Single nucleotide polymorphisms and related genes in Chinese children with type 2 inflammatory asthma

doi:10.19983/j.issn.2096-8493.2024086

Abstract

Abstract:

Bronchial asthma is a chronic inflammatory disease that significantly impacts the physical and mental health of children. It is classified into type 2 inflammatory asthma and non-type 2 inflammatory asthma based on distinct mechanisms and manifestations of inflammation. Type 2 inflammatory asthma represents a substantial proportion of pediatric asthma cases, characterized by severe symptoms and poor clinical outcomes. The pathogenesis of asthma is complex, with genetic variation playing a critical role in its onset and progression. Developing diagnostic models and individualized treatment plans from a genetic perspective is therefore of paramount importance. The authors systematically summarizes current research on gene regions and single nucleotide polymorphisms associated with type 2 asthma, aiming to elucidate the relationship between genetic factors and the development of asthma, and to provide a foundation for future predictive diagnostic models and individualized treatment strategies for asthma.

Key words: Asthma, Polymorphism, single nucleotide polymorphism, Child, Genes

CLC Number:

R256.12

Su XingYue, Wang Beilei, Ma Xiang. Single nucleotide polymorphisms and related genes in Chinese children with type 2 inflammatory asthma[J]. Journal of Tuberculosis and Lung Disease , 2024, 5(4): 370-375. doi: 10.19983/j.issn.2096-8493.2024086

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