26959 cases), which was higher than that of female (13.05/100000, 11548 cases); the age group of 20-29 years old had the highest proportion of patients (25.81%, 9940/38507), and the proportion of people who work as “farmers” was the highest (40.59%, 15631/38507). Conclusion: The reported incidence of pulmonary tuberculosis in Qingdao showed a decreasing trend from 2008 to 2022. Prevention and control in key areas and populations should be further strengthened. Table and Figures | Reference | Related Articles | Metrics

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The correlation between symptom burden and quality of life in patients with chronic obstructive pulmonary disease Zheng Xiaoxia, Zhu Xiaoxiao, Wu Yifan, Gu Fen Journal of Tuberculosis and Lung Disease    2024, 5 (3): 207-211.   DOI: 10.19983/j.issn.2096-8493.2024034 Abstract （143）   HTML （10）    PDF（pc） （681KB）（26）       Knowledge map    Save Objective: To investigate the correlation between symptom burden and quality of life in chronic obstructive pulmonary disease (COPD) patients. Methods: Totally 116 COPD patients from the First Hospital Affiliated with Ningbo University were selected by convenience sampling method. A general situation questionnaire, Chinese version of memory symptom assessment scale and COPD assessment test (CAT) scale were used to survey them. Results: Among the symptoms of COPD patients, the prevalence (81.03%, 94/116), frequency (51.72%, 60/116), severity (41.38%, 48/116), and bothersome (39.66%, 46/116) of shortness of breath all ranked the first. In the symptom burden score, the median score of psychological symptom distress score was the highest at 0.58 (0.00, 1.28); the total score of quality of life was significantly positively correlated with the total symptom burden score, physical symptom distress score, psychological symptom distress score, and global distress index (r=0.66, r=0.52, r=0.61, r=0.58, all P<0.05). Conclusion: In clinical practice, attention should be paid to the dyspnea symptoms of patients with COPD. The higher the symptom burden, the worse the quality of life. Healthcare professionals should strengthen the assessment of symptom burden in COPD patients, especially psychological symptom burden, take targeted intervention measures to reduce the symptom burden of COPD patients and improve their quality of life. Table and Figures | Reference | Related Articles | Metrics

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Exploring the causes of recurrence and genetic characteristics of tuberculosis strains in Beijing based on genotypic analysis Zhang Jie, Ding Beichuan, Ren Yixuan, Tian Lili, Yi Junli, Pang Mengdi, Yang Xinyu Journal of Tuberculosis and Lung Disease    2024, 5 (2): 128-134.   DOI: 10.19983/j.issn.2096-8493.2024018 Abstract （142）   HTML （4）    PDF（pc） （3537KB）（40）       Knowledge map    Save Objective: To investigate the causes of recurrence in tuberculosis patients in Beijing and the genetic characteristics of their strains, aiming to provide a scientific basis for the effective prevention and treatment of recurrent tuberculosis patients. Methods: The RD105 gene deletion method and 15-locus variable number tandem repeat genotyping experiment (VNTR) were used to compare the genotypes of Mycobacterium tuberculosis (MTB) of the initial and recurrent episodes in pulmonary tuberculosis patients in Beijing from January 2017 to December 2019, to elucidate the etiology of recurrent tuberculosis. The final isolates from recurrent patients were selected to evaluate the discriminatory ability of the genotyping technology on MTB strains of Beijing. Furthermore, a phylogenetic analysis was conducted to investigate the genetic characteristics of MTB prevalent in recurrent patients, providing insights into the evolutionary relationships within the strains associated with recurrent tuberculosis cases in Beijing. Results: The proportion of endogenous reactivation among recurrent patients was 65.4% (51/78), while the proportion of exogenous reinfection was 34.6% (27/78). Among the 78 MTB isolates obtained from recurrent patients, 71 were Beijing genotype, and 7 were non-Beijing genotype. 78 strains exhibited 68 distinct genotypes. Within 2 clonal complex clusters, 13 isolates formed 4 clusters, while among 24 unique strains, 2 isolates formed 1 cluster, resulting in a clustering rate of 12.8%. The hunter-gaston discrimination index for all MTB strains across the 15 VNTR loci was 0.994. Conclusion: The primary cause of recurrent tuberculosis in Beijing was endogenous reactivation, with a relatively low clustering rate. The predominant strain was Beijing genotype, exhibiting a high degree of genetic diversity. Table and Figures | Reference | Related Articles | Metrics

