Progress in tuberculosis infection screening, diagnosis and treatment of female infertility patients before in vitro fertilization-embryo transfer

doi:10.19983/j.issn.2096-8493.2024053

Abstract

Abstract:

In vitro fertilization-embryo transfer (IVF-ET) is an effective method for treating female infertility. During IVE-ET course, patients with female reproductive system tuberculosis have certain risk of activating tuberculosis to recurrent, which leads to low success rate of IVF-ET and high incidence of adverse events. In China, large number of patients have active tuberculosis disease or tuberculosis latent infection. Screening for tuberculosis infection before IVF-ET in infertile women and then taking necessary intervention can improve the success rate of IVF-ET and reduce the incidence of adverse events. At present, there is no conclusion on standard treatment before IVE-ET for infertile women with female reproductive system tuberculosis infection. This article reviews the application of laboratory, imaging, endoscopic, and pathological examination and anti-tuberculosis treatment in screening, diagnosis and treatment of female reproductive system tuberculosis infection, in order to provide clinical reference for the screening and treatment of tuberculosis infection in infertile women before IVF-ET.

Key words: Tuberculosis, Fertilization in vitro, Embryo transfer, Diagnosis, Therapeutics

CLC Number:

R715.2
R52

Li Yabo, Fan Lijuan, Sun Xiuli, Gou Liangzhi, Ren Beiying, Shi Juanzi, Wang Fang, Ma Xiaoling, Xie Yonghong, Liu Xin, Wu Qianhong. Progress in tuberculosis infection screening, diagnosis and treatment of female infertility patients before in vitro fertilization-embryo transfer[J]. Journal of Tuberculosis and Lung Disease , 2024, 5(4): 352-357. doi: 10.19983/j.issn.2096-8493.2024053

