Research progress on the concept discrimination and treatment of type 2 inflammation in asthma

doi:10.19983/j.issn.2096-8493.2024107

Abstract

Abstract:

Bronchial asthma (asthma) is a heterogeneous disease with multiple phenotypes based on differences in clinical features, triggers, airway inflammation, physiological and pathological features. The Global Initiative for Asthma (GINA) guidelines suggest that type 2 inflammation exists in asthma and can be diagnosed by testing for eosinophils, exhaled nitric oxide, and allergens. It has been found that 50% to 70% of asthma patients are related to type 2 inflammation, and the proportion of type 2 inflammation in severe asthma patients in China is more than 75%. Therefore, drug development and treatment for type 2 inflammation are critical. The authors review the concept, classification, pathogenesis, biomarkers and judgment criteria, asthma and the research progress of targeted therapy of type 2 inflammatory, and provides reference for the diagnostic and treatment of asthma biologics.

Key words: Inflammation mediators, Bronchial hyperreactivity, Asthma, Biological markers

CLC Number:

Shi Xu, Chen Ruchong, Li Jing. Research progress on the concept discrimination and treatment of type 2 inflammation in asthma[J]. Journal of Tuberculosis and Lung Disease , 2024, 5(5): 489-494. doi: 10.19983/j.issn.2096-8493.2024107

Figures/Tables 4

References 41

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通用名	靶点	适用人群	生物标志物指导临床应用	推荐
奥马珠单抗 (omalizumab)	IgE	6岁及以上儿童和成人的中、重度过敏性患者	基线血清总IgE水平在30~1300IU/ml(6~12岁)和30~700IU/ml(12岁以上),可以选择抗IgE抗体	中国:√ GINA:√
瑞替珠单抗 (reslizumab)	IL-5	18岁及以上成人重度EOS型患者	血EOS≥150个/μl或300个/μl可作为使用抗IL-5或IL-5R抗体的指征	中国:√ GINA:√
美泊利珠单抗 (mepolizumab)	IL-5	6岁及以上儿童和成人重度EOS型患者		中国:√ GINA:√
本瑞利珠单抗 (benralizumab)	IL-5R	12岁及以上青少年和成人重度EOS型患者		中国:√ GINA:√
度普利尤单抗 (dupilumab)	IL-4R	6岁及以上儿童和成人重度EOS型/2型患者或OCS依赖型患者	基线血清总IgE水平≥150个/μl且≤1500个/μl,或FeNO≥25ppb	中国:√ GINA:√
特泽鲁单抗 (tezepelumab)	TSLP	12岁及以上青少年和成人重度患者	血EOS或FeNO升高	中国:× GINA:√