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Analysis of patient delay and its influencing factors among elderly pulmonary tuberculosis patients in Tongzhou District of Beijing, 2016—2022 Yang Chao, Wang Jing, Tang Guilin, Gao Hanqing, Wang Bin Journal of Tuberculosis and Lung Disease    2024, 5 (1): 58-63.   DOI: 10.19983/j.issn.2096-8493.2024010 Abstract （142）   HTML （12）    PDF（pc） （833KB）（44）       Knowledge map    Save Objective: To analyze the current situation and influencing factors of patient delay among elderly (≥60 years old) pulmonary tuberculosis (PTB) in Tongzhou District of Beijing from 2016 to 2022, and to provide scientific basis for reducing the patient delay in the future. Methods: Data of 963 cases of PTB patients in the elderly people in Tongzhou District of Beijing from 2016 to 2022 were extracted from the Tuberculosis Management Information System of China Information System for Disease Control and Prevention, including medical records, diagnosis and treatment information, and so on. Descriptive statistics was used to analyze the distribution and trend of patient delay. Influencing factors of patient delay was analyzed by multivariable logistic regression. Results: From 2016 to 2022, the median and quartile of patient delay days was 5 (0,32) days. The average patient delay rate was 40.08% (386/963). The median of patient delay days went down from 12 (0,37) days in 2016 to 0 (0,24) days in 2022. The patient delay rate changed from 34.39% (54/157) in 2016 to 50.42% (60/119) in 2019, showing a upward trend ( {\chi }_{\mathrm{t}\mathrm{r}\mathrm{e}\mathrm{n}\mathrm{d}}^2=7.605,P=0.006), and then decreased to 30.99% (44/142) in 2022, showing a downward trend ( {\chi }_{\mathrm{t}\mathrm{r}\mathrm{e}\mathrm{n}\mathrm{d}}^2=7.138,P=0.008). Multivariable logistic regression analysis showed that patient registered during 2020—2022 (OR=0.667,95%CI:0.508-0.876) was the protective factor for patient delay. Non-urban area (OR=1.368,95%CI:1.037-1.804) was the risk factor for patient delay. Conclusion: The patient delay showed an upward-then-downward trend from 2016 to 2022. The patient delay was related to year of registration and current address. It is necessary to perform targeted intervention measures. Table and Figures | Reference | Related Articles | Metrics

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Analysis of risk factors and construction of risk prediction model for anemia in patients with chronic obstructive pulmonary disease Fu Yiting, Liu Lei, Zhao Qian, Meng Jixian, Zhen Ziyi, Wang Yang, Li Rongmei Journal of Tuberculosis and Lung Disease    2024, 5 (1): 20-27.   DOI: 10.19983/j.issn.2096-8493.2024003 Abstract （141）   HTML （8）    PDF（pc） （1650KB）（82）       Knowledge map    Save Objective: To explore the risk factors of anemia in patients with chronic obstructive pulmonary disease (COPD), and construct a nomograph prediction model. Methods: COPD patients admitted to the Respiratory Department of the Second Affiliated Hospital of Shenyang Medical College from December 2019 to March 2023 were retrospectively selected as the study objects (492 patients). LASSO regression was used to screen risk factors, and logistic regression analysis was used to construct a prediction model of anemia in COPD patients, and a nomogram prediction model was constructed. The model was validated internally by Bootstrap resample method. The calibration curve and its C-index were used to evaluate the differentiation of the model. The area under receiver operating characteristic (ROC) curve and clinical decision curve (DCA) were used to evaluate the prediction ability and clinical applicability of the nomogram prediction model, respectively. Results: A total of 492 COPD patients were included, 19.51% (96/492) of them had anemia. Nine candidate predictors were identified by LASSO regression analysis: gender, creatinine, hypoproteinemia, diabetes, hypertension, COVID-19 infection, red blood cells (RBC), hemoglobin (Hb), body mass index (BMI). They were included in logistic regression analysis, and the results showed that gender being female (OR=3.353, 95%CI: 1.530-7.349), elevated creatinine levels (OR=1.024, 95%CI: 1.010-1.037), elevated Hb levels (OR=0.928, 95%CI: 0.905-0.951), hypoproteinemia (OR=6.239, 95%CI: 2.845-13.678), diabetes mellitus (OR=0.198, 95%CI: 0.056-0.703) were all independent influencing factors for anemia. Calibration curve of the nomogram prediction model showed good fitness, with a C-index of 0.933 (95%CI: 0.910-1.848), indicating that the model was well distinguished. The area under the curve was 0.933 (95%CI: 0.910-0.957), and DCA curve showed good clinical applicability of the model. Conclusion: The prediction model of COPD combined with anemia is simple and accurate, has certain value in early clinical screening of high-risk groups of anemia and the formulation of individualized precise prevention and treatment plans. Table and Figures | Reference | Related Articles | Metrics

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Research of symptom groups of chronic obstructive pulmonary disease and their correlation with patient’s quality of life Qiu Qiaojing, Tao Yang, Shen Jiani, Xu Jiapin, Zhu Lihong, Gu Fen Journal of Tuberculosis and Lung Disease    2024, 5 (3): 219-224.   DOI: 10.19983/j.issn.2096-8493.2024067 Abstract （137）   HTML （7）    PDF（pc） （700KB）（25）       Knowledge map    Save Objective: To explore the composition of symptom groups at different stages of chronic obstructive pulmonary disease (COPD) patients, the interrelationships between symptom groups, and the correlation between symptom groups and patient’s quality of life. Methods: Convenience sampling was used to select 223 COPD patients who were hospitalized from November 2022 to November 2023 in Department of Respiratory and Critical Care Medicine, Ningbo University Affiliated to People’s Hospital. A patient basic information questionnaire, memorial symptom assessment scale (MSAS), and COPD assessment test (CAT) were used to evaluate symptoms, breathing difficulties, and emotions of the patients on the first day of hospitalization (T1, disease exacerbation phase), the day before or on the day of discharge (T2), and one month (T3) and three months (T4) after discharge(disease stable phase). Statistical description, factor analysis, and cluster analysis were used to analyze the symptoms and evaluate their impact on the patient’s quality of life. Results: The average numbers of symptoms in COPD patients between T1 and T4 were 29 (26, 31), 25 (22, 28), 27 (25, 29), and 29 (27, 31), respectively. There were three different symptom groups at four time points: respiratory perception related symptom group, psychological perception related symptom group, and gastrointestinal perception related symptom group. The average total scores of CAT scales for COPD patients between T1 and T4 were 29.13±6.37, 20.31±6.47, 18.68±6.27, and 20.31±6.47, respectively, variance analysis showed that the difference was statistically significant (F=126.284, P<0.001). The correlation analysis between three symptom groups and patient’s quality of life showed that except for gastrointestinal perception related symptom group at T4 which was not correlated with the total score of CAT (r=0.009,P>0.05), all other symptom groups were positively correlated with the total score of CAT (Ps<0.05). Conclusion: COPD patients experience different symptoms during the acute and stable phases of the disease, with symptoms clustering in three forms and worsening. The more severe the distress on the patient, the greater the impact on their quality of life. Table and Figures | Reference | Related Articles | Metrics

