Research progress on the regulation of TLR4 signaling pathway by miR-451a in the pathogenesis of tuberculosis

doi:10.19983/j.issn.2096-8493.2024097

Abstract

Abstract:

MicroRNAs (miRNAs) play a pivotal role in immune regulation and inflammatory responses, contributing to the onset and progression of various diseases. miR-451a, a specific microRNA, is predominantly expressed in erythroid precursors and has been implicated in the pathogenesis of hematological disorders such as leukemia, as well as in non-hematological diseases including congenital heart disease, esophageal cancer, multiple myeloma, and sepsis. Furthermore, miR-451a modulates the TLR4 signaling pathway, thereby influencing the pathogenesis of tuberculosis. The authors investigated the mechanism by which miR-451a regulates the TLR4 signaling pathway, with the goal of examining recent advancements in understanding the role of miR-451a in tuberculosis pathogenesis. This study aims to provide novel theoretical insights for the identification of potential targets in anti-tuberculosis drug development.

Key words: MicroRNAs, Signal transduction, Tuberculosis, Review literature as topic

CLC Number:

Zhao Fei, Zhan Lu. Research progress on the regulation of TLR4 signaling pathway by miR-451a in the pathogenesis of tuberculosis[J]. Journal of Tuberculosis and Lung Disease , 2024, 5(5): 484-488. doi: 10.19983/j.issn.2096-8493.2024097

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