References 46

[1]	Sterling TR, Njie G, Zenner D, et al. Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020. MMWR Recomm Rep, 2020, 69(1): 1-11. doi:10.15585/mmwr.rr6901a1.
[2]	Sharma JB, Sharma E, Sharma S, et al. Female genital tuberculosis: Revisited. Indian J Med Res, 2018, 148(Suppl): S71-S83. doi:10.4103/ijmr.IJMR_648_18.
[3]	Gai XY, Chi HB, Zeng L, et al. Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study. Biomed Environ Sci, 2021, 34(2): 130-138. doi:10.3967/bes2021.019.
[4]	Jirge PR, Chougule SM, Keni A, et al. Latent genital tuberculosis adversely affects the ovarian reserve in infertile women. Hum Reprod, 2018, 33(7): 1262-1269. doi:10.1093/humrep/dey117.
[5]	Wang Y, Shao R, He C, et al. Emerging progress on diagnosis and treatment of female genital tuberculosis. J Int Med Res, 2021, 49(5): 3000605211014999. doi:10.1177/0300060521 1014999.
[6]	唐春艳, 邓姗. 隐匿性结核对于辅助生育的潜在风险. 生殖医学杂志, 2021, 30(9):1232-1234. doi:10.3969/j.issn.1004-3845.2021.09.018.
[7]	Wang K, Ren D, Qiu Z, et al. Clinical analysis of pregnancy complicated with miliary tuberculosis. Ann Med, 2022, 54(1): 71-79. doi:10.1080/07853890.2021.2018485. pmid: 34955089
[8]	Ye R, Wang C, Zhao L, et al. Characteristics of miliary tuberculosis in pregnant women after in vitro fertilisation and embryo transfer. Int J Tuberc Lung Dis, 2019, 23(2): 136-139. doi:10.5588/ijtld.18.0223. pmid: 30621812
[9]	Bhanothu V, Theophilus JP, Reddy PK, et al. Occurrence of female genital tuberculosis among infertile women: a study from a tertiary maternal health care research centre in South India. Eur J Clin Microbiol Infect Dis, 2014, 33(11): 1937-1949. doi:10.1007/s10096-014-2164-1.
[10]	中华医学会结核病学分会儿童结核病专业委员会, 国家儿童医学中心, 首都医科大学附属北京儿童医院, 等. 儿童结核分枝杆菌潜伏感染筛查和预防性治疗专家共识. 中华结核和呼吸杂志, 2020, 43(4): 345-349. doi:10.3760/cma.j.cn112147-20200106-00006.
[11]	上海市防痨协会, 中国防痨协会青年理事会, 《中国防痨杂志》编辑委员会. 学校结核病疫情流行病学调查和现场处置专家共识. 中国防痨杂志, 2019, 41 (1): 9-13. doi:10.3969/j.issn.1000-6621.2019.01.004.
[12]	姚嵩, 方雪晖. 《中国结核病预防控制工作技术规范(2020年版)》解读与思考. 热带病与寄生虫学, 2020, 18(3): 138-141. doi:10.3969/j.issn.1672-2302.2020.03.002.
[13]	何翼君, 曹雪芳, 高磊. 《结核菌素皮肤试验-γ干扰素释放试验两步法的操作技术规范》解读. 中国防痨杂志, 2022, 44(5):438-441. doi:10.19982/j.issn.1000-6621.20210731.
[14]	中华医学会结核病学分会. 结核分枝杆菌γ-干扰素释放试验及临床应用专家意见(2021年版). 中华结核和呼吸杂志, 2022, 45(2): 143-150. doi:10.3760/cma.j.cn112147-20211110-00794.
[15]	高磊, 权竹声, 成君, 等. 结核分枝杆菌感染检测两步法在学校结核病控制工作中的应用探讨. 中华预防医学杂志, 2020, 54(4): 385-391. doi:10.3760/cma.j.cn112150-20191204-00909.
[16]	中国防痨协会, 中国防痨协会学校与儿童结核病防治专业分会, 《中国防痨杂志》编辑委员会. 重组结核杆菌融合蛋白(EC)临床应用专家共识. 中国防痨杂志, 2020, 42(8): 761-768. doi:10.3969/j.issn.1000-6621.2020.08.001.
[17]	程晓, 陈哲, 焦雪峰, 等. 重组结核杆菌融合蛋白(EC)用于诊断结核分枝杆菌感染的有效性和安全性系统评价. 中国防痨杂志, 2022, 44(9): 917-926. doi:10.19982/j.issn.1000-6621.20220253.
[18]	韩伟, 崔俊伟, 黄健, 等. 三种结核抗体联合检测对活动性肺结核的诊断价值. 分子诊断与治疗杂志, 2022, 14(1): 10-13, 18. doi:10.3969/j.issn.1674-6929.2022.01.004.
[19]	董晓伟, 刘玉琴, 卢水华. 结核分枝杆菌潜伏感染的治疗:利大于弊还是弊大于利. 中国实用内科杂志, 2019, 39(5): 443-446. doi:10.19538/j.nk2019050112.
[20]	吕平欣, 贺伟, 吕岩, 等. 基于影像学特征把握非活动性肺结核的影像学诊断要点. 中国防痨杂志, 2022, 44(4):305-309. doi:10.19982/j.issn.1000-6621.20220002.