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Application of LungPoint navigation combined with indocyanine green fluorescence imaging in lymph node sampling of stage Ⅰa non-small cell lung cancer Zhu Jiankun, Liu Dawei, Li Xiaofeng, Meng Qian Journal of Tuberculosis and Lung Disease    2024, 5 (2): 101-105.   DOI: 10.19983/j.issn.2096-8493.2024029 Abstract （136）   HTML （6）    PDF（pc） （815KB）（30）       Knowledge map    Save Objective: To find a method to accurately locate sentinel lymph nodes (SLN) in patients with stage Ⅰa non-small cell lung cancer (NSCLC) and to verify the rationality of SLN as a lymph node sample. Methods: A prospective study was conducted to include 50 patients with stage Ⅰa NSCLC in the Thoracic Surgery Department of Shandong Provincial Public Health Clinical Center from January 2021 to December 2023 according to the enrollment criteria. The tracer indocyanine green was injected around the tumor by LungPoint navigation tracheoscopy before surgery, and SLN localization was completed by fluorescence thoracoscopic imaging. The pathological examination of regional lymph nodes including SLN was performed, and the recognition rate, accuracy rate and false negative rate of SLN were used to verify the rationality of the method as a lymph node sampling sample. Results: Among the 50 patients, SLN was detected in 41 cases, with a recognition rate of 82.0% (41/50), of which 3 patients were detected with lymph node metastasis (SLN positive), a total of 9 lymph nodes, and 1 patient also detected 2 positive non-sentinel lymph nodes (N-SLN). In 9 patients, no SLN was detected, 54 lymph nodes were dissected, and no metastatic lymph nodes were found, so the accuracy rate of SLN was 100.0% (41/41) and the false negative rate was 0 (0/3). Conclusion: With the help of LungPoint tracheoscopy to inject the tracer indocyanine green around the tumor, the SLN technology explored by fluorescence thoracoscopic imaging has a high predictability of regional lymph node metastasis, which is expected to be the basis for guiding the systematic lymph node sampling of stage Ⅰa NSCLC. Table and Figures | Reference | Related Articles | Metrics

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Evaluation of next generation sequencing for the diagnosis of osteoarticular tuberculosis infection Yao Xiaowei, Liu Shuren, Jing Yanse, Jia Chenguang Journal of Tuberculosis and Lung Disease    2024, 5 (1): 37-43.   DOI: 10.19983/j.issn.2096-8493.20230094 Abstract （132）   HTML （8）    PDF（pc） （1028KB）（37）       Knowledge map    Save Objective: To evaluate the application value of next generation sequencing (NGS) technology in the diagnosis of osteoarticular tuberculosis. Methods: A retrospective study method was used to collect the clinical data of 185 patients with suspected osteoarticular tuberculosis admitted to the Department of Orthopedics of Hebei Provincial Chest Hospital from Dec 2019 to Dec 2022 with reference to the enrollment criteria. The patients were categorized into the tuberculosis group (osteoarticular tuberculosis, 155 cases) and the non-tuberculosis group (non-osteoarticular tuberculosis, 30 cases) according to the final clinical diagnosis. All patients’ lesion specimens were obtained during surgery or puncture (including 51 pus, 89 granulation tissue and 45 bone tissue specimens), and all of them were sent for NGS, BACTEC MGIT 960 mycobacterial liquid culture (culture), and rifampicin resistance real-time fluorescence quantitative nucleic acid amplification assay (GeneXpert MTB/RIF, Xpert). The final clinical diagnosis was used as the reference standard to compare the efficacy of the three methods in the diagnosis of osteoarticular tuberculosis, and to analyze the positivity of the three methods in the detection of pus, granulation tissue and bone tissue specimens. Results: Of the 185 patients with suspected bony joint tuberculosis, the positive rate of NGS for detecting osteoarticular tuberculosis (63.24%, 117/185) was significantly higher than that of Xpert (54.05%, 100/185) and culture (35.68%, 66/185), and the differences were statistically significant (χ2=24.982, P<0.001; χ2=37.934, P<0.001). Using the final clinical diagnosis as the reference standard, the sensitivity of NGS, Xpert and culture methods for the diagnosis of osteoarticular tuberculosis were 74.84% (116/155), 64.52% (100/155) and 42.58% (66/155), respectively, and the specificity were 96.67% (29/30), 100.00% (30/30) and 100.00% (30/30), the diagnostic compliance rates were 78.38% (145/185), 70.27% (130/185) and 51.89% (96/185), respectively, and the Kappa values were 0.799, 0.590 and 0.504, respectively, and the AUC (95%CI) values were 0.867 (0.693-0.941), 0.703 (0.612-0.784) and 0.623 (0.529-0.717), respectively. The positive rates of pus detected by NGS was 80.39% (41/51), respectively, which were significantly higher than that granulation (62.92% (56/89)) and bone tissue specimens (44.44% (20/45)), and the differences were all statistically significant (χ2=4.560, P=0.031; χ2=13.335, P<0.001). Conclusion: NGS technology can significantly increase the pathogenetically positive detection rate in patients with osteoarticular tuberculosis with high detection efficacy, and has the highest diagnostic value with pus specimens. Table and Figures | Reference | Related Articles | Metrics

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Effect of early limb active exercise on incidence of pulmonary embolism among patients received lung cancer surgery Pan Qiong, Tian Yayuan, Tong Fei Journal of Tuberculosis and Lung Disease    2024, 5 (3): 212-218.   DOI: 10.19983/j.issn.2096-8493.2024061 Abstract （131）   HTML （5）    PDF（pc） （711KB）（26）       Knowledge map    Save Objective: To analyze the effect of early active limb movement in reducing postoperative pulmonary embolism (PE) in lung cancer patients. Methods: Using retrospective research method, according to enrolment criteria, 187 patients who had received surgical treatment of lung cancer in Shanghai Ninth People’s Hospital affiliated to Shanghai Jiaotong University School of Medicine from January to December 2019 were selected as control group, and 194 patients treated from January to December 2020 were selected as observation group. The control group was given routine nursing, while the observation group took early active limb activity on top of routine nursing. We compared the levels of platelet indicators (PLT, PDW, MPV) and fibrinolytic indicators (PAI-1, tPA, D-dimer) between the two groups of patients on postoperative day 1 and 7, as well as the incidence of PE within 1 and 7 days, the survival of patients in 7-day, 1-month, 6-month, 1-year, and 3-year periods after surgery. Results: The incidence of MPV ((7.29±0.51) fl and (7.22±0.82) fl), PLT ((173.13±21.56)×109/L and (169.11±19.64)×109/L), PAI-1 ((6.61±0.80) AU/ml and (6.53±1.21) AU/ml), tPA ((0.81±0.21) IU/ml and (0.82±0.11) IU/ml) on day 1 and day 7, and D-dimer ((0.31±0.11) mg/L) on day 1, as well as the incidence of PE (2.58% (5/194)) on day 7 were lower in the observation group than in the control group ((8.23±0.69) fl and (8.11±1.13) fl, (184.56±23.71)×109/L and (181.61±21.78)×109/L, (7.41±1.22) AU/ml and (7.32±1.11) AU/ml, (0.92±0.21) IU/ml and (0.91±0.41) IU/ml, (0.41±0.11) mg/L, and 9.63% (18/187)), whereas the survival rates (85.57% (166/194) and 63.40% (123/194)) at 1 and 3 years after surgery were significantly higher than those of the control group (70.05% (131/187) and 51.87% (97/187)), and the differences were statistically significant in all cases (t=18.294, P=0.043; t=15.011, P=0.039; t=20.415, P=0.048; t=19.669, P=0.046; t=18.214, P=0.028; t=19.015, P=0.032; t=17.141, P=0.033; t=18.011, P=0.039; t=15.326, P=0.049; χ2=8.195,P=0.019; χ2=5.148, P=0.031; χ2=7.047, P=0.007). No patient developed PE on postoperative day 1 in either group, and there were no deaths within 7 days or 1 month. Conclusion: Early active limb activity program can reduce the incidence of postoperative PE in patients with lung cancer, improve the prognosis of patients and prolong the survival period, which is worthy of promotion and application. Table and Figures | Reference | Related Articles | Metrics

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Research progress on immune cells in chronic obstructive pulmonary disease complicated with cardiovascular disease Peng Maocuo, Xie Jungang Journal of Tuberculosis and Lung Disease    2024, 5 (2): 179-185.   DOI: 10.19983/j.issn.2096-8493.20230118 Abstract （128）   HTML （9）    PDF（pc） （785KB）（23）       Knowledge map    Save In addition to impaired lung structure and function, chronic obstructive pulmonary disease (COPD) has the release of local inflammatory mediators into circulation system which would induce a systemic inflammatory response. The systemic inflammatory response can further cause or exacerbate extra-pulmonary comorbidities of COPD, such as cardiovascular disease (CVD), osteoporosis, anxiety and depression, and infections, with CVD being particularly commonly observed in clinical practice. Patients with COPD are at an increased risk of CVD, and co-morbid CVD can lead to decreased quality of life, re-hospitalization, and a worse long term prognosis. COPD and CVD are the greatest global disease burden, and they both have immune cell malfunction. Therefore, knowing the common mechanisms of these two diseases could contribute to a comprehensive understanding and appropriate management of them, thereby alleviating the burden of disease. The authors provides an overview of the immune mechanisms of COPD and CVD. Reference | Related Articles | Metrics