[21]	国家感染性疾病临床医学研究中心, 深圳市第三人民医院,《中国防痨杂志》编辑委员会. 肺结核活动性判断规范及临床应用专家共识. 中国防痨杂志, 2020, 42(4): 301-307. doi:10.3969/j.issn.1000-6621.2020.04.001.
[22]	中华医学会放射学分会传染病放射学专业委员会. 肺结核影像学及分级诊断专家共识. 新发传染病电子杂志, 2018, 3(2): 118-127. doi:10.3877/j.issn.2096-2738.2018.02.017.
[23]	陈超, 王金娟, 袁静. 女性生殖器结核的临床表现及腹腔镜与宫腔镜检查特点分析. 中华妇幼临床医学杂志(电子版), 2018, 14(1): 62-67. doi:10.3877/cma.j.issn.1673-5250.2018.01.010.
[24]	孙秀利, 李亚波, 缑良芝, 等. 宫腹腔镜检查在不孕女性疑似生殖器结核的应用价值. 结核与肺部疾病杂志, 2022, 3(5):377-381. doi:10.19983/j.issn.2096-8493.20220134.
[25]	曹云云, 牛建梅, 姚世发, 等. 分析女性生殖器结核的临床特点及超声诊断. 中国超声医学杂志, 2017, 33(8):721-723. doi:10.3969/j.issn.1002-0101.2017.08.015.
[26]	袁怡清, 曹蕾, 曹力, 等. 经阴道实时三维超声子宫输卵管超声造影和X线子宫输卵管碘油造影在女性不孕症中的临床应用价值. 中国妇幼保健, 2021, 36(21): 4997-4999. doi:10.19829/j.zgfybj.issn.1001-4411.2021.21.035.
[27]	输卵管通畅性检查专家共识编写组. 输卵管通畅性检查专家共识. 中华生殖与避孕杂志, 2021, 41(8): 669-674. doi:10.3760/cma.j.cn101441-20201112-00618.
[28]	刘琳琳, 黄晓武, 夏恩兰. 子宫内膜结核的宫腔镜检查和组织病理学诊断分析. 国际妇产科学杂志, 2018, 45(2): 203-206. doi:10.3969/j.issn.1674-1870.2018.02.021.
[29]	李寅, 胡红文, 杨丽菁, 等. 腹腔镜联合宫腔镜检查对结核性不孕的诊治价值. 中国临床医学, 2011, 18(2): 205-206. doi:10.3969/j.issn.1008-6358.2011.02.025.
[30]	乌云塔娜, 刘玲玲, 赵勇, 等. 宫腹腔镜联合诊治女性不孕症461例临床疗效分析. 中国计划生育学杂志, 2016, 24(4): 256-260. doi:10.3969/j.issn.1004-8189.2016.04.
[31]	温宝宁, 陈兰芳, 车小群, 等. 子宫内膜结核在宫腔镜下的图像特征. 中国热带医学, 2009, 9(8): 1530-1531.
[32]	杨松, 王乐乐, 韩梅, 等. 世界卫生组织耐药结核病治疗整合指南(2020年版)解读. 国际呼吸杂志, 2021, 41(6): 401-409. doi:10.3760/cma.j.cn131368-20200628-00553.
[33]	李果, 庞先琼, 徐华, 等. 潜伏性结核感染诊治进展. 中国防痨杂志, 2021, 43(1): 91-95. doi:10.3969/j.issn.1000-6621.2021.01.017.
[34]	马晓玲, 袁月, 李宏睿, 等. 23例体外受精-胚胎移植术后妊娠并发结核临床分析. 现代妇产科进展, 2022, 31(10): 763-766. doi:10.13283/j.cnki.xdfckjz.2022.10.007.
[35]	李琦, 卜志勤, 杨子尧, 等. 非活动性结核对不孕患者IVF/ICSI-ET助孕结局的影响. 中华生殖与避孕杂志, 2023, 43(8):784-791. doi:10.3760/cma.j.cn101441-20230106-00014.
[36]	Gupta S, Gupta P. Etiopathogenesis, Challenges and Remedies Associated With Female Genital Tuberculosis: Potential Role of Nuclear Receptors. Front Immunol, 2020, 11: 02161. doi:10.3389/fimmu.2020.02161. pmid: 33178178
[37]	中国防痨协会. 非活动性肺结核诊断及预防发病专家共识. 结核与肺部疾病杂志, 2021, 2(3):197-201. doi:10.3969/j.issn.2096-8493.20210085.
[38]	杜莹, 张彬, 王大宽, 等. 非活动性肺结核人群的流行病学特征和预防干预. 中国防痨杂志, 2020, 42(11):1232-1236. doi:10.3969/j.issn.1000-6621.2020.11.016.
[39]	Gai X, Chi H, Zeng L, et al. Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study. Front Med (Lausanne), 2021, 8: 749410. doi:10.3389/fmed.2021.749410.
[40]	中华人民共和国国家卫生和计划生育委员会. WS 196—2017 结核病分类. 2017-11-09.
[41]	中华人民共和国国家卫生和计划生育委员会. WS 288—2017 肺结核诊断. 2017-11-09.
[42]	中华医学会, 中华医学会临床药学分会, 中华医学会杂志社, 等. 肺结核基层合理用药指南. 中华全科医师杂志, 2020, 19(10): 891-899. doi:10.3760/cma.j.cn114798-20200520-00601.
[43]	中华医学会结核病学分会. 中国耐多药和利福平耐药结核病治疗专家共识(2019年版). 中华结核和呼吸杂志, 2019, 42(10): 733-749. doi:10.3760/cma.j.issn.1001-0939.2019.10.006.
[44]	彭城, 项莉. 武汉市初治涂阳肺结核患者规范化隔离治疗住院费用及治疗效果分析. 医学与社会, 2020, 33(6): 69-72. doi:10.13723/j.yxysh.2020.06.017.
[45]	赖培烜, 秦道新, 田园, 等. 互联网技术+手机微信小程序的患者管理模式探讨. 中国热带医学, 2020, 20(4): 394-396. doi:10.13604/j.cnki.46-1064/r.2020.04.22.
[46]	Alsayed SSR, Gunosewoyo H. Tuberculosis: Pathogenesis, Current Treatment Regimens and New Drug Targets. Int J Mol Sci, 2023, 24(6): 5202. doi:10.3390/ijms24065202.