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Construction of a new system of school tuberculosis prevention and control strategy using Delphi evaluation method Lin Ying, Lei Yu, Zhong Miner, Du Yuhua Journal of Tuberculosis and Lung Disease    2024, 5 (2): 120-127.   DOI: 10.19983/j.issn.2096-8493.2024035 Abstract （124）   HTML （7）    PDF（pc） （838KB）（46）       Knowledge map    Save Objective: To construct a new system of school tuberculosis prevention and control strategy by using Delphi evaluation method. Methods: Based on the national school tuberculosis prevention and control guidelines, as well as relevant literature on school tuberculosis prevention and control strategies in Wanfang Data, China Network Knowledge Infrastructure and other databases, and in combination with the current situation of tuberculosis prevalence in schools in Guangzhou, the implementation of preventive and control measures in schools, and the follow-up visits of cases and close contacts, the Guangzhou Institute of Tuberculosis Prevention and Treatment formulated a preliminary framework of school tuberculosis prevention and control strategy system, which involves 58 strategies in four major categories. Twenty-one experts across the country were organized to conduct two rounds of consultation on strategies. A new system of school tuberculosis prevention and control strategies and the weighting of the strategies was established based on the importance and feasibility of the selected strategies by using indicators such as expert positive index, expert authority coefficient (Cr);including degree of familiarity (Cs) and judgment basis (Ca), degree of concentration of experts’ opinions (including frequency range of full importance scores, frequency range of full feasibility scores, mean of composite scores and coefficient of variation (CV), degree of coordination of experts’ opinions (Kendall’s coordination coefficient), and coefficient of weighting of the strategies, etc. Results: The expert positivity index in both rounds of consultation was 100.0% (21/21), and the Cs, Ca, Cr, frequency range of full importance scores, frequency range of full feasibility scores, mean of composite scores and CV ranges in the first round of expert consultation were 0.83±0.11, 0.95±0.07, 0.90±0.07, 5.36% to 98.28%, 1.79% to 96.85%, 4.36±0.75, 0.05 to 0.20, respectively, and the Kendall coordination coefficients of the strategies was 0.343 (χ2=484.79, P=0.000); the results of the second round of expert consultation were 0.85±0.09, 0.94±0.08, 0.90±0.07, 8.62% to 97.83%, 6.52% to 95.53%, 4.51±0.60, 0.02 to 0.16, and 0.433 (χ2=315.24, P=0.000), respectively. Experts’ opinions were highly concentrated, and finally a new school tuberculosis prevention and control strategy system including 3 primary strategies, 7 secondary strategies and 25 tertiary strategies was established, as well as the weight of each strategy. Conclusion: The Delphi evaluation method was used to construct a new school tuberculosis prevention and control strategy system, and a new school tuberculosis prevention and control strategy suitable for the region was initially established, providing a scientific reference for promoting the precise prevention and control of schools tuberculosis. Table and Figures | Reference | Related Articles | Metrics

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Application effect and safety analysis of a sputum splash prevention device Zhu Xiaoxiao, Tian Yayuan, Wang Pengfei, Huang Jiali, Gu Fen Journal of Tuberculosis and Lung Disease    2024, 5 (3): 225-229.   DOI: 10.19983/j.issn.2096-8493.2024051 Abstract （119）   HTML （7）    PDF（pc） （867KB）（16）       Knowledge map    Save Objective: To analyze the effect and safety of a device for preventing sputum splashing in reducing sputum splash contamination patients undergoing tracheotomy. Methods: Fifty-four patients who were prepared to undergo tracheotomy in the Intensive Care Unit of the General Surgery Department of the Ninth People’s Hospital affiliated to Shanghai Jiaotong University School of Medicine from April to December 2023 were selected as research objects. A convenient sampling method was used to include those with odd-numbered of medical records were included in observation group (wearing the new sputum splash prevention device) and those with even-numbered medical records were included in the control group (wearing the self-made simple plastic bottle sputum splash prevention device), 27 cases in each group. The sputum splash, blood oxygen saturation, partial pressure of carbon dioxide, and incidence of pulmonary infection were compared between the two groups before and after wearing the device. Results: In the observation group, no patient splashed sputum into the surrounding environment after using the new device, and no patient had pulmonary infection after 1 month of using the device, while in the control group, sputum flowed along the wall of the cup, and 4 patients (14.8%) had lung infection after 1 month of using the device. The mean oxygen saturation before and after using the device in the control group were (96.42±4.93) % and (97.01±3.40) %, and the partial pressures of carbon dioxide were (39.88±7.64) mmHg and (38.13±8.09) mmHg, while in the observation group before and after the use of the new device, the mean oxygen saturation were (97.43±3.73) % and (98.33±1.40) %, and the partial pressures of carbon dioxide were (38.14±9.05) mmHg and (42.05±7.89) mmHg. None of the differences were statistically significant (t=-1.329,P=0.197;t=0.476,P=0.638;t=1.965,P=0.060;t=-1.284,P=0.212). Conclusion: The new device for preventing sputum splash is simple to operate, and the avoidance of sputum splash after wearing is better than the self-made simple plastic bottle device, which effectively prevents lung infection and does not affect the patient’s oxygen saturation and carbon dioxide partial pressure. The new device for preventing sputum splash can be used for patients who are taken off the machine after tracheotomy in the intensive care unit, and it can be widely used in clinical practice. Table and Figures | Reference | Related Articles | Metrics

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Epidemiological characteristics of pulmonary tuberculosis in Taicang City from 2017 to 2022 Zhang Taifa, Zhou Hua Journal of Tuberculosis and Lung Disease    2024, 5 (1): 64-69.   DOI: 10.19983/j.issn.2096-8493.20230125 Abstract （117）   HTML （9）    PDF（pc） （836KB）（55）       Knowledge map    Save Objective: To analyze the epidemiological characteristics of pulmonary tuberculosis (PTB) in Taicang City from 2017 to 2022, and to provide direction and basis for PTB prevention and control. Methods: Medical records of 1444 PTB patients registered in the “Tuberculosis Management Information System”, a subsystem of the “China Disease Prevention and Control Information System” in Taicang City from 2017 to 2022 were extracted, and then the morbidity characteristics of those patients were described, and the distribution characteristics about time, area, people were analyzed. Results: A total of 1444 patients with active PTB were registered in Taicang City from 2017 to 2022, among which 676 were etiologically positive, accounting for 46.81%, with an average registration rate of 30.92/100000 (1444/4669900), changed from 34.79/100000 (249/715800) in 2017 to 22.88/100000 (193/843600) in 2022, showing a downward trend ( {\chi }_{\mathrm{t}\mathrm{r}\mathrm{e}\mathrm{n}\mathrm{d}}^2=35.942, P=0.001). The average registration rate in 2020—2022 was 26.10/100000 (656/2513700), lower than that in 2017—2019 (36.55/100000, 788/2156200), and the difference was statistically significant (χ2=13.662, P=0.001). The top three towns in terms of the number of patients were Chengxiang Town (332 cases, 22.99%), High-tech Zone (303 cases, 20.98%) and Fuqiao Town (225 cases, 15.58%), and the lowest was Huangjing Town (125 cases, 8.66%). The number of male patients (1023 cases, 70.84%) was higher than that of female patients (421 cases, 29.16%). The peak age of disease onset was concentrated between 25—34 years old (350 cases, 24.24%). The occupation with the highest number of cases was farmers (534 cases, 36.98%). Conclusion: The tuberculosis registration rate in Taicang City showed a downward trend from 2017 to 2022. In the future work, attention should be paid to key towns and key groups to strengthen publicity and education, improve the diagnosis level, and improve the management and treatment system. Table and Figures | Reference | Related Articles | Metrics

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Metagenomic next-generation sequencing assisted in the diagnosis of psittacosis: a case report and literature review Yuan Yonglong, Li Huimei, Ma Dedong Journal of Tuberculosis and Lung Disease    2024, 5 (2): 113-119.   DOI: 10.19983/j.issn.2096-8493.2024016 Abstract （115）   HTML （6）    PDF（pc） （1020KB）（40）       Knowledge map    Save Objective: To investigate the clinical features, epidemiological features, diagnosis, treatment and prognosis of psittacosis. Methods: A case of Chlamydia psittaci pneumonia admitted to the Pulmonary and Critical Care Medicine of Shandong Provincial Qianfoshan Hospital was retrospectively reviewed. The diagnosis and treatment was analyzed. Using “Psittacosis” as search terms, relevant literature was searched from the PubMed, Wanfang, WIP, CNKI databases and then analyzed. Results: The patient was 52-year-old, male, had a history of hypertension, and admitted to the hospital due to “fever and cough for 20 days”. He had been treated with moxifloxacin and cefoperazone-sulbactam before admission, but the condition did not improve. Psittacosis pneumonia was confirmed by detecting Chlamydia psittaci in the bronchoalveolar lavage fluid using metagenomic next-generation sequencing after that the patient was transferred to our department. The patient improved after treatment with levofloxacin combined with minocycline and was discharged from the hospital. Through literature review, it was found that psittacosis is a zoonotic disease that can affect multiple systems in the body, with the respiratory system being affected most commonly. This disease can be transmitted between humans. Metagenomic high-throughput sequencing technology has more advantages than traditional detection methods such as serology, pathogen isolation and culture, and polymerase chain reaction. Tetracycline drugs are the preferred treatment with a duration of 2-3 weeks. The prognosis of this disease is generally good, with an overall mortality rate of approximately 1%. Conclusion: Psittacosis is a zoonotic disease that requires early treatment. Because of lack of specificity of the clinical characteristics and examination results, the rates of misdiagnosis and missed diagnosis are high. Metagenomic high-throughput sequencing technology has advantages in diagnosing this disease. Tetracycline drugs are the preferred treatment with good prognosis in general. Table and Figures | Reference | Related Articles | Metrics

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Research progress on the concept discrimination and treatment of type 2 inflammation in asthma Shi Xu, Chen Ruchong, Li Jing Journal of Tuberculosis and Lung Disease    2024, 5 (5): 489-494.   DOI: 10.19983/j.issn.2096-8493.2024107 Abstract （114）   HTML （6）    PDF（pc） （1778KB）（46）       Knowledge map    Save Bronchial asthma (asthma) is a heterogeneous disease with multiple phenotypes based on differences in clinical features, triggers, airway inflammation, physiological and pathological features. The Global Initiative for Asthma (GINA) guidelines suggest that type 2 inflammation exists in asthma and can be diagnosed by testing for eosinophils, exhaled nitric oxide, and allergens. It has been found that 50% to 70% of asthma patients are related to type 2 inflammation, and the proportion of type 2 inflammation in severe asthma patients in China is more than 75%. Therefore, drug development and treatment for type 2 inflammation are critical. The authors review the concept, classification, pathogenesis, biomarkers and judgment criteria, asthma and the research progress of targeted therapy of type 2 inflammatory, and provides reference for the diagnostic and treatment of asthma biologics. Table and Figures | Reference | Related Articles | Metrics

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Multidimensional differential diagnosis of pulmonary tuberculosis and pulmonary sarcoidosis accompanied by granulomatous inflammation of pulmonary tissue Sha Min, Zhu Weidong, Jin Yifan, Lyu Leilei, Chen Cheng Journal of Tuberculosis and Lung Disease    2024, 5 (2): 135-142.   DOI: 10.19983/j.issn.2096-8493.2024026 Abstract （111）   HTML （12）    PDF（pc） （2376KB）（24）       Knowledge map    Save Objective: To analyze the clinical features of pulmonary tuberculosis and pulmonary sarcoidosis complicated with granulomatous inflammation of pulmonary tissue, in order to build a differential diagnostic model of the two groups. Methods: A retrospective study was conducted in 121 patients with pulmonary granulomatosis diagnosed by bronchoscopic lung tissue biopsy in the First Affiliated Hospital of Soochow University from January 2016 to December 2022. Among them, there were 34 cases of pulmonary sarcoidosis and 87 cases of tuberculosis. Demographic data, clinical symptoms, chest CT imaging data, histopathology, bronchoscopic data were collected, and the independent predictors of the two groups were screened out by logistic regression analysis. Finally, established the disease diagnosis model, and evaluated the differential diagnosis efficiency of the model. Results: Logistic regression analysis showed that male (OR=5.51, 95%CI: 1.67-18.17), nodule diameter ranged from 1 cm to 3 cm (OR=5.82, 95%CI: 1.47-23.08), segmental bronchial stenosis (OR=6.43, 95%CI: 1.59-25.92), bilateral lung involvement (OR=0.03, 95%CI: 0.00-0.16) were independent predictors of tuberculosis and pulmonary sarcoidosis. Accordingly, the disease diagnosis model was established with the AUC of 0.884 (95%CI: 0.819-0.949). The specificity was 79.4%, and the sensitivity was 86.2%. Conclusion: There are differences in patient gender, lung lesion size, morphology, and other aspects between pulmonary tuberculosis and pulmonary sarcoidosis with granulomatous inflammation of lung tissue. The diagnostic model can be better used for the differential diagnosis of the two groups. Table and Figures | Reference | Related Articles | Metrics

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Progress in the expression of long-stranded noncoding RNA and their role in chronic obstructive pulmonary disease Yan Yanfeng, Qi Wenxia, Cui Yonghui, Wei Caihong Journal of Tuberculosis and Lung Disease    2024, 5 (2): 172-178.   DOI: 10.19983/j.issn.2096-8493.20240040 Abstract （111）   HTML （7）    PDF（pc） （800KB）（18）       Knowledge map    Save Chronic obstructive pulmonary disease (COPD) is a kind of preventable and treatable chronic lung disease characterized by persistent respiratory symptoms and airflow limitation. Long non-coding RNA (lncRNA) is a class of transcription products with long nucleotide chains that exert a variety of biological effects by regulating the expression of related molecules in various forms. In recent years, it has been demonstrated that lncRNA can be involved in the pathological response of COPD by regulating various molecular biological processes such as inflammatory response, oxidative stress and apoptosis, and have gradually become an important target for the diagnosis and treatment of COPD. In this paper, we reviewed the research progress of lncRNA expression in COPD, oxidative stress, human pulmonary microvascular endothelial cells apoptosis, and their role in pathological mechanisms, with the aim of providing new ideas and directions for the diagnosis and efficacy assessment of COPD. Reference | Related Articles | Metrics

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Research progress on the correlation between pyroptosis and metastasis of non-small cell lung cancer Chang Yuting, Zhang Xinran, Han Gaohua Journal of Tuberculosis and Lung Disease    2024, 5 (3): 260-266.   DOI: 10.19983/j.issn.2096-8493.2024082 Abstract （111）   HTML （4）    PDF（pc） （722KB）（13）       Knowledge map    Save With the increasing incidence and mortality of non-small cell lung cancer (NSCLC), the focus and challenge of researches have been shifted towards delaying disease progression and prolonging patient survival. Metastasis is an inevitable aspect of tumor development which significantly affects patients’ median length of survival. Therefore, predicting metastasis occurrence and conducting preventive treatment are crucial for improving NSCLC prognosis. Some researchers have raised concerns about pyroptosis as a programmed cell death mode that can be expressed in both normal tissue and tumor cells, with distinctive biological effects in different types of tumor. This paper provides a summary of different activation pathways and application values of pyroptosis, focusing on its dual role in NSCLC metastasis. It suggests that pyroptosis may play an important role in targeted metastasis when considering current researches on brain metastasis of non-small cell lung cancer, offering a new approach to study the correlation between cell pyroptosis and NSCLC metastasis. Reference | Related Articles | Metrics

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Clinical value of IFIT3 and PCT in prognosis evaluation of elderly patients with severe tuberculosis Wei Yunxia, Wang Xin, Long Xuejuan, Shao Lijiao, Yan Lijing, Yu Di, Li Ning Journal of Tuberculosis and Lung Disease    2024, 5 (2): 143-147.   DOI: 10.19983/j.issn.2096-8493.2024030 Abstract （109）   HTML （6）    PDF（pc） （901KB）（19）       Knowledge map    Save Objective: To investigate the value of IFIT3 (interferon-induced protein with tetratricopeptide repeats 3,IFIT3) and procalcitonin (PCT) in the prognosis of elderly patients with severe pulmonary tuberculosis (PTB). Methods: In this prospective study, 82 elderly patients with severe PTB in the ICU of Hebei Chest Hospital from April 2022 to March 2023 were selected as study objects, and divided into survival group (42 cases) and death group (40 cases) according to the outcomes of the patients after they admitted to the ICU for 28 days. Clinical data of these two groups of patients were collected, and serum IFIT3 and PCT contents were determined by enzyme-linked immunosorbent assay (ELISA). The predictive value of IFIT3 and PCT on death was then analyzed by plotting receiver operating characteristic (ROC) curve, while the prognosis at 28 days after admission to ICU was used as the reference standard. Results: The acute physiology and chronic health status assessment system Ⅱ (APACHEⅡ) score, serum IFIT3 and PCT level of the elderly patients with severe PTB in the death group were 25.68±8.12, 21.00 (13.00, 48.00) pg/ml and 3.21 (0.96, 5.78) ng/ml, respectively, higher than those in the survival group (21.17±8.57, 11.00 (5.75, 22.75) pg/ml and 0.41 (0.15, 1.04) ng/ml). The differences were statistically significant (t=-2.373, P=0.018;Z=-2.920, P=0.003;Z=2.028, P=0.001). The area under ROC curve (AUC) of IFIT3 and PCT were 0.687 (95%CI:0.572-0.803) and 0.832 (95%CI:0.741-0.922) respectively for predicting death. When the optimal threshold value of IFIT3 was 12.50 pg/ml, the sensitivity and specificity of predicting death were 77.5% and 59.5%. When the optimal threshold of serum PCT was 1.44 ng/ml, the sensitivity and specificity of predicting death were 72.5% and 83.3%. AUC of combing IFIT3 with PCT in predicting death was 0.850 (95%CI: 0.767-0.933), the sensitivity and specificity were 75.0% and 83.3%, and the positive predictive value and negative predictive value were 81.1% and 75.6%. Conclusion: IFIT3 combined with PCT test has a certain clinical value in the prognosis assessment of elderly patients with severe PTB in ICU. Table and Figures | Reference | Related Articles | Metrics

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Epidemiological characteristics of pulmonary tuberculosis from Meigu County,Liangshan Yi Autonomous Prefecture from 2019 to 2023 Lezhe Laji, He Xin, Xu Qiang, Fan Li, Cao Hongju, Sun Shanhua Journal of Tuberculosis and Lung Disease    2024, 5 (4): 311-316.   DOI: 10.19983/j.issn.2096-8493.2024096 Abstract （107）   HTML （7）    PDF（pc） （1342KB）（59）       Knowledge map    Save Objective: To analyze the epidemiological characteristics of pulmonary tuberculosis from Meigu County, Liangshan Prefecture from 2019 to 2023, and to provide basis for tuberculosis prevention and control. Methods: The reported incidence data of pulmonary tuberculosis from Meigu County was collected from the China Tuberculosis Information Management System, and the population data was obtained from survey date during screeing of Meigu County. And then we analyzed the data using the descriptive epidemiological methods. Results: A total of 4598 cases of pulmonary tuberculosis were reported in Meigu County from 2019 to 2023, the average annual reported incidence rate during this period was 375.23/100000, showing an increasing trend in annual incidence rates (Cochran-Armitage test,Z=14.90,P<0.01). 51.89% (2386/4598) of the reported cases were reported from outside the county. Pulmonary tuberculosis cases were reported in all 18 townships in Meigu County, with the top five townships having the highest reported incidence rates being Lama Township (634.57/100000), Luoeyigan Township (448.24/100000), Liuhong Township (442.05/100000), Hougumo Township (431.14/100000), and Dianbu Township (431.09/100000). The lowest reported incidence rate was observed in Hongxi Township (213.20/100000). Among all reported cases,the incidence rate of pulmonary tuberculosis among males (432.72/100000) was higher than that among females (156.28/100000), the difference is statistically significant (χ2=121.32,P<0.01),with a male-to-female ratio of 1.40∶1(2683/1915). 78.77% (3622/4598) of reported cases occurred in the age group of 15-65 years. The incidence rate of adolescents aged 10-19 years is as high as 400.25/100000, of which the incidence rate of children under 15 years old is as high as 154.99/100000.The main occupations of the patients were farmers (67.14%,3087/4598) followed by students/teachers (24.34%,1119/4598). Conclusion: The epidemic situation of pulmonary tuberculosis in Meigu County is very serious. Comprehensive prevention and control measures should be taken according to local conditions, health education for tuberculosis prevention and control should be paid attention to, the level of patient detection should be improved, and the management of patient treatment should be strengthened in order to achieve a TB free community and a TB free county. Table and Figures | Reference | Related Articles | Metrics

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Evaluation the application of information-based hybrid teaching model in thoracic imaging diagnosis education Wu Ning, Tang Ke, Sun Weirong Journal of Tuberculosis and Lung Disease    2024, 5 (2): 168-171.   DOI: 10.19983/j.issn.2096-8493.20230129 Abstract （105）   HTML （4）    PDF（pc） （939KB）（19）       Knowledge map    Save Objective: To explore the teaching effect of clinical medical undergraduates in chest imaging diagnosis with the information-based mixed teaching mode. Methods: A total of 62 medical imaging undergraduates undergoing rotation training in the Department of Radiology of the Eighth Medical Center of PLA General Hospital from September 2018 to September 2022 were selected and divided into the Observation Group (with information-based mixed teaching model) and the control group (with traditional teaching model). The improvement of self-regulated learning ability of the two groups was evaluated by questionnaires, and the innovation ability was evaluated using scientific research design and simulated report, the problem-solving ability was assessed through film review and case analysis. A total of 62 questionnaires were distributed and 62 valid questionnaires were recovered. Results: The self-regulated learning ability scores of the two groups were (4.52±0.57) and (3.35±0.75), respectively, the difference was statistically significant (t=6.836, P<0.001); the scores of innovation ability were (3.94±0.73) and (2.84±1.01), respectively, with significant difference (t=4.928, P<0.001); and the scores of problem solving ability were (76.90±3.71) and (68.81±4.57), respectively, the difference was also statistically significant (t=7.651, P<0.001). Conclusion: The information-based hybrid teaching mode can improve the ability of self-directed learning, innovation, and problem-solving in the diagnosis of chest imaging for clinical medical undergraduate students. Table and Figures | Reference | Related Articles | Metrics